Showing entry for Signal transducer and activator of transcription 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010289
Protein NameSignal transducer and activator of transcription 3
Uniport IdP42227
GeneStat3
Gene Id20848
DomainSH2; STAT_alpha; STAT_bind; STAT_int
Pfam PF00017   PF01017   PF02864   PF02865  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006953 acute-phase response
Biological Process GO:0007568 aging
Biological Process GO:0048708 astrocyte differentiation
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0071345 cellular response to cytokine stimulus
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0044320 cellular response to leptin stimulus
Biological Process GO:0071407 cellular response to organic cyclic compound
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0006952 defense response
Biological Process GO:0042755 eating behavior
Biological Process GO:0097009 energy homeostasis
Biological Process GO:0001754 eye photoreceptor cell differentiation
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0060396 growth hormone receptor signaling pathway
Biological Process GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
Biological Process GO:0006954 inflammatory response
Biological Process GO:0070102 interleukin-6-mediated signaling pathway
Biological Process GO:0030522 intracellular receptor signaling pathway
Biological Process GO:0033210 leptin-mediated signaling pathway
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0042789 mRNA transcription by RNA polymerase II
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045820 negative regulation of glycolytic process
Biological Process GO:0010730 negative regulation of hydrogen peroxide biosynthetic process
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:2001223 negative regulation of neuron migration
Biological Process GO:2000635 negative regulation of primary miRNA processing
Biological Process GO:2000737 negative regulation of stem cell differentiation
Biological Process GO:0016310 phosphorylation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:2001171 positive regulation of ATP biosynthetic process
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:1900017 positive regulation of cytokine production involved in inflammatory response
Biological Process GO:0045648 positive regulation of erythrocyte differentiation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:2000637 positive regulation of gene silencing by miRNA
Biological Process GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
Biological Process GO:0032733 positive regulation of interleukin-10 production
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:1904685 positive regulation of metalloendopeptidase activity
Biological Process GO:1905618 positive regulation of miRNA mediated inhibition of translation
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0045747 positive regulation of Notch signaling pathway
Biological Process GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
Biological Process GO:1904469 positive regulation of tumor necrosis factor secretion
Biological Process GO:1905564 positive regulation of vascular endothelial cell proliferation
Biological Process GO:0099527 postsynapse to nucleus signaling pathway
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0060019 radial glial cell differentiation
Biological Process GO:0007259 receptor signaling pathway via JAK-STAT
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0060259 regulation of feeding behavior
Biological Process GO:0046902 regulation of mitochondrial membrane permeability
Biological Process GO:0040014 regulation of multicellular organism growth
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0034097 response to cytokine
Biological Process GO:0042493 response to drug
Biological Process GO:0032355 response to estradiol
Biological Process GO:0045471 response to ethanol
Biological Process GO:0044321 response to leptin
Biological Process GO:0043434 response to peptide hormone
Biological Process GO:0019953 sexual reproduction
Biological Process GO:0019827 stem cell population maintenance
Biological Process GO:0001659 temperature homeostasis
Biological Process GO:0072540 T-helper 17 cell lineage commitment
Biological Process GO:0072538 T-helper 17 type immune response
Biological Process GO:0006366 transcription by RNA polymerase II
molecular function GO:0031730 CCR5 chemokine receptor binding
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0035259 glucocorticoid receptor binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004879 nuclear receptor activity
molecular function GO:0070878 primary miRNA binding
molecular function GO:0046983 protein dimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001103 RNA polymerase II repressing transcription factor binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0090575 RNA polymerase II transcription regulator complex
cellular component GO:0098685 Schaffer collateral - CA1 synapse
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001024 Cirsimaritin 314.29
BXGC0002588 Magnesium 24.31
BXGC0006368 Formic acid 46.03
BXGC0022863 n.a 420.18
BXGC0029880 8Alpha-Hydroxyhirsutinolide 296.13
BXGC0032279 Vernolide-B 434.19
BXGC0042416 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate 406.16
BXGC0042788 Hirsutinolide-13-Oacetate 338.14
BXGC0048131 Rel-8Alpha-Tigloyloxyhirsutinolide 378.17
BXGC0048874 8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate 420.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein