Showing entry for Alpha-1A adrenergic receptor



                       
General Target Information
BXGT IdBXGT012217
Protein NameAlpha-1A adrenergic receptor
Uniport IdP97718
GeneAdra1a
Gene Id11549
Domain7tm_1
Pfam PF00001  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007202 activation of phospholipase C activity
Biological Process GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
Biological Process GO:0007512 adult heart development
Biological Process GO:0007568 aging
Biological Process GO:0060402 calcium ion transport into cytosol
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0061049 cell growth involved in cardiac muscle cell development
Biological Process GO:0060073 micturition
Biological Process GO:0010507 negative regulation of autophagy
Biological Process GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
Biological Process GO:0035024 negative regulation of Rho protein signal transduction
Biological Process GO:0150099 neuron-glial cell signaling
Biological Process GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
Biological Process GO:0035265 organ growth
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0097195 pilomotor reflex
Biological Process GO:0045760 positive regulation of action potential
Biological Process GO:0060452 positive regulation of cardiac muscle contraction
Biological Process GO:0010613 positive regulation of cardiac muscle hypertrophy
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0010460 positive regulation of heart rate
Biological Process GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
Biological Process GO:0090037 positive regulation of protein kinase C signaling
Biological Process GO:0045987 positive regulation of smooth muscle contraction
Biological Process GO:0032230 positive regulation of synaptic transmission, GABAergic
Biological Process GO:0003084 positive regulation of systemic arterial blood pressure
Biological Process GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
Biological Process GO:0045907 positive regulation of vasoconstriction
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
Biological Process GO:0042493 response to drug
Biological Process GO:0009725 response to hormone
molecular function GO:0004937 alpha1-adrenergic receptor activity
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0046982 protein heterodimerization activity
cellular component GO:0005901 caveola
cellular component GO:0005737 cytoplasm
cellular component GO:0098691 dopaminergic synapse
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0016020 membrane
cellular component GO:0031965 nuclear membrane
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0030315 T-tubule
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003196 Aripiprazole 448.39
BXGC0027118 Tamsulosin 408.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein