Showing entry for Glutathione synthetase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010649
Protein NameGlutathione synthetase
Uniport IdP48637
GeneGSS
Gene Id2937
DomainGSH_synthase; GSH_synth_ATP
Pfam PF03917   PF03199  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00270 Cysteine and methionine metabolism
1. Metabolism 1.6 Metabolism of other amino acids hsa00480 Glutathione metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.2 Cell growth and death hsa04216 Ferroptosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0006520 cellular amino acid metabolic process
Biological Process GO:0006750 glutathione biosynthetic process
Biological Process GO:0007399 nervous system development
Biological Process GO:0043200 response to amino acid
Biological Process GO:0046686 response to cadmium ion
Biological Process GO:0031667 response to nutrient levels
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0034612 response to tumor necrosis factor
Biological Process GO:0009410 response to xenobiotic stimulus
molecular function GO:0005524 ATP binding
molecular function GO:0043295 glutathione binding
molecular function GO:0004363 glutathione synthase activity
molecular function GO:0016594 glycine binding
molecular function GO:0042802 identical protein binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-156590 Glutathione conjugation
R-HSA-1643685 Disease
R-HSA-174403 Glutathione synthesis and recycling
R-HSA-211859 Biological oxidations
R-HSA-5579006 Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes
R-HSA-5668914 Diseases of metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007684 BXGD000472 Central Nervous System Infection Infections; Nervous System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0017654 BXGD001136 Glomerular Filtration Rate
C0018078 BXGD001170 Gonococcal urethritis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024440 BXGD001774 Macular Edema, Cystoid Eye Diseases
C0024667 BXGD001794 Animal Mammary Neoplasms Neoplasms; Animal Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0026636 BXGD001911 Mouth Diseases Stomatognathic Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0040580 BXGD002877 Tracheal Diseases Respiratory Tract Diseases
C0041976 BXGD002946 Urethritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042693 BXGD002996 Violence
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0162351 BXGD003938 Contact hypersensitivity Skin and Connective Tissue Diseases
C0162534 BXGD003953 Prion Diseases Infections; Nervous System Diseases
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0234376 BXGD004659 Action Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0268523 BXGD005969 Glutamate-cysteine ligase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268525 BXGD005971 5-oxoprolinase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0271051 BXGD006153 Macular retinal edema Eye Diseases
C0342538 BXGD007498 Constitutional delay of growth and puberty
C0398746 BXGD008224 Gluthathione synthetase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0429097 BXGD008648 QRS complex feature
C0520572 BXGD009093 Enzymopathy Nutritional and Metabolic Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0575059 BXGD009510 Spastic tetraparesis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0677660 BXGD009725 Emotional problems Mental Disorders
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0740749 BXGD010007 Chronic metabolic acidosis Nutritional and Metabolic Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0877008 BXGD011325 Enzyme inhibition disorder
C0919677 BXGD011435 Protein C measurement
C1112709 BXGD011682 non-gonococcal urethritis (NGU) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C1168438 BXGD011793 Protein C antigen measurement
C1257925 BXGD011814 Mammary Carcinoma, Animal Neoplasms; Animal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1856399 BXGD015599 Glutathione Synthetase Deficiency of Erythrocytes, Hemolytic Anemia due to
C3279658 BXGD018766 Glyoxalase deficiency
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4025789 BXGD021790 Psychotic mentation Mental Disorders
C4281802 BXGD022417 Spongiform encephalopathy Infections; Nervous System Diseases
C4703642 BXGD023674 Increased level of L-pyroglutamic acid in urine
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000989 Glutathione 307.32
BXGC0002588 Magnesium 24.31
BXGC0002616 Copper 63.55
BXGC0002630 gamma-Glutamyl-cysteine 250.27
BXGC0006271 L-Cysteine 121.16
BXGC0033112 Acetylcysteine 163.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein