Showing entry for Peptidyl-prolyl cis-trans isomerase FKBP1B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011576
Protein NamePeptidyl-prolyl cis-trans isomerase FKBP1B
Uniport IdP68106
GeneFKBP1B
Gene Id2281
DomainFKBP_C
Pfam PF00254  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006458 'de novo' protein folding
Biological Process GO:0035584 calcium-mediated signaling using intracellular calcium source
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0061077 chaperone-mediated protein folding
Biological Process GO:0030073 insulin secretion
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0010459 negative regulation of heart rate
Biological Process GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0032515 negative regulation of phosphoprotein phosphatase activity
Biological Process GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
Biological Process GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:0019227 neuronal action potential propagation
Biological Process GO:0048680 positive regulation of axon regeneration
Biological Process GO:0051284 positive regulation of sequestering of calcium ion
Biological Process GO:0022417 protein maturation by protein folding
Biological Process GO:0000413 protein peptidyl-prolyl isomerization
Biological Process GO:0042026 protein refolding
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0051480 regulation of cytosolic calcium ion concentration
Biological Process GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0009749 response to glucose
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0051775 response to redox state
Biological Process GO:0033197 response to vitamin E
Biological Process GO:0006939 smooth muscle contraction
Biological Process GO:0042098 T cell proliferation
molecular function GO:0019855 calcium channel inhibitor activity
molecular function GO:0030551 cyclic nucleotide binding
molecular function GO:0005528 FK506 binding
molecular function GO:0044325 ion channel binding
molecular function GO:0003755 peptidyl-prolyl cis-trans isomerase activity
molecular function GO:0005102 signaling receptor binding
cellular component GO:0034704 calcium channel complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
cellular component GO:0033017 sarcoplasmic reticulum membrane
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000833 BXGD000014 Abscess Pathological Conditions, Signs and Symptoms; Infections
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0038354 BXGD002746 Stomach Diseases Digestive System Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0235889 BXGD004784 Arthritis aggravated Musculoskeletal Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1631597 BXGD013480 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0004188 Propanedioic acid 104.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein