protein

Showing entry for High mobility group protein B1

General Target Information
BXGT Id	BXGT011505
Protein Name	High mobility group protein B1
Uniport Id	P63158
Gene	Hmgb1
Gene Id	15289
Domain	HMG_box; HMG_box_2
Pfam	PF00505 PF09011
Organism	Mus musculus (Mouse)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0002218	activation of innate immune response
Biological Process	GO:0043277	apoptotic cell clearance
Biological Process	GO:0006914	autophagy
Biological Process	GO:0006284	base-excision repair
Biological Process	GO:0060326	cell chemotaxis
Biological Process	GO:0098761	cellular response to interleukin-7
Biological Process	GO:0071222	cellular response to lipopolysaccharide
Biological Process	GO:0031497	chromatin assembly
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006342	chromatin silencing
Biological Process	GO:0032502	developmental process
Biological Process	GO:0032392	DNA geometric change
Biological Process	GO:0006310	DNA recombination
Biological Process	GO:0035767	endothelial cell chemotaxis
Biological Process	GO:0001935	endothelial cell proliferation
Biological Process	GO:0001654	eye development
Biological Process	GO:0050930	induction of positive chemotaxis
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0002437	inflammatory response to antigenic stimulus
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0030324	lung development
Biological Process	GO:0002281	macrophage activation involved in immune response
Biological Process	GO:0001773	myeloid dendritic cell activation
Biological Process	GO:2000426	negative regulation of apoptotic cell clearance
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration
Biological Process	GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation
Biological Process	GO:0032689	negative regulation of interferon-gamma production
Biological Process	GO:0017055	negative regulation of RNA polymerase II transcription preinitiation complex assembly
Biological Process	GO:0097350	neutrophil clearance
Biological Process	GO:0002270	plasmacytoid dendritic cell activation
Biological Process	GO:0042104	positive regulation of activated T cell proliferation
Biological Process	GO:0010508	positive regulation of autophagy
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration
Biological Process	GO:2001200	positive regulation of dendritic cell differentiation
Biological Process	GO:0043388	positive regulation of DNA binding
Biological Process	GO:0051106	positive regulation of DNA ligation
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0045819	positive regulation of glycogen catabolic process
Biological Process	GO:0045089	positive regulation of innate immune response
Biological Process	GO:0032727	positive regulation of interferon-alpha production
Biological Process	GO:0032728	positive regulation of interferon-beta production
Biological Process	GO:0032733	positive regulation of interleukin-10 production
Biological Process	GO:0032735	positive regulation of interleukin-12 production
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production
Biological Process	GO:0032732	positive regulation of interleukin-1 production
Biological Process	GO:0032755	positive regulation of interleukin-6 production
Biological Process	GO:0032757	positive regulation of interleukin-8 production
Biological Process	GO:0046330	positive regulation of JNK cascade
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation
Biological Process	GO:0032425	positive regulation of mismatch repair
Biological Process	GO:0045931	positive regulation of mitotic cell cycle
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling
Biological Process	GO:0001934	positive regulation of protein phosphorylation
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis
Biological Process	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation
Biological Process	GO:0090303	positive regulation of wound healing
Biological Process	GO:2000819	regulation of nucleotide-excision repair
Biological Process	GO:0032072	regulation of restriction endodeoxyribonuclease activity
Biological Process	GO:0010469	regulation of signaling receptor activity
Biological Process	GO:0002840	regulation of T cell mediated immune response to tumor cell
Biological Process	GO:0002643	regulation of tolerance induction
Biological Process	GO:0006355	regulation of transcription, DNA-templated
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0051384	response to glucocorticoid
Biological Process	GO:0035711	T-helper 1 cell activation
Biological Process	GO:0045063	T-helper 1 cell differentiation
Biological Process	GO:1990774	tumor necrosis factor secretion
Biological Process	GO:0033151	V(D)J recombination
molecular function	GO:0003681	bent DNA binding
molecular function	GO:0000405	bubble DNA binding
molecular function	GO:0010858	calcium-dependent protein kinase regulator activity
molecular function	GO:0003682	chromatin binding
molecular function	GO:0000402	crossed form four-way junction DNA binding
molecular function	GO:0019958	C-X-C chemokine binding
molecular function	GO:0005125	cytokine activity
molecular function	GO:0003684	damaged DNA binding
molecular function	GO:0008301	DNA binding, bending
molecular function	GO:0070182	DNA polymerase binding
molecular function	GO:0003690	double-stranded DNA binding
molecular function	GO:0003725	double-stranded RNA binding
molecular function	GO:0000400	four-way junction DNA binding
molecular function	GO:0008201	heparin binding
molecular function	GO:0005178	integrin binding
molecular function	GO:0001530	lipopolysaccharide binding
molecular function	GO:0016829	lyase activity
molecular function	GO:0000401	open form four-way junction DNA binding
molecular function	GO:0001786	phosphatidylserine binding
molecular function	GO:0030295	protein kinase activator activity
molecular function	GO:0070491	repressing transcription factor binding
molecular function	GO:0003727	single-stranded RNA binding
molecular function	GO:0097100	supercoiled DNA binding
molecular function	GO:0003713	transcription coactivator activity
molecular function	GO:0008134	transcription factor binding
molecular function	GO:0000976	transcription regulatory region sequence-specific DNA binding
cellular component	GO:0035868	alphav-beta3 integrin-HMGB1 complex
cellular component	GO:0009986	cell surface
cellular component	GO:0000793	condensed chromosome
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005769	early endosome
cellular component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
cellular component	GO:0005576	extracellular region
cellular component	GO:0005615	extracellular space
cellular component	GO:0043005	neuron projection
cellular component	GO:0000790	nuclear chromatin
cellular component	GO:0005634	nucleus
cellular component	GO:0017053	transcription repressor complex

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0026595	Glycyrrhizin		822.4

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}