protein

Showing entry for Corticosteroid 11-beta-dehydrogenase isozyme 2

General Target Information
BXGT Id	BXGT011895
Protein Name	Corticosteroid 11-beta-dehydrogenase isozyme 2
Uniport Id	P80365
Gene	HSD11B2
Gene Id	3291
Domain	adh_short
Pfam	PF00106
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.3 Lipid metabolism	hsa00140	Steroid hormone biosynthesis
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways
5. Organismal Systems	5.5 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0007565	female pregnancy
Biological Process	GO:0006704	glucocorticoid biosynthetic process
Biological Process	GO:0002017	regulation of blood volume by renal aldosterone
Biological Process	GO:0042493	response to drug
Biological Process	GO:0032094	response to food
Biological Process	GO:0051384	response to glucocorticoid
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0032868	response to insulin
molecular function	GO:0051287	NAD binding
molecular function	GO:0005496	steroid binding
cellular component	GO:0005789	endoplasmic reticulum membrane
molecular function	GO:0003845	11-beta-hydroxysteroid dehydrogenase NAD(P) activity

Reactome

Pathway Id	Pathway Name
R-HSA-1430728	Metabolism
R-HSA-194002	Glucocorticoid biosynthesis
R-HSA-196071	Metabolism of steroid hormones
R-HSA-556833	Metabolism of lipids
R-HSA-8957322	Metabolism of steroids

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001231	BXGD000034	ACTH Syndrome, Ectopic	Neoplasms
C0001430	BXGD000054	Adenoma	Neoplasms
C0001627	BXGD000068	Congenital adrenal hyperplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0001973	BXGD000095	Alcoholic Intoxication, Chronic	Chemically-Induced Disorders; Mental Disorders
C0003125	BXGD000179	Anorexia Nervosa	Mental Disorders
C0003130	BXGD000183	Anoxia	Pathological Conditions, Signs and Symptoms
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003469	BXGD000195	Anxiety Disorders	Mental Disorders
C0003864	BXGD000231	Arthritis	Musculoskeletal Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096	BXGD000252	Asthma	Respiratory Tract Diseases; Immune System Diseases
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004775	BXGD000290	Bartter Disease	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007114	BXGD000431	Malignant neoplasm of skin	Neoplasms; Skin and Connective Tissue Diseases
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007134	BXGD000443	Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0008497	BXGD000549	Choriocarcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009324	BXGD000597	Ulcerative Colitis	Digestive System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009404	BXGD000606	Colorectal Neoplasms	Digestive System Diseases; Neoplasms
C0010346	BXGD000664	Crohn Disease	Digestive System Diseases
C0010481	BXGD000673	Cushing Syndrome	Endocrine System Diseases
C0010674	BXGD000683	Cystic Fibrosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881	BXGD000760	Diabetic Nephropathy	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013170	BXGD000802	Drug habituation	Chemically-Induced Disorders; Mental Disorders
C0013336	BXGD000815	Dwarfism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013537	BXGD000853	Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0015544	BXGD001003	Failure to Thrive	Pathological Conditions, Signs and Symptoms
C0015672	BXGD001011	Fatigue	Pathological Conditions, Signs and Symptoms
C0015930	BXGD001025	Fetal Distress	Pathological Conditions, Signs and Symptoms
C0015934	BXGD001026	Fetal Growth Retardation	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0018790	BXGD001221	Cardiac Arrest	Cardiovascular Diseases
C0018965	BXGD001258	Hematuria	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020175	BXGD001362	Hunger	Behavior and Behavior Mechanisms
C0020428	BXGD001377	Hyperaldosteronism	Endocrine System Diseases
C0020488	BXGD001402	Hypernatremia	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020621	BXGD001449	Hypokalemia	Nutritional and Metabolic Diseases
C0020625	BXGD001451	Hyponatremia	Nutritional and Metabolic Diseases
C0021053	BXGD001476	Immune System Diseases	Immune System Diseases
C0021390	BXGD001503	Inflammatory Bowel Diseases	Digestive System Diseases
C0022104	BXGD001529	Irritable Bowel Syndrome	Digestive System Diseases
C0022658	BXGD001570	Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661	BXGD001572	Kidney Failure, Chronic	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023343	BXGD001635	Leprosy	Infections
C0023418	BXGD001642	leukemia	Neoplasms
C0023452	BXGD001651	Childhood Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024301	BXGD001759	Lymphoma, Follicular	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0025202	BXGD001832	melanoma	Neoplasms
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0026691	BXGD001917	Mucocutaneous Lymph Node Syndrome	Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027051	BXGD001963	Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027709	BXGD002026	Nephrocalcinosis	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027726	BXGD002030	Nephrotic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453	BXGD002154	Osteopenia	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463	BXGD002160	Osteosarcoma	Neoplasms
C0029866	BXGD002174	Other ureteric obstruction	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0032019	BXGD002321	Pituitary Neoplasms	Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032584	BXGD002363	polyps	Pathological Conditions, Signs and Symptoms
C0032914	BXGD002379	Pre-Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0032962	BXGD002382	Pregnancy Complications	Female Urogenital Diseases and Pregnancy Complications
C0035222	BXGD002513	Respiratory Distress Syndrome, Adult	Respiratory Tract Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0038443	BXGD002757	Stress, Psychological	Behavior and Behavior Mechanisms
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0040137	BXGD002846	Thyroid Nodule	Neoplasms; Endocrine System Diseases
C0042870	BXGD003008	Vitamin D Deficiency	Nutritional and Metabolic Diseases
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085570	BXGD003186	Hypokalemic alkalosis	Nutritional and Metabolic Diseases
C0085580	BXGD003191	Essential Hypertension	Cardiovascular Diseases
C0085593	BXGD003196	Chills	Pathological Conditions, Signs and Symptoms
C0085602	BXGD003199	Polydipsia	Pathological Conditions, Signs and Symptoms
C0086132	BXGD003264	Depressive Symptoms	Behavior and Behavior Mechanisms
C0149516	BXGD003324	Chronic sinusitis	Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0149721	BXGD003349	Left Ventricular Hypertrophy	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152132	BXGD003547	Hypertensive Retinopathy	Eye Diseases; Cardiovascular Diseases
C0205734	BXGD004115	Diabetes, Autoimmune	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0206667	BXGD004228	Adrenal Cortical Adenoma	Neoplasms; Endocrine System Diseases
C0220983	BXGD004350	Metabolic alkalosis	Nutritional and Metabolic Diseases
C0221043	BXGD004377	Liddle Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0221406	BXGD004459	Pituitary-dependent Cushing's disease	Nervous System Diseases; Endocrine System Diseases
C0233794	BXGD004618	Memory impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235991	BXGD004802	Small for gestational age (disorder)	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0238052	BXGD004866	Xanthomatosis, Cerebrotendinous	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0239946	BXGD005010	Fibrosis, Liver	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0241880	BXGD005120	Endometriosis of pelvis	Female Urogenital Diseases and Pregnancy Complications
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0271650	BXGD006227	Impaired glucose tolerance	Nutritional and Metabolic Diseases
C0302511	BXGD006849	Small for gestational age fetus	Pathological Conditions, Signs and Symptoms
C0342302	BXGD007458	Brittle diabetes	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0342443	BXGD007481	Adrenal Cushing's syndrome	Endocrine System Diseases
C0342488	BXGD007488	Mineralocorticoid Excess Syndrome, Apparent	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0349588	BXGD007933	Short stature
C0376185	BXGD007982	Hypoaldosteronism, Hyporeninemic	Endocrine System Diseases
C0410480	BXGD008429	Avascular Necrosis of Femur Head	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0456070	BXGD008863	Growth delay
C0476237	BXGD008983	Metabolic symptoms
C0520463	BXGD009085	Chronic active hepatitis	Digestive System Diseases
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0525045	BXGD009255	Mood Disorders	Mental Disorders
C0553723	BXGD009416	Squamous cell carcinoma of skin	Neoplasms; Skin and Connective Tissue Diseases
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0598428	BXGD009665	genetic hypertension	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0598766	BXGD009669	Leukemogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0677776	BXGD009728	Hereditary Breast and Ovarian Cancer Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Endocrine System Diseases
C0677936	BXGD009737	Refractory cancer	Neoplasms
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0699893	BXGD009871	Skin carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0740898	BXGD010014	Hypokalemic metabolic alkalosis
C0747845	BXGD010184	early pregnancy
C0852036	BXGD010934	Pregnancy associated hypertension	Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0857899	BXGD011166	Decreased circulating aldosterone level	Immune System Diseases; Endocrine System Diseases
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0920646	BXGD011471	Ischemia of kidney	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1112472	BXGD011671	Aeromonas hydrophila infection
C1269955	BXGD012005	Tumor Cell Invasion
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1328504	BXGD012469	Hormone refractory prostate cancer	Neoplasms; Male Urogenital Diseases
C1332977	BXGD012569	Childhood Leukemia	Neoplasms
C1332986	BXGD012574	Childhood Osteosarcoma	Neoplasms
C1395512	BXGD012989	Placental dysfunction
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1561643	BXGD013363	Chronic Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565489	BXGD013401	Renal Insufficiency	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1739135	BXGD013733	Progression of prostate cancer
C1845206	BXGD014727	Decreased circulating renin level
C1857276	BXGD015688	Trichohepatoenteric Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1861403	BXGD016045	Variable expressivity
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2316810	BXGD017030	Chronic kidney disease stage 5	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2919142	BXGD017867	Short Stature, CTCAE
C3536572	BXGD019065	End stage renal disease due to hypertension	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C3837958	BXGD019756	Diabetes Mellitus, Ketosis-Prone	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C3887949	BXGD019932	Apparent mineralocorticoid excess	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4017360	BXGD020442	APPARENT MINERALOCORTICOID EXCESS, MILD
C4022825	BXGD021007	Abnormal urine sodium concentration
C4023214	BXGD021146	Abnormality of circulating cortisol level
C4524092	BXGD023092	Chronic rhinosinusitis with nasal polyps
C4543692	BXGD023273	Anxiety in pregnancy
C4554117	BXGD023561	Diabetes Mellitus, Sudden-Onset	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000578	Herniarin		176.17
BXGC0000681	Umbelliferone		162.14
BXGC0003426	(-)-Kaur-16-en-19-oic acid		302.46
BXGC0003631	Phytosterol		414.72
BXGC0008219	11-Keto-beta-boswellic acid		470.68
BXGC0011627	Glycyrrhetic acid		470.69
BXGC0013582	Curcumin		368.13
BXGC0017345	Maslinic Acid Methyl Ester		486.37
BXGC0020601	3-O-cis-p-coumaroyltormentic acid		634.39
BXGC0026595	Glycyrrhizin		822.4
BXGC0029810	1,5-Bis(4-Hydroxy-3-Methoxyphenyl)-1,4-Pentadien-3-One		326.12
BXGC0033947	3-O-trans-p-coumaroyltormentic acid		634.39
BXGC0034601	Tomentic Acid		488.35
BXGC0034610	Tormentic Acid Methyl Ester		502.37
BXGC0035197	Acetyl-11-Keto-Beta-Boswellic Acid		512.35
BXGC0039114	n.a		470.34
BXGC0041271	Corosolic Acid Methyl Ester		486.37
BXGC0043670	Uvaol		442.38
BXGC0043689	Methyl Ursolate		470.38
BXGC0047088	Ursolic Acid		456.36
BXGC0049758	Corosolic Acid		472.36
BXGC0050317	Acetoxolone		512.35
BXGC0050329	3-Epicorosolic Acid Methyl Ester		486.37

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}