Showing entry for Signal recognition particle 54 kDa protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011346
Protein NameSignal recognition particle 54 kDa protein
Uniport IdP61011
GeneSRP54
Gene Id6729
DomainSRP54; SRP54_N; SRP_SPB
Pfam PF00448   PF02881   PF02978  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa03060 Protein export
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031017 exocrine pancreas development
Biological Process GO:0030851 granulocyte differentiation
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:0045047 protein targeting to ER
Biological Process GO:0042493 response to drug
Biological Process GO:0006614 SRP-dependent cotranslational protein targeting to membrane
Biological Process GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
Biological Process GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
molecular function GO:0008312 7S RNA binding
molecular function GO:0008144 drug binding
molecular function GO:0030942 endoplasmic reticulum signal peptide binding
molecular function GO:0019003 GDP binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0043021 ribonucleoprotein complex binding
molecular function GO:0003723 RNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0016607 nuclear speck
cellular component GO:0005634 nucleus
cellular component GO:0005786 signal recognition particle, endoplasmic reticulum targeting
Reactome
Pathway Id Pathway Name
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-72766 Translation
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002874 BXGD000134 Aplastic Anemia Hemic and Lymphatic Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0007642 BXGD000469 Cellulitis Pathological Conditions, Signs and Symptoms; Infections; Skin and Connective Tissue Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017574 BXGD001122 Gingivitis Infections; Stomatognathic Diseases
C0018916 BXGD001245 Hemangioma Neoplasms
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026985 BXGD001956 Myelodysplasia
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027709 BXGD002026 Nephrocalcinosis Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031350 BXGD002300 Pharyngitis Infections; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0035220 BXGD002512 Respiratory Distress Syndrome, Newborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0035455 BXGD002554 Rhinitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0038238 BXGD002741 Steatorrhea Digestive System Diseases; Nutritional and Metabolic Diseases
C0040021 BXGD002834 Thromboangiitis Obliterans Cardiovascular Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0085652 BXGD003224 Pyoderma Gangrenosum Skin and Connective Tissue Diseases
C0085702 BXGD003247 Monocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0149745 BXGD003356 Oral Ulcer Stomatognathic Diseases
C0149887 BXGD003380 Slipped Capital Femoral Epiphyses Musculoskeletal Diseases
C0158731 BXGD003902 Congenital pectus carinatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0232513 BXGD004553 Premature tooth loss Stomatognathic Diseases
C0235991 BXGD004802 Small for gestational age (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0239138 BXGD004966 Hip joint varus deformity - observation Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0239941 BXGD005009 Persistence of hemoglobin F
C0239998 BXGD005012 Recurrent infections Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0240340 BXGD005031 Microdontia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0265290 BXGD005503 Metaphyseal chondrodysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0267963 BXGD005796 Exocrine pancreatic insufficiency Digestive System Diseases
C0272170 BXGD006312 Shwachman syndrome
C0302511 BXGD006849 Small for gestational age fetus Pathological Conditions, Signs and Symptoms
C0349588 BXGD007933 Short stature
C0426789 BXGD008576 Short thorax
C0426790 BXGD008577 Narrow thorax
C0427543 BXGD008620 Increased blood monocyte number
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0541764 BXGD009259 Delayed bone age
C0557874 BXGD009444 Global developmental delay
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0743360 BXGD010082 Recurrent ear infections
C1442837 BXGD013060 Myocardial necrosis Cardiovascular Diseases
C1836320 BXGD014108 Proximal femoral metaphyseal irregularity
C1837066 BXGD014190 Recurrent viral infection Infections
C1844383 BXGD014628 Recurrent bacterial infection Infections
C1846154 BXGD014788 Anterior rib cupping
C1846546 BXGD014825 Recurrent sinopulmonary infections
C1848701 BXGD014967 Elevated hepatic transaminase
C1849039 BXGD014999 Metaphyseal widening
C1850083 BXGD015106 Irregular ossification at anterior rib ends
C1850087 BXGD015107 Narrow sacroiliac notch
C1853193 BXGD015312 Recurrent skin infections Infections; Skin and Connective Tissue Diseases
C1854495 BXGD015410 Recurrent infection of the gastrointestinal tract
C1855665 BXGD015524 Ovoid vertebral bodies
C1855710 BXGD015534 Bone marrow hypocellularity
C1857180 BXGD015682 Enlargement of the costochondral junction
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858981 BXGD015839 Antineutrophil antibody positivity
C1859966 BXGD015943 Neutropenia, Severe Congenital, Autosomal Dominant 1 Hemic and Lymphatic Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963099 BXGD016682 Myelodysplasia, CTCAE
C1963165 BXGD016685 Malabsorption, CTCAE
C2919142 BXGD017867 Short Stature, CTCAE
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3552526 BXGD019156 Metaphyseal sclerosis
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4025790 BXGD021791 Specific learning disability
C4025814 BXGD021806 Abnormality of the metaphysis
C4281993 BXGD022418 Neonatal respiratory distress Respiratory Tract Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4692625 BXGD023590 SHWACHMAN-DIAMOND SYNDROME 1
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0024261 Adenosine Phosphate 347.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein