Showing entry for Protein kinase C iota type


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010270
Protein NameProtein kinase C iota type
Uniport IdP41743
GenePRKCI
Gene Id5584
DomainC1_1; PB1; Pkinase; Pkinase_C
Pfam PF00130   PF00564   PF00069   PF00433  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007015 actin filament organization
Biological Process GO:0070830 bicellular tight junction assembly
Biological Process GO:0045216 cell-cell junction organization
Biological Process GO:0016477 cell migration
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0035089 establishment of apical/basal cell polarity
Biological Process GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Biological Process GO:0042462 eye photoreceptor cell development
Biological Process GO:0048194 Golgi vesicle budding
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0061024 membrane organization
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0034351 negative regulation of glial cell apoptotic process
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:2000353 positive regulation of endothelial cell apoptotic process
Biological Process GO:0060252 positive regulation of glial cell proliferation
Biological Process GO:0046326 positive regulation of glucose import
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0045747 positive regulation of Notch signaling pathway
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
Biological Process GO:0070555 response to interleukin-1
Biological Process GO:0046903 secretion
Biological Process GO:0016192 vesicle-mediated transport
molecular function GO:0005524 ATP binding
molecular function GO:0004698 calcium-dependent protein kinase C activity
molecular function GO:0046872 metal ion binding
molecular function GO:0005543 phospholipid binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004697 protein kinase C activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005923 bicellular tight junction
cellular component GO:0031252 cell leading edge
cellular component GO:0005829 cytosol
cellular component GO:0005768 endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0000139 Golgi membrane
cellular component GO:0045171 intercellular bridge
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0098685 Schaffer collateral - CA1 synapse
cellular component GO:0043220 Schmidt-Lanterman incisure
Reactome
Pathway Id Pathway Name
R-HSA-1500931 Cell-Cell communication
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-193639 p75NTR signals via NF-kB
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-209543 p75NTR recruits signalling complexes
R-HSA-420029 Tight junction interactions
R-HSA-421270 Cell-cell junction organization
R-HSA-446728 Cell junction organization
R-HSA-73887 Death Receptor Signalling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0010709 BXGD000689 Cyst Pathological Conditions, Signs and Symptoms; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018923 BXGD001248 Hemangiosarcoma Neoplasms
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0040188 BXGD002850 Tic disorder Nervous System Diseases; Mental Disorders
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0206655 BXGD004218 Alveolar rhabdomyosarcoma Neoplasms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0259785 BXGD005222 Malignant Meningioma Neoplasms; Nervous System Diseases
C0278076 BXGD006493 Behavioral tic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278592 BXGD006544 Adult Angiosarcoma Neoplasms
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0279613 BXGD006651 Childhood Alveolar Rhabdomyosarcoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279988 BXGD006707 Childhood Angiosarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0750927 BXGD010254 Apraxia, Developmental Verbal Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1335177 BXGD012771 Ovarian Serous Adenocarcinoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519680 BXGD013244 Tumor Immunity Pathological Conditions, Signs and Symptoms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1840264 BXGD014439 IMMUNE SUPPRESSION
C2169806 BXGD016935 recurrent muscle twitches (symptom) Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2930930 BXGD017919 Abdominal obesity metabolic syndrome Nutritional and Metabolic Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4287589 BXGD022469 Serous Tubal Intraepithelial Carcinoma
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722419 BXGD023802 Extrapulmonary Small Cell Carcinoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000063 Galloyl glucose 332.26
BXGC0000436 Glycerol 92.09
BXGC0001545 Harmine 212.25
BXGC0002029 Taxifolin 304.25
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0003403 Phasin 523.73
BXGC0003705 Chloride 35.45
BXGC0003772 Corilagin 634.45
BXGC0003789 1,6-di-O-Galloylglucose 484.37
BXGC0004115 Norharman 168.19
BXGC0006368 Formic acid 46.03
BXGC0008707 Isoliquiritigenin 256.25
BXGC0009230 Proanthocyanidin B2 3,3'-digallate 882.73
BXGC0009557 Procyanidin C1 866.78
BXGC0012352 Chelerythrine 348.12
BXGC0012913 Pentagalloyl Glucose 940.12
BXGC0013881 Cucurbitacin I 514.29
BXGC0014303 n.a 344.07
BXGC0014883 Clausine E 241.07
BXGC0015010 Chebulagic Acid 954.1
BXGC0018192 vescalagin 934.07
BXGC0019625 Prostratin 390.2
BXGC0029271 Cucurbitacin E 556.3
BXGC0031878 3-O-Galloylshikimic Acid 326.06
BXGC0033667 n.a 648.1
BXGC0034873 n.a 802.09
BXGC0042191 vescalagin 934.07
BXGC0042352 procyanidin A2 576.13
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0043221 1-O,4-O,6-O-Trigalloyl-alpha-D-glucopyranose 636.1
BXGC0043892 E181 1120.09
BXGC0044194 Punicafolin 938.1
BXGC0044244 1,2,6-Tri-O-Galloyl-Beta-D-Glucose 636.1
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0048159 Phorbol Myristate Acetate 616.4
BXGC0048578 Rediocide A 794.39
BXGC0049447 acetate 59.01
BXGC0050483 Hamamelitannin 484.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein