Showing entry for 3-hydroxy-3-methylglutaryl-coenzyme A reductase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010870
Protein Name3-hydroxy-3-methylglutaryl-coenzyme A reductase
Uniport IdP51639
GeneHmgcr
Gene Id25675
DomainHMG-CoA_red; Sterol-sensing
Pfam PF00368   PF12349  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0038183 bile acid signaling pathway
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0015936 coenzyme A metabolic process
Biological Process GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway
Biological Process GO:0008299 isoprenoid biosynthetic process
Biological Process GO:0045445 myoblast differentiation
Biological Process GO:1900222 negative regulation of amyloid-beta clearance
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0097756 negative regulation of blood vessel diameter
Biological Process GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0043407 negative regulation of MAP kinase activity
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:0050709 negative regulation of protein secretion
Biological Process GO:0010664 negative regulation of striated muscle cell apoptotic process
Biological Process GO:0061045 negative regulation of wound healing
Biological Process GO:0010666 positive regulation of cardiac muscle cell apoptotic process
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0048643 positive regulation of skeletal muscle tissue development
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:0032874 positive regulation of stress-activated MAPK cascade
Biological Process GO:0070723 response to cholesterol
Biological Process GO:0045471 response to ethanol
Biological Process GO:0007584 response to nutrient
Biological Process GO:0031667 response to nutrient levels
Biological Process GO:0016126 sterol biosynthetic process
Biological Process GO:0070328 triglyceride homeostasis
Biological Process GO:0006743 ubiquinone metabolic process
Biological Process GO:0008542 visual learning
molecular function GO:0120225 coenzyme A binding
molecular function GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
molecular function GO:0042282 hydroxymethylglutaryl-CoA reductase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0070402 NADPH binding
molecular function GO:0051721 protein phosphatase 2A binding
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005778 peroxisomal membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002599 2-Propene-1-sulfinothiocic-acids 2-propenyl ester 162.27
BXGC0002904 beta-Hydroxy-beta-methylglutaric acid 162.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein