protein

Showing entry for 3-hydroxy-3-methylglutaryl-coenzyme A reductase

General Target Information
BXGT Id	BXGT012578
Protein Name	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Uniport Id	Q01237
Gene	Hmgcr
Gene Id	15357
Domain	HMG-CoA_red; Sterol-sensing
Pfam	PF00368 PF12349
Organism	Mus musculus (Mouse)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0007568	aging
Biological Process	GO:0038183	bile acid signaling pathway
Biological Process	GO:0006695	cholesterol biosynthetic process
Biological Process	GO:0042632	cholesterol homeostasis
Biological Process	GO:0015936	coenzyme A metabolic process
Biological Process	GO:0008299	isoprenoid biosynthetic process
Biological Process	GO:0045445	myoblast differentiation
Biological Process	GO:1900222	negative regulation of amyloid-beta clearance
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0097756	negative regulation of blood vessel diameter
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process	GO:0043407	negative regulation of MAP kinase activity
Biological Process	GO:0042177	negative regulation of protein catabolic process
Biological Process	GO:0050709	negative regulation of protein secretion
Biological Process	GO:0010664	negative regulation of striated muscle cell apoptotic process
Biological Process	GO:0061045	negative regulation of wound healing
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0048643	positive regulation of skeletal muscle tissue development
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade
Biological Process	GO:0070723	response to cholesterol
Biological Process	GO:0045471	response to ethanol
Biological Process	GO:0007584	response to nutrient
Biological Process	GO:0016126	sterol biosynthetic process
Biological Process	GO:0070328	triglyceride homeostasis
Biological Process	GO:0006743	ubiquinone metabolic process
Biological Process	GO:0008542	visual learning
molecular function	GO:0120225	coenzyme A binding
molecular function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
molecular function	GO:0042282	hydroxymethylglutaryl-CoA reductase activity
molecular function	GO:0042802	identical protein binding
molecular function	GO:0070402	NADPH binding
molecular function	GO:0051721	protein phosphatase 2A binding
cellular component	GO:0005783	endoplasmic reticulum
cellular component	GO:0005789	endoplasmic reticulum membrane
cellular component	GO:0016021	integral component of membrane
cellular component	GO:0043231	intracellular membrane-bounded organelle
cellular component	GO:0005778	peroxisomal membrane

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0039684	Berberine Chloride		336.12
BXGC0040850	artemisinine		282.15
BXGC0047126	Artemether		298.18

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}