Showing entry for Neutrophil defensin 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011273
Protein NameNeutrophil defensin 3
Uniport IdP59666
GeneDEFA3
Gene Id1668
DomainDefensin_1; Defensin_propep
Pfam PF00323   PF00879  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
6. Human Diseases 6.1 Cancers: Overview hsa05202 Transcriptional misregulation in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:0019730 antimicrobial humoral response
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0050832 defense response to fungus
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0051607 defense response to virus
Biological Process GO:0002227 innate immune response in mucosa
Biological Process GO:0030520 intracellular estrogen receptor signaling pathway
Biological Process GO:0031640 killing of cells of other organism
Biological Process GO:0051673 membrane disruption in other organism
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005796 Golgi lumen
Reactome
Pathway Id Pathway Name
R-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6803157 Antimicrobial peptides
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0015929 BXGD001024 Fetal Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0023223 BXGD001621 Leg Ulcer Skin and Connective Tissue Diseases
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0085166 BXGD003136 Bacterial Vaginosis Female Urogenital Diseases and Pregnancy Complications; Infections
C0339143 BXGD007226 Thyroid associated opthalmopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0751912 BXGD010641 Paraneoplastic Encephalomyelitis Neoplasms; Nervous System Diseases
C1456868 BXGD013128 Diabetic foot ulcer Skin and Connective Tissue Diseases; Endocrine System Diseases; Cardiovascular Diseases
C1719672 BXGD013659 Severe Sepsis Pathological Conditions, Signs and Symptoms; Infections
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein