Showing entry for Exosome RNA helicase MTR4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010297
Protein NameExosome RNA helicase MTR4
Uniport IdP42285
GeneMTREX
Gene Id23517
DomainDEAD; DSHCT; Helicase_C; rRNA_proc-arch
Pfam PF00270   PF08148   PF00271   PF13234  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa03018 RNA degradation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000460 maturation of 5.8S rRNA
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0006401 RNA catabolic process
Biological Process GO:0006364 rRNA processing
Biological Process GO:0016076 snRNA catabolic process
molecular function GO:0005524 ATP binding
molecular function GO:0003723 RNA binding
molecular function GO:0003724 RNA helicase activity
cellular component GO:0071013 catalytic step 2 spliceosome
cellular component GO:0016607 nuclear speck
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0031499 TRAMP complex
Reactome
Pathway Id Pathway Name
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-72312 rRNA processing
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0007868 BXGD000498 Cervical dysplasia Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0343641 BXGD007636 Human papilloma virus infection Infections
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000696 Tartaric acid 150.09
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein