Showing entry for Protoporphyrinogen oxidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010791
Protein NameProtoporphyrinogen oxidase
Uniport IdP50336
GenePPOX
Gene Id5498
DomainAmino_oxidase
Pfam PF01593  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00860 Porphyrin and chlorophyll metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006783 heme biosynthetic process
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0006779 porphyrin-containing compound biosynthetic process
Biological Process GO:0006782 protoporphyrinogen IX biosynthetic process
Biological Process GO:0042493 response to drug
molecular function GO:0050660 flavin adenine dinucleotide binding
molecular function GO:0016491 oxidoreductase activity
molecular function GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity
cellular component GO:0031305 integral component of mitochondrial inner membrane
cellular component GO:0031304 intrinsic component of mitochondrial inner membrane
cellular component GO:0005758 mitochondrial intermembrane space
cellular component GO:0031966 mitochondrial membrane
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-189445 Metabolism of porphyrins
R-HSA-189451 Heme biosynthesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0008767 BXGD000570 Cicatrization Pathological Conditions, Signs and Symptoms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0021141 BXGD001485 Inappropriate ADH Syndrome Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027583 BXGD002001 Nematode infections Infections
C0032708 BXGD002368 Disorders of Porphyrin Metabolism Nutritional and Metabolic Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039231 BXGD002799 Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151861 BXGD003491 Porphyruria Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162531 BXGD003950 Hereditary Coproporphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162532 BXGD003951 Variegate Porphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162533 BXGD003952 Porphyrias, Hepatic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162565 BXGD003957 Acute intermittent porphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162568 BXGD003959 Erythropoietic Protoporphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0232488 BXGD004547 Abdominal colic Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0233763 BXGD004611 Hallucinations, Visual Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0268328 BXGD005898 Porphobilinogen synthase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0271683 BXGD006234 Polyneuropathy, Motor Nervous System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0342860 BXGD007567 Homozygous variegate porphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0349506 BXGD007912 Photosensitivity of skin Skin and Connective Tissue Diseases
C0349530 BXGD007916 Early gastric cancer Digestive System Diseases; Neoplasms
C0423757 BXGD008504 Thin skin
C0522153 BXGD009192 Urine Discoloration Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0522224 BXGD009198 Paralysed Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1279945 BXGD012124 Acute interstitial pneumonia Respiratory Tract Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1836735 BXGD014155 hypopigmented skin patch Skin and Connective Tissue Diseases
C2132198 BXGD016930 Abnormal blistering of the skin
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2936779 BXGD018134 Hydroxymethylbilane Synthase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C2936913 BXGD018151 Porphyria, South African type
C3489396 BXGD018929 Hypogonadism, Isolated Hypogonadotropic Endocrine System Diseases
C3887485 BXGD019877 MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein