Showing entry for Signal transducer and activator of transcription 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010287
Protein NameSignal transducer and activator of transcription 1
Uniport IdP42225
GeneStat1
Gene Id
DomainSH2; STAT1_TAZ2bind; STAT_alpha; STAT_bind; STAT_int
Pfam PF00017   PF12162   PF01017   PF02864   PF02865  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0008015 blood circulation
Biological Process GO:0071345 cellular response to cytokine stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0035458 cellular response to interferon-beta
Biological Process GO:0071346 cellular response to interferon-gamma
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0071407 cellular response to organic cyclic compound
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0006952 defense response
Biological Process GO:0051607 defense response to virus
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0031663 lipopolysaccharide-mediated signaling pathway
Biological Process GO:0010742 macrophage derived foam cell differentiation
Biological Process GO:0072162 metanephric mesenchymal cell differentiation
Biological Process GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
Biological Process GO:0046725 negative regulation by virus of viral protein levels in host cell
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0001937 negative regulation of endothelial cell proliferation
Biological Process GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0034240 negative regulation of macrophage fusion
Biological Process GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
Biological Process GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0002230 positive regulation of defense response to virus by host
Biological Process GO:0045648 positive regulation of erythrocyte differentiation
Biological Process GO:0032727 positive regulation of interferon-alpha production
Biological Process GO:0002053 positive regulation of mesenchymal cell proliferation
Biological Process GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0007259 receptor signaling pathway via JAK-STAT
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0061326 renal tubule development
Biological Process GO:0009617 response to bacterium
Biological Process GO:0051591 response to cAMP
Biological Process GO:0034097 response to cytokine
Biological Process GO:0042493 response to drug
Biological Process GO:0043330 response to exogenous dsRNA
Biological Process GO:0035456 response to interferon-beta
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0009612 response to mechanical stimulus
Biological Process GO:0007584 response to nutrient
Biological Process GO:0043434 response to peptide hormone
Biological Process GO:0034340 response to type I interferon
Biological Process GO:0006351 transcription, DNA-templated
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
Biological Process GO:0060337 type I interferon signaling pathway
molecular function GO:0031730 CCR5 chemokine receptor binding
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0019899 enzyme binding
molecular function GO:0035035 histone acetyltransferase binding
molecular function GO:0042393 histone binding
molecular function GO:0042802 identical protein binding
molecular function GO:0035257 nuclear hormone receptor binding
molecular function GO:1990841 promoter-specific chromatin binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0051721 protein phosphatase 2A binding
molecular function GO:0070491 repressing transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0005164 tumor necrosis factor receptor binding
molecular function GO:0044389 ubiquitin-like protein ligase binding
cellular component GO:0030424 axon
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0014107 Mammeasin A 484.25
BXGC0022863 n.a 420.18
BXGC0032279 Vernolide-B 434.19
BXGC0042416 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate 406.16
BXGC0042788 Hirsutinolide-13-Oacetate 338.14
BXGC0048131 Rel-8Alpha-Tigloyloxyhirsutinolide 378.17
BXGC0048874 8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate 420.18
BXGC0053183 Mesuol 392.16
BXGC0053388 Kayeassamin G 388.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein