Showing entry for Tyrosine-protein kinase TXK



                       
General Target Information
BXGT IdBXGT010330
Protein NameTyrosine-protein kinase TXK
Uniport IdP42681
GeneTXK
Gene Id7294
DomainPkinase_Tyr; SH2; SH3_1
Pfam PF07714   PF00017   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007202 activation of phospholipase C activity
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0001816 cytokine production
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
Biological Process GO:0032729 positive regulation of interferon-gamma production
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0010543 regulation of platelet activation
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0042246 tissue regeneration
molecular function GO:0005524 ATP binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871809 FCERI mediated Ca+2 mobilization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C3828530 BXGD019744 Platelet Component Distribution Width Measurement
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012352 Chelerythrine 348.12
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein