Showing entry for Guanylate cyclase soluble subunit alpha-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012634
Protein NameGuanylate cyclase soluble subunit alpha-1
Uniport IdQ02108
GeneGUCY1A1
Gene Id2982
DomainGuanylate_cyc; HNOB; HNOBA
Pfam PF00211   PF07700   PF07701  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008015 blood circulation
Biological Process GO:0006182 cGMP biosynthetic process
Biological Process GO:0007263 nitric oxide mediated signal transduction
Biological Process GO:0010750 positive regulation of nitric oxide mediated signal transduction
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0060087 relaxation of vascular associated smooth muscle
molecular function GO:0005525 GTP binding
molecular function GO:0004383 guanylate cyclase activity
molecular function GO:0020037 heme binding
molecular function GO:0038023 signaling receptor activity
cellular component GO:0008074 guanylate cyclase complex, soluble
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-392154 Nitric oxide stimulates guanylate cyclase
R-HSA-397014 Muscle contraction
R-HSA-418346 Platelet homeostasis
R-HSA-445355 Smooth Muscle Contraction
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005823 BXGD000339 Blood Pressure
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0014848 BXGD000955 Esophageal Achalasia Digestive System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0034735 BXGD002487 Raynaud Phenomenon Cardiovascular Diseases
C0036095 BXGD002576 Salivary Gland Neoplasms Neoplasms; Stomatognathic Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0087086 BXGD003320 Thrombus Cardiovascular Diseases
C0220636 BXGD004304 Malignant neoplasm of salivary gland Neoplasms; Stomatognathic Diseases
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0263401 BXGD005298 Cutis marmorata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases; Cardiovascular Diseases; Wounds and Injuries
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0340100 BXGD007304 High altitude pulmonary edema Respiratory Tract Diseases
C0340552 BXGD007347 High altitude pulmonary hypertension Respiratory Tract Diseases
C0428883 BXGD008639 Diastolic blood pressure
C0428886 BXGD008640 Mean blood pressure
C0541767 BXGD009260 Platelet aggregation abnormal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0871470 BXGD011316 Systolic Pressure
C1305849 BXGD012347 Diastolic blood pressure measurement
C1306620 BXGD012371 Systolic blood pressure measurement
C1321756 BXGD012440 Achalasia
C1832662 BXGD013867 MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO
C1861403 BXGD016045 Variable expressivity
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C3810403 BXGD019655 MOYAMOYA DISEASE 6 WITH OR WITHOUT ACHALASIA
C4016144 BXGD020281 MOYAMOYA 6 WITH ACHALASIA
C4023169 BXGD021133 Moyamoya phenomenon
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein