Showing entry for Heterogeneous nuclear ribonucleoprotein K


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011399
Protein NameHeterogeneous nuclear ribonucleoprotein K
Uniport IdP61978
GeneHNRNPK
Gene Id3190
DomainKH_1; ROKNT
Pfam PF00013   PF08067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.1 Transcription hsa03040 Spliceosome
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0048025 negative regulation of mRNA splicing, via spliceosome
Biological Process GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process
Biological Process GO:0048260 positive regulation of receptor-mediated endocytosis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process GO:0010988 regulation of low-density lipoprotein particle clearance
Biological Process GO:0048024 regulation of mRNA splicing, via spliceosome
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0016070 RNA metabolic process
Biological Process GO:0006396 RNA processing
Biological Process GO:0007165 signal transduction
Biological Process GO:0016032 viral process
molecular function GO:0045296 cadherin binding
molecular function GO:0003677 DNA binding
molecular function GO:0042802 identical protein binding
molecular function GO:0003729 mRNA binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0003723 RNA binding
cellular component GO:0071013 catalytic step 2 spliceosome
cellular component GO:0042995 cell projection
cellular component GO:0005737 cytoplasm
cellular component GO:0010494 cytoplasmic stress granule
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0016020 membrane
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0002102 podosome
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-392499 Metabolism of proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854 Metabolism of RNA
R-HSA-9609646 HCMV Infection
R-HSA-9610379 HCMV Late Events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005699 BXGD000325 Blast Phase Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006157 BXGD000377 Breech Presentation Female Urogenital Diseases and Pregnancy Complications
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0016522 BXGD001067 Foramen Ovale, Patent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018939 BXGD001253 Hematological Disease Hemic and Lymphatic Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020555 BXGD001431 Hypertrichosis Skin and Connective Tissue Diseases
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026948 BXGD001952 Mycosis Fungoides Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0032019 BXGD002321 Pituitary Neoplasms Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152421 BXGD003586 Macrotia
C0152423 BXGD003587 Congenital small ears Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0152427 BXGD003590 Polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205748 BXGD004117 Dysplastic Nevus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220697 BXGD004324 POLYDACTYLY, POSTAXIAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221217 BXGD004408 Neck webbing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0221356 BXGD004448 Brachycephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221358 BXGD004450 Long narrow head
C0232466 BXGD004543 Feeding difficulties
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0235991 BXGD004802 Small for gestational age (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0239234 BXGD004974 Low set ears
C0240379 BXGD005033 Open mouth (finding)
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265610 BXGD005555 Clinodactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266030 BXGD005609 Supernumerary mesiodens tooth Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0266449 BXGD005670 Congenital anomaly of brain Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases
C0269269 BXGD006058 Inversion of nipple (disorder) Skin and Connective Tissue Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0332615 BXGD006898 Myopathic facies
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346429 BXGD007828 Multiple malignancy Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423110 BXGD008471 Downward slant of palpebral fissure
C0426209 BXGD008556 amniotic fluid meconium stained
C0426816 BXGD008584 Absence of rib
C0426848 BXGD008590 Sacral dimple Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0431378 BXGD008679 Nodular heterotopia Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0432123 BXGD008724 Sagittal craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0432215 BXGD008739 Progressive pseudorheumatoid dysplasia Musculoskeletal Diseases
C0549629 BXGD009393 Abnormal delivery
C0557874 BXGD009444 Global developmental delay
C0575158 BXGD009515 Kyphoscoliosis deformity of spine Musculoskeletal Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0685707 BXGD009814 Muscular ventricular septum defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0743360 BXGD010082 Recurrent ear infections
C0746889 BXGD010154 Hyperpigmented nevi Neoplasms
C0796004 BXGD010776 Kabuki make-up syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases; Hemic and Lymphatic Diseases
C0920299 BXGD011465 Overriding toe Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328407 BXGD012465 Hip Dysplasia Musculoskeletal Diseases; Wounds and Injuries
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1386048 BXGD012950 Intrauterine retardation
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1608408 BXGD013434 Malignant transformation
C1827524 BXGD013773 Wide spaced nipples
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1834055 BXGD013953 Underdeveloped nasal alae
C1835807 BXGD014051 Prominent fingertip pads
C1836047 BXGD014074 Long face
C1836940 BXGD014182 Thickened nuchal skin fold
C1842364 BXGD014511 Central hypotonia
C1843367 BXGD014576 Poor school performance
C1844820 BXGD014681 Range of joint movement increased
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1849025 BXGD014997 Oval face
C1849340 BXGD015039 Long palpebral fissure
C1849367 BXGD015046 Nasal bridge wide
C1849735 BXGD015082 Underfolded helix
C1851897 BXGD015245 Anterior creases of earlobe
C1853638 BXGD015349 Broad neck
C1854928 BXGD015443 Protuberant abdomen
C1855285 BXGD015483 Protruding ear
C1855728 BXGD015536 Low posterior hairline
C1857206 BXGD015684 Sparse lateral eyebrow
C1857539 BXGD015716 Deep palmar crease
C1857953 BXGD015759 Deep plantar creases
C1858043 BXGD015765 Hydronephrosis, Congenital, with Cleft Palate, Characteristic Facies, Hypotonia, and Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Nervous System Diseases; Mental Disorders; Stomatognathic Diseases; Behavior and Behavior Mechanisms
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859236 BXGD015867 Prolonged neonatal jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1859717 BXGD015924 Depressed nasal tip
C1860834 BXGD016006 Infantile muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861324 BXGD016029 Short philtrum
C1861866 BXGD016087 Aplasia/Hypoplasia of the corpus callosum
C1865244 BXGD016301 Shallow orbits Eye Diseases
C1865572 BXGD016331 Proximal placement of thumb
C1866195 BXGD016385 Downturned corners of mouth
C1868571 BXGD016508 Highly arched eyebrow
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2267233 BXGD017017 Neonatal Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2673410 BXGD017200 Small midface
C2674608 BXGD017250 Feeding difficulties in infancy
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3693299 BXGD019336 Broad uvula
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3807980 BXGD019534 Apneic episodes in infancy Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C3839868 BXGD019788 Cytogenetically normal acute myeloid leukemia Neoplasms
C4020699 BXGD020469 Congenital dermal melanocytosis
C4020718 BXGD020472 Wide nasal ridge
C4021194 BXGD020577 Underdeveloped inferior crus of antihelix
C4021824 BXGD020809 Postaxial polysyndactyly of foot
C4023523 BXGD021210 Bilateral fetal pyelectasis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C4082304 BXGD022090 Oligodontia
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4225274 BXGD022205 AU-KLINE SYNDROME
C4551563 BXGD023351 Microcephaly (physical finding)
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002953 2-Phenethyl isothiocyanate 163.24
BXGC0051100 dihydroartemisinin 284.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein