Showing entry for Beta-secretase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011200
Protein NameBeta-secretase 1
Uniport IdP56817
GeneBACE1
Gene Id23621
DomainAsp
Pfam PF00026  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0050435 amyloid-beta metabolic process
Biological Process GO:0042987 amyloid precursor protein catabolic process
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0071280 cellular response to copper ion
Biological Process GO:0071287 cellular response to manganese ion
Biological Process GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
Biological Process GO:0006509 membrane protein ectodomain proteolysis
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0060134 prepulse inhibition
Biological Process GO:0006508 proteolysis
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
Biological Process GO:0010288 response to lead ion
Biological Process GO:0009314 response to radiation
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0004190 aspartic-type endopeptidase activity
molecular function GO:0008798 beta-aspartyl-peptidase activity
molecular function GO:0004175 endopeptidase activity
molecular function GO:0019899 enzyme binding
molecular function GO:0008233 peptidase activity
cellular component GO:0030424 axon
cellular component GO:0009986 cell surface
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0030425 dendrite
cellular component GO:0005769 early endosome
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005768 endosome
cellular component GO:0010008 endosome membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0070931 Golgi-associated vesicle lumen
cellular component GO:0098686 hippocampal mossy fiber to CA3 synapse
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005770 late endosome
cellular component GO:0005764 lysosome
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0005771 multivesicular body
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0055037 recycling endosome
cellular component GO:0008021 synaptic vesicle
cellular component GO:0005802 trans-Golgi network
Reactome
Pathway Id Pathway Name
R-HSA-392499 Metabolism of proteins
R-HSA-977225 Amyloid fiber formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004030 BXGD000246 Aspergillosis Infections
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019911 BXGD001352 Hookworm Infections Infections
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022336 BXGD001535 Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036221 BXGD002588 Mast-Cell Sarcoma Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037316 BXGD002688 Sleep Deprivation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041234 BXGD002901 Chagas Disease Infections
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042961 BXGD003017 Intestinal Volvulus Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0043395 BXGD003046 Yellow Fever Infections
C0085220 BXGD003142 Cerebral Amyloid Angiopathy Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0154319 BXGD003716 Other specified senile psychotic conditions Nervous System Diseases; Mental Disorders
C0154671 BXGD003726 Degenerative brain disorder Nervous System Diseases
C0162835 BXGD003989 Hypopigmentation disorder Skin and Connective Tissue Diseases
C0220756 BXGD004338 Niemann-Pick Disease, Type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0240059 BXGD005014 Ventricular hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265101 BXGD005454 Carotid artery occlusion Nervous System Diseases; Cardiovascular Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0546126 BXGD009328 Acute Confusional Senile Dementia Nervous System Diseases; Mental Disorders
C0677932 BXGD009736 Progressive Neoplastic Disease
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699739 BXGD009861 Sensory Neuropathy, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740304 BXGD009976 COPD exacerbation
C0746556 BXGD010144 metabolic disturbance
C0750900 BXGD010241 Alzheimer's Disease, Focal Onset Nervous System Diseases; Mental Disorders
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0751295 BXGD010383 Memory Loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751713 BXGD010564 Inclusion Body Myopathy, Sporadic Musculoskeletal Diseases; Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0856169 BXGD011096 Endothelial dysfunction
C0877104 BXGD011335 Retinal toxicity
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1096584 BXGD011632 Chlamydia pneumoniae Infections Infections
C1096903 BXGD011645 Sialic Acid Storage Disease, Finnish Type (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1168443 BXGD011794 Pseudocholinesterase Measurement
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1275685 BXGD012092 Avellino corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1695782 BXGD013498 Cerebral hypoperfusion
C1839735 BXGD014398 MILES-CARPENTER X-LINKED MENTAL RETARDATION SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1842937 BXGD014546 AURAL ATRESIA, CONGENITAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1843013 BXGD014549 Alzheimer disease, familial, type 3 Nervous System Diseases; Mental Disorders
C1846707 BXGD014836 SPINOCEREBELLAR ATAXIA 17 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1852467 BXGD015283 Creutzfeldt-Jakob Disease, Sporadic Infections; Nervous System Diseases; Mental Disorders
C1853926 BXGD015365 NONAKA MYOPATHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1860787 BXGD015997 DOWN SYNDROME CRITICAL REGION Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1876214 BXGD016567 ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C2900450 BXGD017854 Other Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2936349 BXGD018109 Plaque, Amyloid Pathological Conditions, Signs and Symptoms
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3539781 BXGD019086 Progressive cGVHD
C3665464 BXGD019289 Dementia due to Alzheimer's disease (disorder) Nervous System Diseases; Mental Disorders
C3805054 BXGD019458 Prodromal Alzheimer's disease
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4310512 BXGD022597 Sporadic CJD Infections; Nervous System Diseases; Mental Disorders; Animal Diseases
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721773 BXGD023768 Postoperative cognitive dysfunction
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000016 Butein 272.25
BXGC0000076 p-Coumaroyl tartaric acid glucosidic ester 150.09
BXGC0000191 Tyramine 137.18
BXGC0000204 Theophylline 180.16
BXGC0000292 Xanthotoxol 202.17
BXGC0000340 Kaempferol 286.24
BXGC0000347 Kuwanon A 420.45
BXGC0000349 Mulberrin 422.47
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000578 Herniarin 176.17
BXGC0000681 Umbelliferone 162.14
BXGC0000696 Tartaric acid 150.09
BXGC0001351 Hexahydrocurcumin 374.43
BXGC0001737 Norartocarpetin 286.24
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001820 Osthol 244.29
BXGC0001823 Morusinol 438.47
BXGC0001842 Bergapten 216.19
BXGC0001843 Bergaptol 202.17
BXGC0001873 Epicatechin 290.27
BXGC0001897 Cyclomorusin 418.44
BXGC0001960 Heraclenol 304.29
BXGC0001965 Hesperidin 610.56
BXGC0002018 Morin 302.24
BXGC0002029 Taxifolin 304.25
BXGC0002051 Scoparone 206.2
BXGC0002052 Aesculetin 178.14
BXGC0002064 Amentoflavone 538.46
BXGC0002065 Bilobetin 552.48
BXGC0002071 Apigenin 270.24
BXGC0002789 Isoimperatorin 270.28
BXGC0002801 Phellopterin 300.31
BXGC0002976 ent-Epigallocatechin 3-gallate 458.37
BXGC0003219 Oxypeucedanin hydrate 304.29
BXGC0003221 Xanthyletin 228.24
BXGC0003227 Byakangelicol 316.31
BXGC0003241 Suberosin 244.29
BXGC0003705 Chloride 35.45
BXGC0004043 1,7-bis-(4-Hydroxy-3-methoxyphenyl)-heptane-3,5-diol 376.44
BXGC0004266 2-Propanol 60.1
BXGC0004965 Rhein 284.22
BXGC0005681 Ginkgetin 566.51
BXGC0005683 Quercetin 302.24
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0005721 Bisdemethoxycurcumin 308.33
BXGC0005851 Angelicin 186.17
BXGC0005857 Isoginkgetin 566.51
BXGC0005881 Urea 60.06
BXGC0005980 Isoxanthohumol 354.4
BXGC0005982 Curcumin 368.38
BXGC0005989 Auraptene 298.38
BXGC0006068 Osthenol 230.26
BXGC0006109 2-Aminoquinoline 144.17
BXGC0006115 Xanthotoxin 216.19
BXGC0006192 Seselin 228.25
BXGC0006193 Ellagic acid 302.19
BXGC0006213 Psoralen 186.17
BXGC0006259 Isopimpinellin 246.22
BXGC0006306 Myricetin 318.24
BXGC0006326 Imperatorin 270.28
BXGC0007043 Phloroglucinol 126.11
BXGC0008177 9-Hydroxy-4-methoxypsoralen 232.19
BXGC0008178 Cnidicin 354.4
BXGC0008181 Morusin 420.45
BXGC0008707 Isoliquiritigenin 256.25
BXGC0009552 Gallocatechin 306.27
BXGC0010190 9-Hydroxy-4-(3,7-dimethyl-2,6-octadienyloxy)-psoralen 368.42
BXGC0010427 Xanthotoxol geranyl ether 338.4
BXGC0012284 Gallocatechin 3-gallate 458.37
BXGC0012348 7,7''-Di-O-Methylamentoflavone 566.12
BXGC0012913 Pentagalloyl Glucose 940.12
BXGC0013315 Leachianone A 438.2
BXGC0013582 Curcumin 368.13
BXGC0013850 Robustaflavone 538.09
BXGC0013884 DIHYDROXANTHYLETIN 230.09
BXGC0014290 3,4,5-Trihydroxy-Benzoic Acid (2S,3S)-2-(3,4-Dihydroxy-Phenyl)-5,7-Dihydroxy-Chroman-3-Yl Ester 442.09
BXGC0015368 Podocarpusflavone B 566.12
BXGC0016090 Kurarinol 456.21
BXGC0016241 onitin 248.14
BXGC0016684 Kushenol T 426.2
BXGC0016800 (E)-3,2',4'-Trihydroxychalcone 256.07
BXGC0017112 n.a 424.26
BXGC0018032 2-Hydroxychalcone 224.08
BXGC0018642 Sciadopitisin 580.14
BXGC0020316 HEVEAFLAVONE 580.14
BXGC0020560 7-O-methyl-isoginkgetin 580.14
BXGC0023281 heraclenin 286.08
BXGC0023512 Ampelopsin C 680.2
BXGC0024141 Hydrocortisone 362.21
BXGC0024291 Kayaflavone 580.14
BXGC0024810 curcumin 368.13
BXGC0024813 Demethoxycurcumin 338.12
BXGC0024867 Eugeniin 938.1
BXGC0025017 Bergamottin 338.15
BXGC0025385 8-Geranyloxy-5-Methoxypsoralen 368.16
BXGC0025488 Sequoiaflavone 552.11
BXGC0025713 Hinokiflavone 538.09
BXGC0027188 decursin 328.13
BXGC0028277 Eckol 372.05
BXGC0028411 4',7'-O-Methylamentoflavone 566.12
BXGC0029484 Cupressuflavone 538.09
BXGC0029662 Sophoraflavanone G 424.19
BXGC0029707 Byakangelicin 334.11
BXGC0029722 2,2',4'-Trihydroxychalcone 256.07
BXGC0029764 (+)-Lomatin 246.09
BXGC0031084 n.a 286.08
BXGC0031240 (2S)-2'-Methoxykurarinone 452.22
BXGC0031518 Punicalagin 1084.07
BXGC0033064 7''-O-Methylsciadopitysin 594.15
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0035692 2,2',4,4'-Tetrahydroxychalcone 272.07
BXGC0037401 Dimethylcurcumin 396.16
BXGC0037591 7-Prenyloxycoumarin 230.09
BXGC0038705 (-)-Catechingallate 442.09
BXGC0038942 Sotetsuflavone 552.11
BXGC0039572 oxypeucadanin 286.08
BXGC0040710 Podocarpusflavone A 552.11
BXGC0040733 Tetrahydrocurcumin 372.16
BXGC0042738 Columbianetin 246.09
BXGC0044013 (2S,3S)-2-(3,4,5-Trihydroxy-Phenyl)-Chroman-3,5,7-Triol 306.07
BXGC0044017 Verapamil 454.28
BXGC0046518 Chloroquine 319.18
BXGC0047054 Heraclenol 304.09
BXGC0047692 Gefitinib 446.15
BXGC0048824 latifolin 286.12
BXGC0049108 2,3-Dihydroamentoflavone 540.11
BXGC0049245 cnidilin 300.1
BXGC0049447 acetate 59.01
BXGC0050641 (?)-Davidiol A 680.2
BXGC0050739 Kurarinone 438.2
BXGC0050816 Galantamine 287.15
BXGC0050871 Decursinol 246.09
BXGC0051311 Kushenol A 408.19
BXGC0052944 7-demethylsuberosin 230.09
BXGC0053679 marmesin 246.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein