Showing entry for 14-3-3 protein gamma


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011400
Protein Name14-3-3 protein gamma
Uniport IdP61981
GeneYWHAG
Gene Id7532
Domain41701
Pfam PF00244  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04110 Cell cycle
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0097711 ciliary basal body-plasma membrane docking
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0061024 membrane organization
Biological Process GO:0006469 negative regulation of protein kinase activity
Biological Process GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Biological Process GO:0006605 protein targeting
Biological Process GO:0010389 regulation of G2/M transition of mitotic cell cycle
Biological Process GO:0045664 regulation of neuron differentiation
Biological Process GO:0009966 regulation of signal transduction
Biological Process GO:0048167 regulation of synaptic plasticity
molecular function GO:0042802 identical protein binding
molecular function GO:0005159 insulin-like growth factor receptor binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0005080 protein kinase C binding
molecular function GO:0008426 protein kinase C inhibitor activity
molecular function GO:0030971 receptor tyrosine kinase binding
molecular function GO:0003723 RNA binding
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0098793 presynapse
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-109606 Intrinsic Pathway for Apoptosis
R-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-114452 Activation of BH3-only proteins
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-162582 Signal Transduction
R-HSA-1640170 Cell Cycle
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-199991 Membrane Trafficking
R-HSA-212436 Generic Transcription Pathway
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380287 Centrosome maturation
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-5357801 Programmed Cell Death
R-HSA-5617833 Cilium Assembly
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5653656 Vesicle-mediated transport
R-HSA-68877 Mitotic Prometaphase
R-HSA-68886 M Phase
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-9614085 FOXO-mediated transcription
R-HSA-9614399 Regulation of localization of FOXO transcription factors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028756 BXGD002083 Obesity, Morbid Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239676 BXGD004989 High forehead
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0349588 BXGD007933 Short stature
C0423110 BXGD008471 Downward slant of palpebral fissure
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0563243 BXGD009479 Poor coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0815123 BXGD010863 neurobehavioral problems
C0856863 BXGD011122 Broad-based gait
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1834433 BXGD013973 Obsessive-compulsive trait Behavior and Behavior Mechanisms
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1842581 BXGD014525 Abnormal corpus callosum morphology Pathological Conditions, Signs and Symptoms
C1857704 BXGD015741 Abnormal myelination
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2919142 BXGD017867 Short Stature, CTCAE
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4023687 BXGD021243 EEG with multifocal slow activity
C4025846 BXGD021826 Abnormality of vision
C4540034 BXGD023238 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 56
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0002722 Nitrate 62
BXGC0005682 3,3',4,4'-Tetrahydroxylignan 302.36
BXGC0034783 Doxorubicin 543.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein