Showing entry for Glycine--tRNA ligase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010244
Protein NameGlycine--tRNA ligase
Uniport IdP41250
GeneGARS1
Gene Id2617
DomainHGTP_anticodon; tRNA-synt_2b; WHEP-TRS
Pfam PF03129   PF00587   PF00458  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015966 diadenosine tetraphosphate biosynthetic process
Biological Process GO:0006426 glycyl-tRNA aminoacylation
Biological Process GO:0070150 mitochondrial glycyl-tRNA aminoacylation
Biological Process GO:0006418 tRNA aminoacylation for protein translation
molecular function GO:0005524 ATP binding
molecular function GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
molecular function GO:0004820 glycine-tRNA ligase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0046983 protein dimerization activity
molecular function GO:0016740 transferase activity
cellular component GO:0030424 axon
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0030141 secretory granule
Reactome
Pathway Id Pathway Name
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379724 tRNA Aminoacylation
R-HSA-379726 Mitochondrial tRNA aminoacylation
R-HSA-392499 Metabolism of proteins
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006666 BXGD000405 Calciphylaxis Nutritional and Metabolic Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011633 BXGD000742 Dermatomyositis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027888 BXGD002056 Hereditary Motor and Sensory Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0175693 BXGD004001 Russell-Silver syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0205713 BXGD004114 Roussy-Levy Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0221032 BXGD004374 Familial generalized lipodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0221056 BXGD004383 Adult type dermatomyositis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234166 BXGD004628 Hyperexplexia Nervous System Diseases
C0235025 BXGD004713 Peripheral motor neuropathy Nervous System Diseases
C0270914 BXGD006131 Hereditary Motor and Sensory-Neuropathy Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270921 BXGD006133 Axonal neuropathy Nervous System Diseases
C0271683 BXGD006234 Polyneuropathy, Motor Nervous System Diseases
C0376154 BXGD007980 Skin callus Skin and Connective Tissue Diseases
C0393541 BXGD008084 Distal Spinal Muscular Atrophy Nervous System Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751409 BXGD010431 Upper Extremity Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C1136179 BXGD011712 Hammer Toe Musculoskeletal Diseases
C1295585 BXGD012241 Decreased vibratory sense Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1408174 BXGD013034 Hypertrophic neuropathy of infancy
C1408182 BXGD013035 Hereditary motor and sensory neuropathy, types I-IV
C1578482 BXGD013427 Valgus deformities of feet Musculoskeletal Diseases
C1698196 BXGD013513 Muscle Weakness Upper Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1832274 BXGD013820 Charcot-Marie-Tooth disease, Type 2D Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1832276 BXGD013821 Thenar muscle weakness
C1832277 BXGD013822 First dorsal interossei muscle weakness
C1832278 BXGD013823 First dorsal interossei muscle atrophy
C1832279 BXGD013824 Cold-induced hand cramps
C1833308 BXGD013910 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE V Nervous System Diseases
C1836450 BXGD014117 Distal lower limb muscle weakness
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848736 BXGD014970 Distal amyotrophy
C1854494 BXGD015409 Slow progression
C1864715 BXGD016244 Thenar muscle atrophy
C1865384 BXGD016324 Amyotrophy, monomelic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2875300 BXGD017836 Peroneal muscular atrophy (axonal type) (hypertrophic type)
C2931276 BXGD017994 Spastic paraplegia 17 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3468114 BXGD018906 Juvenile amyotrophic lateral sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021031 BXGD020527 Abnormal motor nerve conduction velocity
C4021523 BXGD020650 Upper limb amyotrophy
C4024896 BXGD021461 Motor neuron atrophy
C4274109 BXGD022346 Autosomal dominant Charcot-Marie-Tooth disease type 2D Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0024261 Adenosine Phosphate 347.06
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein