Showing entry for Alpha-2A adrenergic receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012584
Protein NameAlpha-2A adrenergic receptor
Uniport IdQ01338
GeneAdra2a
Gene Id11551
Domain7tm_1
Pfam PF00001  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0032148 activation of protein kinase B activity
Biological Process GO:0002526 acute inflammatory response
Biological Process GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
Biological Process GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0071875 adrenergic receptor signaling pathway
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0006260 DNA replication
Biological Process GO:0042596 fear response
Biological Process GO:0007565 female pregnancy
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0045955 negative regulation of calcium ion-dependent exocytosis
Biological Process GO:0046676 negative regulation of insulin secretion
Biological Process GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0050995 negative regulation of lipid catabolic process
Biological Process GO:0070473 negative regulation of uterine smooth muscle contraction
Biological Process GO:0071882 phospholipase C-activating adrenergic receptor signaling pathway
Biological Process GO:0030168 platelet activation
Biological Process GO:0097755 positive regulation of blood vessel diameter
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0001819 positive regulation of cytokine production
Biological Process GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0043406 positive regulation of MAP kinase activity
Biological Process GO:0051044 positive regulation of membrane protein ectodomain proteolysis
Biological Process GO:0090303 positive regulation of wound healing
Biological Process GO:0035624 receptor transactivation
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
Biological Process GO:0019229 regulation of vasoconstriction
Biological Process GO:0050955 thermoception
molecular function GO:0004935 adrenergic receptor activity
molecular function GO:0004938 alpha2-adrenergic receptor activity
molecular function GO:0031696 alpha-2C adrenergic receptor binding
molecular function GO:0051379 epinephrine binding
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0032795 heterotrimeric G-protein binding
molecular function GO:0042802 identical protein binding
molecular function GO:0051380 norepinephrine binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0031996 thioesterase binding
cellular component GO:0043679 axon terminus
cellular component GO:0005737 cytoplasm
cellular component GO:0098691 dopaminergic synapse
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099061 integral component of postsynaptic density membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0099059 integral component of presynaptic active zone membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000538 (R)-Norepinephrine 169.18
BXGC0000572 Naphthalene 128.17
BXGC0017443 Phenylephrine 167.09
BXGC0021893 Norepinephrine 169.07
BXGC0046755 Yohimbine 354.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein