Showing entry for D(2) dopamine receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011367
Protein NameD(2) dopamine receptor
Uniport IdP61169
GeneDrd2
Gene Id24318
Domain7tm_1
Pfam PF00001  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0046717 acid secretion
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0021984 adenohypophysis development
Biological Process GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
Biological Process GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0030534 adult behavior
Biological Process GO:0007628 adult walking behavior
Biological Process GO:0050482 arachidonic acid secretion
Biological Process GO:0008306 associative learning
Biological Process GO:0031223 auditory behavior
Biological Process GO:0006914 autophagy
Biological Process GO:0007409 axonogenesis
Biological Process GO:0048148 behavioral response to cocaine
Biological Process GO:0048149 behavioral response to ethanol
Biological Process GO:0048755 branching morphogenesis of a nerve
Biological Process GO:0030007 cellular potassium ion homeostasis
Biological Process GO:0021853 cerebral cortex GABAergic interneuron migration
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0042417 dopamine metabolic process
Biological Process GO:0007212 dopamine receptor signaling pathway
Biological Process GO:0042756 drinking behavior
Biological Process GO:0007631 feeding behavior
Biological Process GO:0030900 forebrain development
Biological Process GO:0002031 G protein-coupled receptor internalization
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007625 grooming behavior
Biological Process GO:1990384 hyaloid vascular plexus regression
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0007616 long-term memory
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0007194 negative regulation of adenylate cyclase activity
Biological Process GO:0045776 negative regulation of blood pressure
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0042321 negative regulation of circadian sleep/wake cycle, sleep
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0060160 negative regulation of dopamine receptor signaling pathway
Biological Process GO:0033602 negative regulation of dopamine secretion
Biological Process GO:0045824 negative regulation of innate immune response
Biological Process GO:0046676 negative regulation of insulin secretion
Biological Process GO:0051898 negative regulation of protein kinase B signaling
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0050709 negative regulation of protein secretion
Biological Process GO:0051967 negative regulation of synaptic transmission, glutamatergic
Biological Process GO:1901386 negative regulation of voltage-gated calcium channel activity
Biological Process GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure
Biological Process GO:0007270 neuron-neuron synaptic transmission
Biological Process GO:0021769 orbitofrontal cortex development
Biological Process GO:0030432 peristalsis
Biological Process GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
Biological Process GO:0043473 pigmentation
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Biological Process GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:1900168 positive regulation of glial cell-derived neurotrophic factor secretion
Biological Process GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0060124 positive regulation of growth hormone secretion
Biological Process GO:1900273 positive regulation of long-term synaptic potentiation
Biological Process GO:0045840 positive regulation of mitotic nuclear division
Biological Process GO:0040018 positive regulation of multicellular organism growth
Biological Process GO:0002052 positive regulation of neuroblast proliferation
Biological Process GO:0050769 positive regulation of neurogenesis
Biological Process GO:0002092 positive regulation of receptor internalization
Biological Process GO:0035815 positive regulation of renal sodium excretion
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0035810 positive regulation of urine volume
Biological Process GO:0099170 postsynaptic modulation of chemical synaptic transmission
Biological Process GO:0060134 prepulse inhibition
Biological Process GO:0008104 protein localization
Biological Process GO:0014059 regulation of dopamine secretion
Biological Process GO:0051584 regulation of dopamine uptake involved in synaptic transmission
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0090325 regulation of locomotion involved in locomotory behavior
Biological Process GO:0048169 regulation of long-term neuronal synaptic plasticity
Biological Process GO:0043408 regulation of MAPK cascade
Biological Process GO:0051580 regulation of neurotransmitter uptake
Biological Process GO:0043666 regulation of phosphoprotein phosphatase activity
Biological Process GO:0043266 regulation of potassium ion transport
Biological Process GO:0002028 regulation of sodium ion transport
Biological Process GO:0051823 regulation of synapse structural plasticity
Biological Process GO:0032228 regulation of synaptic transmission, GABAergic
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0001975 response to amphetamine
Biological Process GO:0048678 response to axon injury
Biological Process GO:0042220 response to cocaine
Biological Process GO:0042493 response to drug
Biological Process GO:0045471 response to ethanol
Biological Process GO:0034776 response to histamine
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0014854 response to inactivity
Biological Process GO:0010039 response to iron ion
Biological Process GO:0009416 response to light stimulus
Biological Process GO:0043278 response to morphine
Biological Process GO:0035094 response to nicotine
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0007608 sensory perception of smell
Biological Process GO:0001964 startle response
Biological Process GO:0021756 striatum development
Biological Process GO:0007416 synapse assembly
Biological Process GO:0001963 synaptic transmission, dopaminergic
Biological Process GO:0001659 temperature homeostasis
Biological Process GO:0008542 visual learning
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0035240 dopamine binding
molecular function GO:0004952 dopamine neurotransmitter receptor activity
molecular function GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go
molecular function GO:0008144 drug binding
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0042802 identical protein binding
molecular function GO:0035255 ionotropic glutamate receptor binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0005102 signaling receptor binding
cellular component GO:0001669 acrosomal vesicle
cellular component GO:0030424 axon
cellular component GO:0043679 axon terminus
cellular component GO:0060170 ciliary membrane
cellular component GO:0005929 cilium
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0030425 dendrite
cellular component GO:0043197 dendritic spine
cellular component GO:0098691 dopaminergic synapse
cellular component GO:0030139 endocytic vesicle
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0000139 Golgi membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0016328 lateral plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0097730 non-motile cilium
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0036126 sperm flagellum
cellular component GO:0030672 synaptic vesicle membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000284 alpha-Tocopherol 430.71
BXGC0000538 (R)-Norepinephrine 169.18
BXGC0000994 Liriodenine 275.26
BXGC0001495 (R)-Roemerine 279.33
BXGC0001538 Atherosperminine 309.4
BXGC0002867 Lappaurin 284.74
BXGC0003005 3-Phenylpyridine 155.2
BXGC0003066 Phenols 199.27
BXGC0003196 Aripiprazole 448.39
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005683 Quercetin 302.24
BXGC0005867 Serotonin 176.22
BXGC0005871 Dopamine 153.18
BXGC0006162 L-Glutamic acid 147.13
BXGC0006391 Benzene 78.11
BXGC0013854 Histamine 111.08
BXGC0014063 Norstephalagine 295.12
BXGC0014322 (S)-Bulbocapnine 325.13
BXGC0014634 Homoaromoline 608.29
BXGC0014893 2,3-Dimethoxy-6-Methyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinolin-1-Ol 311.15
BXGC0018063 Alprenolol 249.17
BXGC0018547 N,N-Dimethyl-2-Naphtho[2,1-G][1,3]Benzodioxol-5-Ylethanamine 293.14
BXGC0019520 Anolobine 281.11
BXGC0021893 Norepinephrine 169.07
BXGC0022524 Isopiline 297.14
BXGC0024748 Anonaine 265.11
BXGC0026391 Naloxone 327.15
BXGC0030085 Bicuculline 367.11
BXGC0030901 Morphine 285.14
BXGC0031080 Scopolamine 303.15
BXGC0031384 Epinephrine 183.09
BXGC0033674 Predicentrine 341.16
BXGC0034961 Norboldine 313.13
BXGC0035865 (+)-Pentazocine 285.21
BXGC0038837 Pseudohypericin 520.08
BXGC0041195 Boldine 327.15
BXGC0041240 Atenolol 266.16
BXGC0042222 Propranolol 259.16
BXGC0042455 (+/-)-Nuciferine 295.16
BXGC0042510 Fluoxetine 309.13
BXGC0042574 Ibogaine 310.2
BXGC0045489 [(8E,10E,12E,14R)-14-Hydroxyheptadeca-8,10,12-Trien-4,6-Diynyl] Acetate 300.17
BXGC0045812 Trifluoperazine 407.16
BXGC0046755 Yohimbine 354.19
BXGC0048699 Obaberine 622.3
BXGC0050517 (R)-(+)-Coclaurine 285.14
BXGC0050599 tetrandrine 622.3
BXGC0053872 Glaucine 355.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein