Showing entry for Hexokinase-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010955
Protein NameHexokinase-3
Uniport IdP52790
GeneHK3
Gene Id3101
DomainHexokinase_1; Hexokinase_2
Pfam PF00349   PF03727  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00010 Glycolysis / Gluconeogenesis
1. Metabolism 1.1 Carbohydrate metabolism hsa00051 Fructose and mannose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00052 Galactose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00500 Starch and sucrose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00520 Amino sugar and nucleotide sugar metabolism
1. Metabolism 1.10 Biosynthesis of other secondary metabolites hsa00524 Neomycin, kanamycin and gentamicin biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
3. Environmental Information Processing 3.2 Signal transduction hsa04066 HIF-1 signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04930 Type II diabetes mellitus
5. Organismal Systems 5.4 Digestive system hsa04973 Carbohydrate digestion and absorption
6. Human Diseases 6.1 Cancers: Overview hsa05230 Central carbon metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0001678 cellular glucose homeostasis
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0051156 glucose 6-phosphate metabolic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0043312 neutrophil degranulation
molecular function GO:0005524 ATP binding
molecular function GO:0008865 fructokinase activity
molecular function GO:0004340 glucokinase activity
molecular function GO:0005536 glucose binding
molecular function GO:0004396 hexokinase activity
molecular function GO:0019158 mannokinase activity
cellular component GO:0005829 cytosol
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0005739 mitochondrion
cellular component GO:0034774 secretory granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
R-HSA-70171 Glycolysis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0086565 BXGD003295 Liver Dysfunction Digestive System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C2242776 BXGD017001 Plexiform leiomyoma
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005625 alpha-D-Glucopyranose 180.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein