Showing entry for Voltage-dependent calcium channel subunit alpha-2/delta-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011040
Protein NameVoltage-dependent calcium channel subunit alpha-2/delta-1
Uniport IdP54289
GeneCACNA2D1
Gene Id781
DomainVGCC_alpha2; VWA; VWA_N
Pfam PF08473   PF00092   PF08399  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0098703 calcium ion import across plasma membrane
Biological Process GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0060402 calcium ion transport into cytosol
Biological Process GO:0061337 cardiac conduction
Biological Process GO:0086002 cardiac muscle cell action potential involved in contraction
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0086048 membrane depolarization during bundle of His cell action potential
Biological Process GO:1901843 positive regulation of high voltage-gated calcium channel activity
Biological Process GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Biological Process GO:0051924 regulation of calcium ion transport
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:0098903 regulation of membrane repolarization during action potential
Biological Process GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
molecular function GO:0046872 metal ion binding
molecular function GO:0005245 voltage-gated calcium channel activity
cellular component GO:0070062 extracellular exosome
cellular component GO:1990454 L-type voltage-gated calcium channel complex
cellular component GO:0005886 plasma membrane
cellular component GO:0016529 sarcoplasmic reticulum
cellular component GO:0005891 voltage-gated calcium channel complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0011071 BXGD000696 Sudden death Pathological Conditions, Signs and Symptoms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018810 BXGD001231 heart rate
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024591 BXGD001789 Malignant hyperpyrexia due to anesthesia Pathological Conditions, Signs and Symptoms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030591 BXGD002247 Paroxysmal ventricular tachycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0037052 BXGD002662 Sick Sinus Syndrome Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038870 BXGD002782 Neuralgia, Supraorbital Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039240 BXGD002804 Supraventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042656 BXGD002995 Neuralgia, Vidian Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085614 BXGD003205 First degree atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085615 BXGD003206 Right bundle branch block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151879 BXGD003496 Shortened QT interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155707 BXGD003813 Trifascicular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162701 BXGD003978 Polysomnography
C0175702 BXGD004008 Williams Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0234230 BXGD004635 Pain, Burning Pathological Conditions, Signs and Symptoms
C0234238 BXGD004637 Ache Pathological Conditions, Signs and Symptoms
C0234247 BXGD004642 Neuralgia, Atypical Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234249 BXGD004643 Neuralgia, Stump Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234254 BXGD004648 Radiating pain Pathological Conditions, Signs and Symptoms
C0264893 BXGD005433 Nodal rhythm disorder Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0348626 BXGD007878 Other specified cardiac arrhythmias Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0423711 BXGD008498 Neuralgia, Perineal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0423712 BXGD008499 Neuralgia, Iliohypogastric Nerve Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428908 BXGD008641 Sinus Node Dysfunction (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0428977 BXGD008644 Bradycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0458257 BXGD008905 Pain, Splitting Pathological Conditions, Signs and Symptoms
C0458259 BXGD008906 Pain, Crushing Pathological Conditions, Signs and Symptoms
C0520886 BXGD009118 ST segment elevation (finding) Cardiovascular Diseases
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751371 BXGD010415 Neuralgia, Ilioinguinal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751372 BXGD010416 Nerve Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751373 BXGD010417 Paroxysmal Nerve Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751407 BXGD010429 Pain, Migratory Pathological Conditions, Signs and Symptoms
C0751408 BXGD010430 Suffering, Physical Pathological Conditions, Signs and Symptoms
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1399226 BXGD013003 Ectopic rhythm Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1865020 BXGD016286 Short QT Syndrome 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2348199 BXGD017054 Short Qt Syndrome Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2748542 BXGD017596 CARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C2751898 BXGD017749 Ventricular Fibrillation, Paroxysmal Familial, 1 Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2931783 BXGD018061 Amelogenesis imperfecta nephrocalcinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Stomatognathic Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3160712 BXGD018467 Palpitations, CTCAE
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3715208 BXGD019451 AV Block First Degree by ECG Finding Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4551804 BXGD023411 Brugada Syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003611 Latex 416.57
BXGC0006372 Ergocalciferol 396.65
BXGC0024988 Nifedipine 346.12
BXGC0043126 Nicardipine 479.21
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein