Showing entry for Ras-related protein Rap-1b


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011370
Protein NameRas-related protein Rap-1b
Uniport IdP61224
GeneRAP1B
Gene Id5908
DomainRas
Pfam PF00071  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
5. Organismal Systems 5.6 Nervous system hsa04720 Long-term potentiation
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
6. Human Diseases 6.2 Cancers: Specific types hsa05211 Renal cell carcinoma
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0097211 cellular response to gonadotropin-releasing hormone
Biological Process GO:0061028 establishment of endothelial barrier
Biological Process GO:0035722 interleukin-12-mediated signaling pathway
Biological Process GO:0045955 negative regulation of calcium ion-dependent exocytosis
Biological Process GO:2000301 negative regulation of synaptic vesicle exocytosis
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0033625 positive regulation of integrin activation
Biological Process GO:0032486 Rap protein signal transduction
Biological Process GO:1901888 regulation of cell junction assembly
Biological Process GO:2000114 regulation of establishment of cell polarity
Biological Process GO:0009743 response to carbohydrate
molecular function GO:0019003 GDP binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0044877 protein-containing complex binding
cellular component GO:0035577 azurophil granule membrane
cellular component GO:0005911 cell-cell junction
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005622 intracellular
cellular component GO:0005811 lipid droplet
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-354192 Integrin signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-392517 Rap1 signalling
R-HSA-447115 Interleukin-12 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6798695 Neutrophil degranulation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-6806834 Signaling by MET
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875878 MET promotes cell motility
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9020591 Interleukin-12 signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9649948 Signaling downstream of RAS mutants
R-HSA-9656223 Signaling by RAF1 mutants
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0003492 BXGD000198 Aortic coarctation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009363 BXGD000599 Congenital ocular coloboma (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018081 BXGD001171 Gonorrhea Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018816 BXGD001234 Heart Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027126 BXGD001976 Myotonic Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0152421 BXGD003586 Macrotia
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0220620 BXGD004299 Gastrointestinal Carcinoid Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0232466 BXGD004543 Feeding difficulties
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239998 BXGD005012 Recurrent infections Pathological Conditions, Signs and Symptoms; Infections; Musculoskeletal Diseases
C0240340 BXGD005031 Microdontia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0265677 BXGD005564 Congenital hemivertebra Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266544 BXGD005691 Microcornea Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0272138 BXGD006308 Erythroblastosis
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0341059 BXGD007388 Lip pit
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0424448 BXGD008529 Mask-like facies Nervous System Diseases
C0432333 BXGD008778 Abnormal dermatoglyphic pattern Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0521619 BXGD009149 Obstruction of pelviureteric junction Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0542514 BXGD009277 Blue sclera Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0575802 BXGD009521 Small hand
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0796004 BXGD010776 Kabuki make-up syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases; Hemic and Lymphatic Diseases
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1336708 BXGD012852 Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1835796 BXGD014048 Crossed fused renal ectopia
C1835801 BXGD014050 Eversion of lateral third of lower eyelids Eye Diseases
C1842180 BXGD014504 CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C1842878 BXGD014543 Short 5th finger
C1844752 BXGD014672 Butterfly vertebrae
C1844813 BXGD014679 Widely spaced teeth
C1846950 BXGD014848 Short middle phalanx of finger
C1853738 BXGD015357 Long eyelashes
C1855285 BXGD015483 Protruding ear
C1857206 BXGD015684 Sparse lateral eyebrow
C1857453 BXGD015703 Renal hypoplasia/aplasia
C1857479 BXGD015705 Short columella
C1858565 BXGD015807 Duplicated collecting system
C1860816 BXGD016001 Preauricular skin tag
C1864040 BXGD016210 Cerebral Cavernous Malformations 3 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Stomatognathic Diseases; Behavior and Behavior Mechanisms
C1868571 BXGD016508 Highly arched eyebrow
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2919142 BXGD017867 Short Stature, CTCAE
C2919945 BXGD017882 Cavernous Hemangioma of Brain Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C2931367 BXGD018010 Thyroid cancer, follicular Neoplasms
C3278923 BXGD018748 Dilated ventricles (finding)
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3553764 BXGD019187 Joint hyperflexibility
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3888194 BXGD019955 MIXED LINEAGE LEUKEMIA
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4551583 BXGD023361 Cerebral cortical atrophy
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721779 BXGD023769 Ovarian cancer stage IV
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein