Showing entry for Tyrosine-protein kinase ABL2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010331
Protein NameTyrosine-protein kinase ABL2
Uniport IdP42684
GeneABL2
Gene Id27
DomainF_actin_bind; Pkinase_Tyr; SH2; SH3_1
Pfam PF08919   PF07714   PF00017   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04012 ErbB signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
6. Human Diseases 6.6 Cardiovascular diseases hsa05416 Viral myocarditis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007155 cell adhesion
Biological Process GO:0006464 cellular protein modification process
Biological Process GO:0071300 cellular response to retinoic acid
Biological Process GO:0035640 exploration behavior
Biological Process GO:0035024 negative regulation of Rho protein signal transduction
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0051353 positive regulation of oxidoreductase activity
Biological Process GO:0010863 positive regulation of phospholipase C activity
Biological Process GO:2000249 regulation of actin cytoskeleton reorganization
Biological Process GO:0010506 regulation of autophagy
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:2000145 regulation of cell motility
Biological Process GO:0030100 regulation of endocytosis
Biological Process GO:0007165 signal transduction
molecular function GO:0051015 actin filament binding
molecular function GO:0003785 actin monomer binding
molecular function GO:0005524 ATP binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0030145 manganese ion binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0001784 phosphotyrosine residue binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004713 protein tyrosine kinase activity
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-376176 Signaling by ROBO receptors
R-HSA-376176 Signaling by ROBO receptors
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000744 BXGD000006 Abetalipoproteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024899 BXGD001812 Mastocytosis Neoplasms; Skin and Connective Tissue Diseases; Immune System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152020 BXGD003519 Gastroparesis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0162666 BXGD003967 Mitochondrial Encephalomyopathies Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0162671 BXGD003971 MELAS Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C0205710 BXGD004112 Alpers Syndrome (disorder) Immune System Diseases; Nervous System Diseases
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0238339 BXGD004914 Hereditary pancreatitis Digestive System Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0333983 BXGD006975 Hyperplastic Polyp Pathological Conditions, Signs and Symptoms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1720505 BXGD013676 Adult growth hormone deficiency
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1847540 BXGD014874 Azoospermia, Nonobstructive Male Urogenital Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0005624 Genistein 270.24
BXGC0012352 Chelerythrine 348.12
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0049391 Betadex 1134.37
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein