Showing entry for Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010840
Protein NameCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Uniport IdP51160
GenePDE6C
Gene Id5146
DomainGAF; PDEase_I
Pfam PF01590   PF00233  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007603 phototransduction, visible light
Biological Process GO:0046549 retinal cone cell development
Biological Process GO:0007601 visual perception
molecular function GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
molecular function GO:0030553 cGMP binding
molecular function GO:0046872 metal ion binding
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0009398 BXGD000604 Color vision defect Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0015310 BXGD000976 Exotropia Eye Diseases; Nervous System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0020490 BXGD001403 Hyperopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0152191 BXGD003556 Scotoma, Central Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0152200 BXGD003557 Achromatopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0236733 BXGD004822 Amphetamine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0236804 BXGD004835 Amphetamine Addiction Chemically-Induced Disorders; Mental Disorders
C0236807 BXGD004836 Amphetamine Abuse Chemically-Induced Disorders; Mental Disorders
C0271092 BXGD006161 Progressive cone dystrophy (without rod involvement) Eye Diseases
C0271388 BXGD006196 Pendular Nystagmus Eye Diseases; Nervous System Diseases
C0302129 BXGD006830 Achromatopsia 1 Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0339526 BXGD007259 Autosomal recessive retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339537 BXGD007264 Cone monochromatism Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0476397 BXGD008991 Electroretinogram abnormal
C0543968 BXGD009303 Cone dysfunction syndrome
C0730290 BXGD009946 Cone Dystrophy Eye Diseases
C0858618 BXGD011184 Dyschromatopsia
C0877008 BXGD011325 Enzyme inhibition disorder
C1288283 BXGD012175 Atrophoderma maculatum Skin and Connective Tissue Diseases
C1840457 BXGD014472 Retinal pigment epithelial atrophy
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2673946 BXGD017234 Foveal hypoplasia (finding)
C2751308 BXGD017702 CONE DYSTROPHY 4 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C2751309 BXGD017703 Achromatopsia 5 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C3278975 BXGD018749 Attenuation of retinal blood vessels
C3665342 BXGD019277 Progressive Cone Dystrophy Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4024799 BXGD021424 Granular macular appearance
C4085590 BXGD022119 Cone-Rod Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001502 Caffeine 194.19
BXGC0023305 Icariside Ii 514.18
BXGC0036504 Icaritin 368.13
BXGC0047302 Icariin 676.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein