Showing entry for Voltage-dependent L-type calcium channel subunit beta-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011039
Protein NameVoltage-dependent L-type calcium channel subunit beta-3
Uniport IdP54284
GeneCACNB3
Gene Id784
DomainGuanylate_kin; VGCC_beta4_N
Pfam PF00625   PF12052  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0060402 calcium ion transport into cytosol
Biological Process GO:0061337 cardiac conduction
Biological Process GO:0090650 cellular response to oxygen-glucose deprivation
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
Biological Process GO:0051899 membrane depolarization
Biological Process GO:1905788 negative regulation of detection of mechanical stimulus involved in sensory perception of touch
Biological Process GO:1901386 negative regulation of voltage-gated calcium channel activity
Biological Process GO:0007528 neuromuscular junction development
Biological Process GO:2000463 positive regulation of excitatory postsynaptic potential
Biological Process GO:1901843 positive regulation of high voltage-gated calcium channel activity
Biological Process GO:0090314 positive regulation of protein targeting to membrane
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:1902630 regulation of membrane hyperpolarization
Biological Process GO:0098903 regulation of membrane repolarization during action potential
Biological Process GO:1901385 regulation of voltage-gated calcium channel activity
Biological Process GO:0050852 T cell receptor signaling pathway
molecular function GO:0005246 calcium channel regulator activity
molecular function GO:0008331 high voltage-gated calcium channel activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0005245 voltage-gated calcium channel activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005829 cytosol
cellular component GO:1990454 L-type voltage-gated calcium channel complex
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
cellular component GO:0005891 voltage-gated calcium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112308 Presynaptic depolarization and calcium channel opening
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-163685 Integration of energy metabolism
R-HSA-163685 Integration of energy metabolism
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-419037 NCAM1 interactions
R-HSA-422356 Regulation of insulin secretion
R-HSA-422356 Regulation of insulin secretion
R-HSA-422475 Axon guidance
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0010093 BXGD000652 Corpus Luteum Cyst Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029927 BXGD002182 Ovarian Cysts Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C3853779 BXGD019822 Neonatal Alloimmune Thrombocytopenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003611 Latex 416.57
BXGC0006372 Ergocalciferol 396.65
BXGC0007525 (-)-Menthol 156.27
BXGC0024988 Nifedipine 346.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein