Showing entry for Exosome component 10


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012614
Protein NameExosome component 10
Uniport IdQ01780
GeneEXOSC10
Gene Id5394
DomainDNA_pol_A_exo1; HRDC; PMC2NT
Pfam PF01612   PF00570   PF08066  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa03018 RNA degradation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071034 CUT catabolic process
Biological Process GO:0009048 dosage compensation by inactivation of X chromosome
Biological Process GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0071044 histone mRNA catabolic process
Biological Process GO:0000460 maturation of 5.8S rRNA
Biological Process GO:0032211 negative regulation of telomere maintenance via telomerase
Biological Process GO:0071028 nuclear mRNA surveillance
Biological Process GO:0071040 nuclear polyadenylation-dependent antisense transcript catabolic process
Biological Process GO:0071039 nuclear polyadenylation-dependent CUT catabolic process
Biological Process GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
Biological Process GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process
Biological Process GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process
Biological Process GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process
Biological Process GO:0071048 nuclear retention of unspliced pre-mRNA at the site of transcription
Biological Process GO:0000956 nuclear-transcribed mRNA catabolic process
Biological Process GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process GO:0071051 polyadenylation-dependent snoRNA 3'-end processing
Biological Process GO:1904872 regulation of telomerase RNA localization to Cajal body
Biological Process GO:0006364 rRNA processing
molecular function GO:0000175 3'-5'-exoribonuclease activity
molecular function GO:0004532 exoribonuclease activity
molecular function GO:0000166 nucleotide binding
molecular function GO:0003723 RNA binding
molecular function GO:0003727 single-stranded RNA binding
molecular function GO:0070034 telomerase RNA binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0000178 exosome (RNase complex)
cellular component GO:0016020 membrane
cellular component GO:0000176 nuclear exosome (RNase complex)
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0035327 transcriptionally active chromatin
Reactome
Pathway Id Pathway Name
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72312 rRNA processing
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0040420 BXGD002861 Tonometry
C0085655 BXGD003226 Polymyositis Musculoskeletal Diseases; Nervous System Diseases
C0410000 BXGD008406 Overlap syndrome Skin and Connective Tissue Diseases; Immune System Diseases
C0751356 BXGD010406 Idiopathic Inflammatory Myopathies Musculoskeletal Diseases; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein