Showing entry for Sodium/potassium-transporting ATPase subunit gamma


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011070
Protein NameSodium/potassium-transporting ATPase subunit gamma
Uniport IdP54710
GeneFXYD2
Gene Id486
DomainATP1G1_PLM_MAT8
Pfam PF02038  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.5 Excretory system hsa04960 Aldosterone-regulated sodium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04964 Proximal tubule bicarbonate reclamation
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04973 Carbohydrate digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04974 Protein digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:2000649 regulation of sodium ion transmembrane transporter activity
Biological Process GO:0036376 sodium ion export across plasma membrane
Biological Process GO:0055085 transmembrane transport
molecular function GO:0099106 ion channel regulator activity
molecular function GO:0005391 sodium:potassium-exchanging ATPase activity
molecular function GO:0017080 sodium channel regulator activity
molecular function GO:0005215 transporter activity
cellular component GO:0070062 extracellular exosome
cellular component GO:0005886 plasma membrane
cellular component GO:0005890 sodium:potassium-exchanging ATPase complex
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-5663205 Infectious disease
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020599 BXGD001441 Hypocalciuria Nutritional and Metabolic Diseases
C0020621 BXGD001449 Hypokalemia Nutritional and Metabolic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024473 BXGD001778 Magnesium Deficiency Nutritional and Metabolic Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033802 BXGD002425 Pseudogout Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151723 BXGD003466 Hypomagnesemia Nutritional and Metabolic Diseases
C0268448 BXGD005950 Primary hypomagnesemia (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0458960 BXGD008909 Peripheral neuropathic pain
C0553730 BXGD009417 Calcium pyrophosphate deposition disease Musculoskeletal Diseases
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1835171 BXGD014015 Hypomagnesemia 2, renal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
C4552839 BXGD023527 Hypomagnesemia, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003690 Glucokinin 764.94
BXGC0015208 Getiacaulein 288.06
BXGC0020220 panaxatriol 476.39
BXGC0022544 Digoxin 780.43
BXGC0023461 methylswertianin 288.06
BXGC0025733 1,3,5,6-Tetrahydroxyxanthen-9-One 260.03
BXGC0036400 1,3,5-Trihydroxyxanthen-9-One 244.04
BXGC0039507 Digitoxigenin 374.25
BXGC0044158 3,4,5-Trihydroxyxanthen-9-One 244.04
BXGC0048644 1,2,3,7-Tetramethoxyxanthone 316.09
BXGC0050699 \N 260.03
BXGC0051524 Ouabain 584.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein