Showing entry for DNA-dependent protein kinase catalytic subunit


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011846
Protein NameDNA-dependent protein kinase catalytic subunit
Uniport IdP78527
GenePRKDC
Gene Id5591
DomainFAT; FATC; NUC194; PI3_PI4_kinase
Pfam PF02259   PF02260   PF08163   PF00454  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03450 Non-homologous end-joining
4. Cellular Processes 4.2 Cell growth and death hsa04110 Cell cycle
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002218 activation of innate immune response
Biological Process GO:0002326 B cell lineage commitment
Biological Process GO:0007420 brain development
Biological Process GO:0006464 cellular protein modification process
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0097681 double-strand break repair via alternative nonhomologous end joining
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0035234 ectopic germ cell programmed cell death
Biological Process GO:0007507 heart development
Biological Process GO:0033152 immunoglobulin V(D)J recombination
Biological Process GO:0045087 innate immune response
Biological Process GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
Biological Process GO:0000460 maturation of 5.8S rRNA
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:2000773 negative regulation of cellular senescence
Biological Process GO:0002638 negative regulation of immunoglobulin production
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:2001229 negative regulation of response to gamma radiation
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0048639 positive regulation of developmental growth
Biological Process GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
Biological Process GO:0045648 positive regulation of erythrocyte differentiation
Biological Process GO:0048146 positive regulation of fibroblast proliferation
Biological Process GO:0045621 positive regulation of lymphocyte differentiation
Biological Process GO:1905221 positive regulation of platelet formation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0032481 positive regulation of type I interferon production
Biological Process GO:0002328 pro-B cell differentiation
Biological Process GO:0031648 protein destabilization
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0042752 regulation of circadian rhythm
Biological Process GO:0050678 regulation of epithelial cell proliferation
Biological Process GO:1902036 regulation of hematopoietic stem cell differentiation
Biological Process GO:0048660 regulation of smooth muscle cell proliferation
Biological Process GO:0014823 response to activity
Biological Process GO:0010332 response to gamma radiation
Biological Process GO:0048511 rhythmic process
Biological Process GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint
Biological Process GO:0034462 small-subunit processome assembly
Biological Process GO:0001756 somitogenesis
Biological Process GO:0048536 spleen development
Biological Process GO:0033077 T cell differentiation in thymus
Biological Process GO:0002360 T cell lineage commitment
Biological Process GO:0033153 T cell receptor V(D)J recombination
Biological Process GO:0016233 telomere capping
Biological Process GO:0000723 telomere maintenance
Biological Process GO:0048538 thymus development
molecular function GO:0005524 ATP binding
molecular function GO:0004677 DNA-dependent protein kinase activity
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0019899 enzyme binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0003723 RNA binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0034511 U3 snoRNA binding
cellular component GO:0005829 cytosol
cellular component GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex
cellular component GO:0016020 membrane
cellular component GO:0070419 nonhomologous end joining complex
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0032993 protein-DNA complex
cellular component GO:0032040 small-subunit processome
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-1834941 STING mediated induction of host immune responses
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-3270619 IRF3-mediated induction of type I IFN
R-HSA-392499 Metabolism of proteins
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-597592 Post-translational protein modification
R-HSA-73894 DNA Repair
R-HSA-8852135 Protein ubiquitination
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001364 BXGD000047 Massive Hepatic Necrosis Digestive System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019147 BXGD001289 Hepatic Coma Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0021603 BXGD001507 Sleep Initiation and Maintenance Disorders Nervous System Diseases; Mental Disorders
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023531 BXGD001684 Leukoplakia Pathological Conditions, Signs and Symptoms; Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0043346 BXGD003043 Xeroderma Pigmentosum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153382 BXGD003627 Malignant neoplasm of oropharynx Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0206656 BXGD004219 Embryonal Rhabdomyosarcoma Neoplasms
C0220613 BXGD004297 Adult Soft Tissue Sarcoma
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0220645 BXGD004307 Childhood Soft Tissue Sarcoma
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398686 BXGD008215 Primary immune deficiency disorder Immune System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0451693 BXGD008823 Severe combined immunodeficiency with low T- and B-cell numbers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0558355 BXGD009452 Tonsillar Carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751197 BXGD010345 Fulminant Hepatic Failure with Cerebral Edema Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751198 BXGD010346 Hepatic Stupor Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948750 BXGD011551 Salivary gland carcinoma Neoplasms; Stomatognathic Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1261473 BXGD011855 Sarcoma Neoplasms
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1275122 BXGD012060 Familial multiple trichoepitheliomata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1832322 BXGD013826 Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, NK Cell-Positive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C1865370 BXGD016320 Severe combined immunodeficiency with sensitivity to ionizing radiation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2349952 BXGD017065 Oropharyngeal Carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3163798 BXGD018516 Recurrent lower respiratory tract infection
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3714514 BXGD019409 Infection Infections
C3898127 BXGD020061 Non-Metastatic Childhood Soft Tissue Sarcoma
C4014833 BXGD020168 IMMUNODEFICIENCY 26 WITH OR WITHOUT NEUROLOGIC ABNORMALITIES
C4016698 BXGD020362 IMMUNODEFICIENCY 26 WITHOUT NEUROLOGIC ABNORMALITIES
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4551687 BXGD023392 Sarcoma of soft tissue Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722419 BXGD023802 Extrapulmonary Small Cell Carcinoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000497 Vanillin 152.15
BXGC0001502 Caffeine 194.19
BXGC0003776 Flavones 222.24
BXGC0024217 Schisandrin B 400.19
BXGC0038991 Selenomethionine 197
BXGC0045812 Trifluoperazine 407.16
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein