Showing entry for Clathrin heavy chain 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012539
Protein NameClathrin heavy chain 1
Uniport IdQ00610
GeneCLTC
Gene Id1213
DomainClathrin; Clathrin-link; Clathrin_H_link; Clathrin_propel
Pfam PF00637   PF09268   PF01394  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.6 Nervous system hsa04721 Synaptic vesicle cycle
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
6. Human Diseases 6.4 Neurodegenerative diseases hsa05016 Huntington disease
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05100 Bacterial invasion of epithelial cells
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0150093 amyloid-beta clearance by transcytosis
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0006914 autophagy
Biological Process GO:0051301 cell division
Biological Process GO:0048268 clathrin coat assembly
Biological Process GO:0072583 clathrin-dependent endocytosis
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0034383 low-density lipoprotein particle clearance
Biological Process GO:0032802 low-density lipoprotein particle receptor catabolic process
Biological Process GO:0061024 membrane organization
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:1900126 negative regulation of hyaluronan biosynthetic process
Biological Process GO:1903077 negative regulation of protein localization to plasma membrane
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0031623 receptor internalization
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0060236 regulation of mitotic spindle organization
Biological Process GO:0042147 retrograde transport, endosome to Golgi
Biological Process GO:0033572 transferrin transport
Biological Process GO:0060071 Wnt signaling pathway, planar cell polarity pathway
molecular function GO:0032051 clathrin light chain binding
molecular function GO:0097718 disordered domain specific binding
molecular function GO:0003725 double-stranded RNA binding
molecular function GO:0050750 low-density lipoprotein particle receptor binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0003723 RNA binding
molecular function GO:0005198 structural molecule activity
molecular function GO:1990381 ubiquitin-specific protease binding
cellular component GO:0030118 clathrin coat
cellular component GO:0045334 clathrin-coated endocytic vesicle
cellular component GO:0030669 clathrin-coated endocytic vesicle membrane
cellular component GO:0030136 clathrin-coated vesicle
cellular component GO:0030132 clathrin coat of coated pit
cellular component GO:0030130 clathrin coat of trans-Golgi network vesicle
cellular component GO:0071439 clathrin complex
cellular component GO:0005829 cytosol
cellular component GO:0036020 endolysosome membrane
cellular component GO:0005768 endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:1903561 extracellular vesicle
cellular component GO:0005925 focal adhesion
cellular component GO:0005764 lysosome
cellular component GO:0042470 melanosome
cellular component GO:0016020 membrane
cellular component GO:0072686 mitotic spindle
cellular component GO:1990498 mitotic spindle microtubule
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0005819 spindle
cellular component GO:0032588 trans-Golgi network membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-166520 Signaling by NTRKs
R-HSA-166520 Signaling by NTRKs
R-HSA-168255 Influenza Infection
R-HSA-168256 Immune System
R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-190828 Gap junction trafficking
R-HSA-190873 Gap junction degradation
R-HSA-195721 Signaling by WNT
R-HSA-196025 Formation of annular gap junctions
R-HSA-199991 Membrane Trafficking
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-373760 L1CAM interactions
R-HSA-373760 L1CAM interactions
R-HSA-382551 Transport of small molecules
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-4086400 PCP/CE pathway
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-437239 Recycling pathway of L1
R-HSA-437239 Recycling pathway of L1
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8964038 LDL clearance
R-HSA-8964043 Plasma lipoprotein clearance
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011226 BXGD000704 Hepatitis D Infection Digestive System Diseases; Infections
C0012236 BXGD000772 DiGeorge Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013390 BXGD000828 Dysmenorrhea Pathological Conditions, Signs and Symptoms
C0013394 BXGD000830 Dyspareunia (female) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019069 BXGD001277 Hemophilia A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030794 BXGD002254 Pelvic Pain Pathological Conditions, Signs and Symptoms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220704 BXGD004327 Shprintzen syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0221166 BXGD004397 Paraparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239676 BXGD004989 High forehead
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240379 BXGD005033 Open mouth (finding)
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0278619 BXGD006550 Extramedullary Plasmacytoma Neoplasms; Immune System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0334121 BXGD006996 Inflammatory Myofibroblastic Tumor Pathological Conditions, Signs and Symptoms
C0342208 BXGD007445 Multinodular goiter Neoplasms; Endocrine System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423110 BXGD008471 Downward slant of palpebral fissure
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0432072 BXGD008718 Dysmorphic features
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684275 BXGD009792 Hemophilia, NOS Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0746102 BXGD010136 Chronic lung disease Respiratory Tract Diseases
C0850758 BXGD010909 Pelvic pain female Pathological Conditions, Signs and Symptoms
C0949056 BXGD011567 Infection caused by Coxiella Infections
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1301363 BXGD012292 Blastic plasmacytoid dendritic cell neoplasm Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333177 BXGD012605 Lymphoproliferative Disorder of the Skin Skin and Connective Tissue Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1842581 BXGD014525 Abnormal corpus callosum morphology Pathological Conditions, Signs and Symptoms
C1847514 BXGD014868 Postnatal microcephaly
C1855285 BXGD015483 Protruding ear
C1857704 BXGD015741 Abnormal myelination
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861403 BXGD016045 Variable expressivity
C1861453 BXGD016049 Pseudohyperkalemia Cardiff Nutritional and Metabolic Diseases
C1863512 BXGD016181 HYPERCHOLESTEROLEMIA, AUTOSOMAL RECESSIVE Nutritional and Metabolic Diseases
C1865014 BXGD016282 Long philtrum
C1865017 BXGD016283 Thin upper lip vermilion
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4023687 BXGD021243 EEG with multifocal slow activity
C4025846 BXGD021826 Abnormality of vision
C4049392 BXGD021929 Chronic hepatitis C genotype 1
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4518356 BXGD023020 MiT family translocation renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4693389 BXGD023597 MENTAL RETARDATION, AUTOSOMAL DOMINANT 56
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein