Showing entry for Transitional endoplasmic reticulum ATPase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011103
Protein NameTransitional endoplasmic reticulum ATPase
Uniport IdP55072
GeneVCP
Gene Id7415
DomainA; A_lid_3; CDC48_2; CDC48_N; Vps4_C
Pfam PF00004   PF17862   PF02933   PF02359   PF09336  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05134 Legionellosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0070842 aggresome assembly
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0097352 autophagosome maturation
Biological Process GO:0006914 autophagy
Biological Process GO:1903843 cellular response to arsenite ion
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0006281 DNA repair
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0061857 endoplasmic reticulum stress-induced pre-emptive quality control
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0030968 endoplasmic reticulum unfolded protein response
Biological Process GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0071712 ER-associated misfolded protein catabolic process
Biological Process GO:0070987 error-free translesion synthesis
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0072389 flavin adenine dinucleotide catabolic process
Biological Process GO:0016236 macroautophagy
Biological Process GO:0051228 mitotic spindle disassembly
Biological Process GO:0006734 NADH metabolic process
Biological Process GO:0045879 negative regulation of smoothened signaling pathway
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:2001171 positive regulation of ATP biosynthetic process
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:1903007 positive regulation of Lys63-specific deubiquitinase activity
Biological Process GO:0010918 positive regulation of mitochondrial membrane potential
Biological Process GO:1903862 positive regulation of oxidative phosphorylation
Biological Process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0031334 positive regulation of protein-containing complex assembly
Biological Process GO:1903006 positive regulation of protein K63-linked deubiquitination
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0006457 protein folding
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:1903715 regulation of aerobic respiration
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0030970 retrograde protein transport, ER to cytosol
Biological Process GO:0035617 stress granule disassembly
Biological Process GO:0019985 translesion synthesis
Biological Process GO:0055085 transmembrane transport
Biological Process GO:0030433 ubiquitin-dependent ERAD pathway
Biological Process GO:0019079 viral genome replication
molecular function GO:0043531 ADP binding
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:1904288 BAT3 complex binding
molecular function GO:0035800 deubiquitinase activator activity
molecular function GO:0042802 identical protein binding
molecular function GO:0036435 K48-linked polyubiquitin modification-dependent protein binding
molecular function GO:0008289 lipid binding
molecular function GO:0042288 MHC class I protein binding
molecular function GO:0031593 polyubiquitin modification-dependent protein binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0003723 RNA binding
molecular function GO:0044389 ubiquitin-like protein ligase binding
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:1990381 ubiquitin-specific protease binding
cellular component GO:1904949 ATPase complex
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0005737 cytoplasm
cellular component GO:0010494 cytoplasmic stress granule
cellular component GO:0005829 cytosol
cellular component GO:0036513 Derlin-1 retrotranslocation complex
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005811 lipid droplet
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0000502 proteasome complex
cellular component GO:0032991 protein-containing complex
cellular component GO:0034774 secretory granule lumen
cellular component GO:0035861 site of double-strand break
cellular component GO:0045202 synapse
cellular component GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex
cellular component GO:1990730 VCP-NSFL1C complex
Reactome
Pathway Id Pathway Name
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
R-HSA-110320 Translesion Synthesis by POLH
R-HSA-162582 Signal Transduction
R-HSA-1632852 Macroautophagy
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-2262752 Cellular responses to stress
R-HSA-3371511 HSF1 activation
R-HSA-3371556 Cellular response to heat stress
R-HSA-382551 Transport of small molecules
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-392499 Metabolism of proteins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5387390 Hh mutants abrogate ligand secretion
R-HSA-5619084 ABC transporter disorders
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5688426 Deubiquitination
R-HSA-5689877 Josephin domain DUBs
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-597592 Post-translational protein modification
R-HSA-6798695 Neutrophil degranulation
R-HSA-73893 DNA Damage Bypass
R-HSA-73894 DNA Repair
R-HSA-8852135 Protein ubiquitination
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-8876725 Protein methylation
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9612973 Autophagy
R-HSA-9646399 Aggrephagy
R-HSA-9663891 Selective autophagy
R-HSA-9678108 SARS-CoV-1 Infection
R-HSA-9678110 Attachment and Entry
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679506 SARS-CoV Infections
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694614 Attachment and Entry
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0002018 BXGD000097 Alexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003537 BXGD000208 Aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003550 BXGD000210 Broca Aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003635 BXGD000214 Apraxias Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0004604 BXGD000278 Back Pain Pathological Conditions, Signs and Symptoms
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007121 BXGD000436 Bronchogenic Carcinoma Neoplasms; Respiratory Tract Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013528 BXGD000851 Echolalia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0014518 BXGD000921 Toxic Epidermal Necrolysis Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014850 BXGD000957 Esophageal Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0015644 BXGD001008 Muscular fasciculation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015732 BXGD001018 Fecal Incontinence Digestive System Diseases
C0016663 BXGD001071 Pathological fracture Wounds and Injuries
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019559 BXGD001335 Hip joint pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0023015 BXGD001601 Language Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0023066 BXGD001605 Laryngospasm Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024003 BXGD001726 Lordosis Musculoskeletal Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024408 BXGD001768 Machado-Joseph Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0024530 BXGD001783 Malaria Infections
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026884 BXGD001945 Mutism Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029401 BXGD002135 Osteitis Deformans Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033626 BXGD002412 Protein Deficiency Nutritional and Metabolic Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0034935 BXGD002497 Babinski Reflex
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037772 BXGD002703 Spastic Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037773 BXGD002704 Spastic Paraplegia, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0038325 BXGD002745 Stevens-Johnson Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0039494 BXGD002814 Temporomandibular Joint Disorders Musculoskeletal Diseases; Stomatognathic Diseases
C0039496 BXGD002815 Temporomandibular Joint Dysfunction Syndrome Musculoskeletal Diseases; Stomatognathic Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040588 BXGD002879 Tracheoesophageal Fistula Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Respiratory Tract Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0043124 BXGD003031 West Nile Fever Infections; Nervous System Diseases
C0043352 BXGD003045 Xerostomia Stomatognathic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0086543 BXGD003294 Cataract Eye Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0151849 BXGD003486 Alkaline phosphatase raised Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206659 BXGD004222 Embryonal Carcinoma Neoplasms
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0220620 BXGD004299 Gastrointestinal Carcinoid Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0221166 BXGD004397 Paraparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0221629 BXGD004467 Proximal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0231341 BXGD004492 Premature aging syndrome Pathological Conditions, Signs and Symptoms
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0231687 BXGD004509 Spastic gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231712 BXGD004519 Waddling gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233522 BXGD004585 Inappropriate behavior Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234133 BXGD004624 Extrapyramidal sign
C0234144 BXGD004625 Dysgraphia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234410 BXGD004665 Physiologic disinhibition
C0235025 BXGD004713 Peripheral motor neuropathy Nervous System Diseases
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0238190 BXGD004890 Inclusion Body Myositis (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0239067 BXGD004961 Difficulty walking up stairs Pathological Conditions, Signs and Symptoms
C0239548 BXGD004984 Fasciculation, Tongue Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0240083 BXGD005017 Abnormal joint morphology Musculoskeletal Diseases
C0240679 BXGD005049 Pelvic girdle muscle atrophy
C0240735 BXGD005052 Personality Change Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0240953 BXGD005067 Winged scapula
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0241816 BXGD005115 Global brain atrophy
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242647 BXGD005184 Mucosa-Associated Lymphoid Tissue Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0266999 BXGD005725 Vesicular Stomatitis Infections; Stomatognathic Diseases; Animal Diseases
C0268398 BXGD005933 Familial lichen amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0270790 BXGD006105 Quadriparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270914 BXGD006131 Hereditary Motor and Sensory-Neuropathy Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279584 BXGD006641 Childhood B Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279593 BXGD006644 Adult B Acute Lymphoblastic Leukemia
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280313 BXGD006737 Squamous cell carcinoma of oropharynx Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282513 BXGD006808 Primary Progressive Aphasia (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0349588 BXGD007933 Short stature
C0349636 BXGD007941 Pre B-cell acute lymphoblastic leukemia
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0391957 BXGD008019 idiopathic epilepsy
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0410198 BXGD008416 Proximal myopathy Musculoskeletal Diseases; Nervous System Diseases
C0424290 BXGD008523 Compulsive hoarding Behavior and Behavior Mechanisms
C0424296 BXGD008525 Social disinhibition Mental Disorders
C0427063 BXGD008602 Shoulder girdle weakness
C0427064 BXGD008603 Pelvic girdle weakness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476254 BXGD008984 Dyslexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0476408 BXGD008994 Reduced vital capacity
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0521158 BXGD009130 Recurrent tumor
C0521670 BXGD009160 Cranial nerve compression Nervous System Diseases; Wounds and Injuries
C0522224 BXGD009198 Paralysed Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0542223 BXGD009274 Loss of speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0558845 BXGD009459 Reflex, Ankle, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0587246 BXGD009616 Muscle weakness of limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686353 BXGD009833 Muscular Dystrophies, Limb-Girdle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0750927 BXGD010254 Apraxia, Developmental Verbal Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751072 BXGD010312 Frontotemporal Lobar Degeneration Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751337 BXGD010393 X-Linked Emery-Dreifuss Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0751576 BXGD010508 Partial Paralysis (Paresis) Vocal Cords Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0751706 BXGD010559 Primary Progressive Nonfluent Aphasia Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0751713 BXGD010564 Inclusion Body Myopathy, Sporadic Musculoskeletal Diseases; Nervous System Diseases
C0751783 BXGD010592 Lafora Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751882 BXGD010626 Myasthenic Syndromes, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0869474 BXGD011306 Dyscalculia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0917981 BXGD011423 Progressive Muscular Atrophy Nervous System Diseases
C0919974 BXGD011449 Abulia
C0948163 BXGD011511 Leukoaraiosis Pathological Conditions, Signs and Symptoms
C0973461 BXGD011595 Dysphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1096184 BXGD011607 West Nile viral infection Infections; Nervous System Diseases
C1136179 BXGD011712 Hammer Toe Musculoskeletal Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1184923 BXGD011800 Lumbar hyperlordosis Musculoskeletal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1274933 BXGD012051 Drug-Induced Stevens Johnson Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C1285162 BXGD012167 Degenerative disorder Pathological Conditions, Signs and Symptoms
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332218 BXGD012511 Adult Type Ovarian Granulosa Cell Tumor Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1368019 BXGD012892 Paget Disease Neoplasms
C1370419 BXGD012910 Ovarian Granulosa Cell Tumor Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1389113 BXGD012965 Generalized amyotrophy
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1654637 BXGD013484 androgen independent prostate cancer
C1720037 BXGD013665 Supranuclear gaze palsy
C1833662 BXGD013936 INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE AND FRONTOTEMPORAL DEMENTIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders
C1833667 BXGD013937 Elevated alkaline phosphatase of bone origin
C1834536 BXGD013977 Weakness of the intrinsic hand muscles
C1834582 BXGD013982 MYELOPROLIFERATIVE SYNDROME, TRANSIENT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Hemic and Lymphatic Diseases
C1836003 BXGD014069 Facial diplegia Infections; Nervous System Diseases; Stomatognathic Diseases
C1836150 BXGD014082 Gait imbalance
C1836696 BXGD014151 Lower limb hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1836940 BXGD014182 Thickened nuchal skin fold
C1838244 BXGD014304 TIBIAL MUSCULAR DYSTROPHY, TARDIVE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1838320 BXGD014310 Hyperorality Behavior and Behavior Mechanisms
C1839042 BXGD014355 Upper motor neuron dysfunction
C1839615 BXGD014390 X-linked myopathy with excessive autophagy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1842587 BXGD014526 Sensory axonal neuropathy
C1843013 BXGD014549 Alzheimer disease, familial, type 3 Nervous System Diseases; Mental Disorders
C1843663 BXGD014600 Urinary bladder sphincter dysfunction
C1843700 BXGD014604 Increased variability in muscle fiber diameter
C1843792 BXGD014606 FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED
C1846566 BXGD014829 Degeneration of the lateral corticospinal tracts
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1847651 BXGD014881 Rapidly progressive dementia Nervous System Diseases; Mental Disorders
C1847766 BXGD014888 Shoulder girdle muscle atrophy
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848736 BXGD014970 Distal amyotrophy
C1849134 BXGD015010 Impaired vibration sensation in the lower limbs
C1849485 BXGD015057 Neuronal loss in the cerebral cortex
C1850900 BXGD015186 Familial primary gastric lymphoma Digestive System Diseases; Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1853926 BXGD015365 NONAKA MYOPATHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1853932 BXGD015366 Rimmed vacuoles on biopsy
C1854657 BXGD015418 Limb fasciculations Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854838 BXGD015438 Progressive neurologic deterioration Mental Disorders
C1857640 BXGD015726 Decreased nerve conduction velocity
C1861028 BXGD016010 Esophageal atresia with or without tracheoesophageal fistula Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C1861403 BXGD016045 Variable expressivity
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C1862941 BXGD016145 Amyotrophic Lateral Sclerosis, Sporadic Nutritional and Metabolic Diseases; Nervous System Diseases
C1863351 BXGD016167 Calvarial hyperostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1864716 BXGD016245 Intrinsic hand muscle atrophy
C1865412 BXGD016326 Abnormal lower motor neuron morphology
C1866141 BXGD016379 Foot dorsiflexor weakness
C1866772 BXGD016424 Abnormal nerve conduction velocity
C1867864 BXGD016472 Poor fine motor coordination
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963060 BXGD016679 Agitation, CTCAE 3.0
C1963077 BXGD016680 Bone Pain, CTCAE 3.0
C1963167 BXGD016686 Memory Impairment, CTCAE 3.0
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2718017 BXGD017522 TDP-43 Proteinopathies Nutritional and Metabolic Diseases; Nervous System Diseases
C2749625 BXGD017629 Motor axonal neuropathy
C2919142 BXGD017867 Short Stature, CTCAE
C2931230 BXGD017985 Vacuolar myopathy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C2931820 BXGD018067 Inclusion body myopathy, autosomal dominant Pathological Conditions, Signs and Symptoms; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3151403 BXGD018421 AMYOTROPHIC LATERAL SCLEROSIS 14 WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA
C3152097 BXGD018457 AMYOTROPHIC LATERAL SCLEROSIS 14 WITHOUT FRONTOTEMPORAL DEMENTIA
C3266164 BXGD018599 Dropped head syndrome
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3539781 BXGD019086 Progressive cGVHD
C3658301 BXGD019259 Mycoplasma-Induced Stevens-Johnson Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C3658302 BXGD019260 Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3805574 BXGD019481 Increased fracture rate
C3811918 BXGD019664 GRN-related frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C3887612 BXGD019905 Psychomotor Agitation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C3887640 BXGD019908 Astrocytosis Pathological Conditions, Signs and Symptoms
C3888102 BXGD019952 Frontotemporal Dementia With Motor Neuron Disease Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C4011788 BXGD020116 Behavioral variant of frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C4014650 BXGD020156 Abnormal mitochondrial morphology
C4020732 BXGD020474 Mitochondrial abnormalities
C4020828 BXGD020485 Increased spinal bone density
C4020847 BXGD020486 Abnormality of pelvic girdle bone morphology
C4021082 BXGD020543 Fatty replacement of skeletal muscle
C4021165 BXGD020570 Abnormality of long bone morphology
C4021528 BXGD020655 Pelvic girdle amyotrophy
C4021584 BXGD020686 Frontotemporal cerebral atrophy
C4021726 BXGD020735 EMG: myopathic abnormalities Musculoskeletal Diseases; Nervous System Diseases
C4021727 BXGD020736 EMG: neuropathic changes
C4021799 BXGD020789 Restrictive behavior
C4022587 BXGD020928 Fatigable weakness of respiratory muscles
C4022588 BXGD020929 Fatigable weakness of swallowing muscles
C4022798 BXGD021001 Abnormal brain FDG positron emission tomography
C4023052 BXGD021085 Ubiquitin-positive cerebral inclusion bodies
C4023470 BXGD021195 EEG with continuous slow activity
C4024608 BXGD021339 Necrotizing myopathy Musculoskeletal Diseases; Nervous System Diseases
C4024896 BXGD021461 Motor neuron atrophy
C4024936 BXGD021486 Temporal cortical atrophy
C4024956 BXGD021499 Grammar-specific speech disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4024965 BXGD021506 Frontal cortical atrophy
C4025076 BXGD021543 Abnormality of hand joint mobility Musculoskeletal Diseases
C4025347 BXGD021649 Weakness of muscles of respiration Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C4025614 BXGD021695 EMG: chronic denervation signs
C4025692 BXGD021735 Abnormality of calvarial morphology
C4025723 BXGD021757 Abnormal upper motor neuron morphology
C4025784 BXGD021786 Abnormality of the musculature of the lower limbs
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4072928 BXGD022025 Spoken Word Recognition Deficit Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4082299 BXGD022088 Bulbar palsy Nervous System Diseases
C4225244 BXGD022189 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2Y
C4225578 BXGD022281 CHARCOT-MARIE-TOOTH DISEASE, TYPE 2Y
C4551516 BXGD023333 Hip pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C4551584 BXGD023362 Brain atrophy Nervous System Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4551951 BXGD023443 Inclusion Body Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders
C4551993 BXGD023469 Amyotrophic Lateral Sclerosis, Familial Nutritional and Metabolic Diseases; Nervous System Diseases
C4552810 BXGD023525 Irritability, CTCAE
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4553743 BXGD023548 Spasticity, CTCAE
C4553765 BXGD023551 Memory Impairment, CTCAE 5.0
C4554063 BXGD023559 Bone Pain, CTCAE 5.0
C4684942 BXGD023578 Refractory Thyroid Gland Carcinoma Neoplasms; Endocrine System Diseases
C4721411 BXGD023735 Osteolysis Musculoskeletal Diseases
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4749506 BXGD024062 Adult-onset distal myopathy due to valosin containing protein mutation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000430 Gossypol 518.55
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002064 Amentoflavone 538.46
BXGC0002588 Magnesium 24.31
BXGC0002953 2-Phenethyl isothiocyanate 163.24
BXGC0003705 Chloride 35.45
BXGC0014051 Allolaurinterol 294.06
BXGC0028206 hexamethylene glycol 118.1
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein