Showing entry for Peptidyl-prolyl cis-trans isomerase FKBP1A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011474
Protein NamePeptidyl-prolyl cis-trans isomerase FKBP1A
Uniport IdP62942
GeneFKBP1A
Gene Id2280
DomainFKBP_C
Pfam PF00254  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006458 'de novo' protein folding
Biological Process GO:1990000 amyloid fibril formation
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0061077 chaperone-mediated protein folding
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0060347 heart trabecula formation
Biological Process GO:0032515 negative regulation of phosphoprotein phosphatase activity
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0031398 positive regulation of protein ubiquitination
Biological Process GO:0006457 protein folding
Biological Process GO:0022417 protein maturation by protein folding
Biological Process GO:0000413 protein peptidyl-prolyl isomerization
Biological Process GO:0042026 protein refolding
Biological Process GO:0032925 regulation of activin receptor signaling pathway
Biological Process GO:1902991 regulation of amyloid precursor protein catabolic process
Biological Process GO:0050776 regulation of immune response
Biological Process GO:0032880 regulation of protein localization
Biological Process GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:0007183 SMAD protein complex assembly
Biological Process GO:0097435 supramolecular fiber organization
Biological Process GO:0042110 T cell activation
Biological Process GO:0055010 ventricular cardiac muscle tissue morphogenesis
molecular function GO:0048185 activin binding
molecular function GO:0005528 FK506 binding
molecular function GO:0044325 ion channel binding
molecular function GO:0005527 macrolide binding
molecular function GO:0003755 peptidyl-prolyl cis-trans isomerase activity
molecular function GO:0046332 SMAD binding
molecular function GO:0005160 transforming growth factor beta receptor binding
molecular function GO:0034713 type I transforming growth factor beta receptor binding
cellular component GO:0005737 cytoplasm
cellular component GO:0098562 cytoplasmic side of membrane
cellular component GO:0005829 cytosol
cellular component GO:0031312 extrinsic component of organelle membrane
cellular component GO:0016020 membrane
cellular component GO:1990425 ryanodine receptor complex
cellular component GO:0016529 sarcoplasmic reticulum
cellular component GO:0014802 terminal cisterna
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-165159 MTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-2025928 Calcineurin activates NFAT
R-HSA-2025928 Calcineurin activates NFAT
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer
R-HSA-3656534 Loss of Function of TGFBR1 in Cancer
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663205 Infectious disease
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000833 BXGD000014 Abscess Pathological Conditions, Signs and Symptoms; Infections
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0016037 BXGD001035 Fibrodysplasia Ossificans Progressiva Musculoskeletal Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032131 BXGD002330 Plasmacytoma Neoplasms; Immune System Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038354 BXGD002746 Stomach Diseases Digestive System Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0235889 BXGD004784 Arthritis aggravated Musculoskeletal Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242966 BXGD005201 Systemic Inflammatory Response Syndrome Pathological Conditions, Signs and Symptoms
C0268800 BXGD006041 Simple renal cyst Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0270952 BXGD006139 Muscular Dystrophy, Oculopharyngeal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0574083 BXGD009501 3-Methylglutaconic aciduria type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Cardiovascular Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751951 BXGD010648 Central Core Myopathy (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C2986658 BXGD018234 Diffuse Intrinsic Pontine Glioma
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002144 Tetradecanoic acid 228.37
BXGC0003705 Chloride 35.45
BXGC0033776 Cycloheximide 281.16
BXGC0036712 4-hydroxy-2-butanone 88.05
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein