Showing entry for Actin, aortic smooth muscle


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011452
Protein NameActin, aortic smooth muscle
Uniport IdP62736
GeneACTA2
Gene Id59
DomainActin
Pfam PF00022  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04926 Relaxin signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0072144 glomerular mesangial cell development
Biological Process GO:0090131 mesenchyme migration
Biological Process GO:0006936 muscle contraction
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0009615 response to virus
Biological Process GO:0014829 vascular associated smooth muscle contraction
molecular function GO:0005524 ATP binding
molecular function GO:0019901 protein kinase binding
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0044297 cell body
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005869 dynactin complex
cellular component GO:0070062 extracellular exosome
cellular component GO:0005615 extracellular space
cellular component GO:0030175 filopodium
cellular component GO:0030027 lamellipodium
cellular component GO:0032991 protein-containing complex
cellular component GO:0030485 smooth muscle contractile fiber
Reactome
Pathway Id Pathway Name
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-397014 Muscle contraction
R-HSA-445355 Smooth Muscle Contraction
R-HSA-9013694 Signaling by NOTCH4
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0002949 BXGD000157 Aneurysm, Dissecting Cardiovascular Diseases
C0003486 BXGD000197 Aortic Aneurysm Cardiovascular Diseases
C0003493 BXGD000199 Aortic Diseases Cardiovascular Diseases
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0003706 BXGD000215 Arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005398 BXGD000311 Cholestasis, Extrahepatic Digestive System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009782 BXGD000631 Connective Tissue Diseases Skin and Connective Tissue Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0012736 BXGD000785 Dissecting aortic aneurysm Cardiovascular Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013405 BXGD000834 Dyspnea, Paroxysmal Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Cardiovascular Diseases
C0013720 BXGD000861 Ehlers-Danlos Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016052 BXGD001040 Fibromuscular Dysplasia Cardiovascular Diseases
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017668 BXGD001143 Focal glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018816 BXGD001234 Heart Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019079 BXGD001278 Hemoptysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0019189 BXGD001298 Hepatitis, Chronic Digestive System Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0022116 BXGD001531 Ischemia Pathological Conditions, Signs and Symptoms
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024796 BXGD001806 Marfan Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0026961 BXGD001953 Mydriasis Eye Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027719 BXGD002027 Nephrosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032326 BXGD002351 Pneumothorax Respiratory Tract Diseases
C0033770 BXGD002417 Prune Belly Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037285 BXGD002680 Skin Manifestations Pathological Conditions, Signs and Symptoms
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0039446 BXGD002811 Telangiectasis Cardiovascular Diseases
C0040021 BXGD002834 Thromboangiitis Obliterans Cardiovascular Diseases
C0041956 BXGD002942 Ureteral obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0085436 BXGD003177 Meningitis, Cryptococcal Infections; Nervous System Diseases
C0086432 BXGD003281 Hyalinosis, Segmental Glomerular Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0086565 BXGD003295 Liver Dysfunction Digestive System Diseases
C0149519 BXGD003326 Chronic Persistent Hepatitis Digestive System Diseases
C0149630 BXGD003334 Bicuspid aortic valve Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0158638 BXGD003896 Congenital anomaly of cerebrovascular system Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0160390 BXGD003921 Injury of liver Digestive System Diseases; Wounds and Injuries
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0162872 BXGD003997 Aortic Aneurysm, Thoracic Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206157 BXGD004165 Myopathies, Nemaline Musculoskeletal Diseases; Nervous System Diseases
C0221210 BXGD004406 Congenital malrotation of intestine Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0231807 BXGD004524 Dyspnea on exertion Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0231835 BXGD004527 Tachypnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0232474 BXGD004544 Increased peristalsis
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0241240 BXGD005089 Tall stature
C0241868 BXGD005118 acute aortic dissection Cardiovascular Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242698 BXGD005189 Ventricular Dysfunction, Left Cardiovascular Diseases
C0263401 BXGD005298 Cutis marmorata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases; Cardiovascular Diseases; Wounds and Injuries
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0281967 BXGD006792 Retinal infarction
C0340629 BXGD007354 Aortic aneurysm without mention of rupture NOS Cardiovascular Diseases
C0340630 BXGD007355 Aortic Aneurysm, Thoracoabdominal Cardiovascular Diseases
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345050 BXGD007717 Congenital aneurysm of ascending aorta Cardiovascular Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0392775 BXGD008067 Cystic medial necrosis of aorta Pathological Conditions, Signs and Symptoms; Neoplasms; Cardiovascular Diseases
C0403647 BXGD008301 Hypotonic bladder disorder Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0431401 BXGD008685 Gillespie syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0520463 BXGD009085 Chronic active hepatitis Digestive System Diseases
C0524611 BXGD009235 Cryptogenic Chronic Hepatitis Digestive System Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0546884 BXGD009345 Hypovolemia Pathological Conditions, Signs and Symptoms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0741621 BXGD010038 Brachial artery occlusion
C0750145 BXGD010227 Occlusive vascular disease
C0852949 BXGD010957 Arteriopathic disease Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0855095 BXGD011071 Small Lymphocytic Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0856747 BXGD011112 Aneurysm of ascending aorta Respiratory Tract Diseases; Cardiovascular Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0949658 BXGD011582 Cardiomyopathy, Hypertrophic, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1298820 BXGD012252 Aneurysm of aortic root Cardiovascular Diseases
C1299567 BXGD012260 Neonatal stroke Nervous System Diseases; Cardiovascular Diseases
C1303010 BXGD012321 Mydriasis, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332965 BXGD012565 Congenital Mesoblastic Nephroma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1388233 BXGD012961 Aneurysm of descending thoracic aorta Cardiovascular Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1611743 BXGD013456 Familial (FPAH)
C1619692 BXGD013458 Nephrogenic Fibrosing Dermopathy Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1836653 BXGD014143 Ascending aortic dissection Cardiovascular Diseases
C1837404 BXGD014229 High, narrow palate
C1846837 BXGD014842 Aortic Aneurysm, Familial Thoracic 2 Cardiovascular Diseases
C1851712 BXGD015227 Dural ectasia
C1860493 BXGD015987 Abnormality of the sternum
C1876165 BXGD016556 Copper-Overload Cirrhosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2004461 BXGD016872 Bowel dysfunction Digestive System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2673186 BXGD017185 Aortic Aneurysm, Familial Thoracic 6 Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C2674950 BXGD017262 LUNG CANCER, SUSCEPTIBILITY TO
C2931117 BXGD017960 Fetal megacystis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2945695 BXGD018187 Limb ischemia
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3151201 BXGD018405 MULTISYSTEMIC SMOOTH MUSCLE DYSFUNCTION SYNDROME
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3279690 BXGD018771 MOYAMOYA DISEASE 5
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C3495549 BXGD018991 Patent ductus arteriosus - persisting type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Cardiovascular Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3888391 BXGD019969 Nonnuclear polymorphic congenital cataract
C3888570 BXGD019981 Degenerative mitral valve disease
C4022001 BXGD020863 Abnormality of the cerebral vasculature
C4022878 BXGD021026 Descending aortic dissection Cardiovascular Diseases
C4023169 BXGD021133 Moyamoya phenomenon
C4025272 BXGD021615 Peripheral arterial stenosis
C4025690 BXGD021734 Prenatal maternal abnormality
C4025845 BXGD021825 Abnormality iris morphology
C4082974 BXGD022099 Dupuytren's Disease Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C4289994 BXGD022505 Adenosine Deaminase 2 Deficiency Skin and Connective Tissue Diseases; Cardiovascular Diseases
C4293686 BXGD022512 Periventricular white matter hyperdensities
C4476540 BXGD022824 Dilatation of the cerebral artery Nervous System Diseases; Cardiovascular Diseases
C4476554 BXGD022829 Carotid artery dilatation
C4477072 BXGD022916 Iris flocculi
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4707243 BXGD023712 Familial thoracic aortic aneurysm and aortic dissection
C4721507 BXGD023747 Alveolitis, Fibrosing Respiratory Tract Diseases
C4732796 BXGD023903 Apical hypertrophic cardiomyopathy Cardiovascular Diseases
C4744444 BXGD023941 Metastatic Lung Adenocarcinoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002953 2-Phenethyl isothiocyanate 163.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein