Showing entry for Ubiquitin-conjugating enzyme E2 D2



                       
General Target Information
BXGT IdBXGT011465
Protein NameUbiquitin-conjugating enzyme E2 D2
Uniport IdP62837
GeneUBE2D2
Gene Id7322
DomainUQ_con
Pfam PF00179  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05131 Shigellosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006464 cellular protein modification process
Biological Process GO:0002756 MyD88-independent toll-like receptor signaling pathway
Biological Process GO:0051865 protein autoubiquitination
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006625 protein targeting to peroxisome
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0035666 TRIF-dependent toll-like receptor signaling pathway
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0005524 ATP binding
molecular function GO:0061631 ubiquitin conjugating enzyme activity
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0000151 ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1234174 Cellular response to hypoxia
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1280218 Adaptive Immune System
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-2262752 Cellular responses to stress
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-392499 Metabolism of proteins
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-597592 Post-translational protein modification
R-HSA-8852135 Protein ubiquitination
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-8951664 Neddylation
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9033241 Peroxisomal protein import
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-9609507 Protein localization
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751967 BXGD010657 Multiple Sclerosis, Relapsing-Remitting Immune System Diseases; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C2699541 BXGD017461 Cytokine Measurement
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002591 Potassium 39.1
BXGC0002722 Nitrate 62
BXGC0003705 Chloride 35.45
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein