Showing entry for Sodium- and chloride-dependent GABA transporter 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010618
Protein NameSodium- and chloride-dependent GABA transporter 3
Uniport IdP48066
GeneSLC6A11
Gene Id6538
DomainSNF
Pfam PF00209  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.6 Nervous system hsa04721 Synaptic vesicle cycle
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007420 brain development
Biological Process GO:0015718 monocarboxylic acid transport
Biological Process GO:0001504 neurotransmitter uptake
Biological Process GO:0042493 response to drug
molecular function GO:0005332 gamma-aminobutyric acid:sodium symporter activity
molecular function GO:0008028 monocarboxylic acid transmembrane transporter activity
molecular function GO:0042165 neurotransmitter binding
cellular component GO:0005737 cytoplasm
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0016021 integral component of membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1430728 Metabolism
R-HSA-382551 Transport of small molecules
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-71288 Creatine metabolism
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-888590 GABA synthesis, release, reuptake and degradation
R-HSA-888593 Reuptake of GABA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0085648 BXGD003221 Synovial Cyst Neoplasms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0543891 BXGD009301 Neuroleptic-Induced Tardive Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C0686347 BXGD009832 Tardive Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1258666 BXGD011825 Myxoid cyst Neoplasms; Skin and Connective Tissue Diseases
C1272352 BXGD012013 Deficiency of vitamin D3 Nutritional and Metabolic Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1837454 BXGD014232 SPINOCEREBELLAR ATAXIA 8 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714760 BXGD019432 Drug-induced tardive dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001626 3-Aminopropanoic acid 89.09
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0026092 Hinokinin 354.11
BXGC0044598 Guvacine 127.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein