Showing entry for Defensin-5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012594
Protein NameDefensin-5
Uniport IdQ01523
GeneDEFA5
Gene Id1670
DomainDefensin_1; Defensin_propep
Pfam PF00323   PF00879  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:0019730 antimicrobial humoral response
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0050832 defense response to fungus
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0045087 innate immune response
Biological Process GO:0002227 innate immune response in mucosa
Biological Process GO:0051873 killing by host of symbiont cells
Biological Process GO:0031640 killing of cells of other organism
Biological Process GO:0051673 membrane disruption in other organism
Biological Process GO:1905710 positive regulation of membrane permeability
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005796 Golgi lumen
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0030496 midbody
cellular component GO:0034774 secretory granule lumen
cellular component GO:0030133 transport vesicle
Reactome
Pathway Id Pathway Name
R-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6803157 Antimicrobial peptides
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0004623 BXGD000282 Bacterial Infections Infections
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0013371 BXGD000823 Shigella Infections Digestive System Diseases; Infections
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0031269 BXGD002297 Peutz-Jeghers Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Skin and Connective Tissue Diseases
C0032584 BXGD002363 polyps Pathological Conditions, Signs and Symptoms
C0036916 BXGD002643 Sexually Transmitted Diseases Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0085166 BXGD003136 Bacterial Vaginosis Female Urogenital Diseases and Pregnancy Complications; Infections
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0206677 BXGD004234 Adenomatous Polyps Neoplasms
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0333983 BXGD006975 Hyperplastic Polyp Pathological Conditions, Signs and Symptoms
C0334037 BXGD006980 Intestinal metaplasia
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0856825 BXGD011118 Acute GVH disease Immune System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C2062441 BXGD016897 Influenza A
C2363741 BXGD017100 HIV-1 infection
C3714514 BXGD019409 Infection Infections
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0004266 2-Propanol 60.1
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein