Showing entry for Growth hormone-releasing hormone receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012660
Protein NameGrowth hormone-releasing hormone receptor
Uniport IdQ02643
GeneGHRHR
Gene Id2692
Domain7tm_2; HRM
Pfam PF00002   PF02793  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007190 activation of adenylate cyclase activity
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0019933 cAMP-mediated signaling
Biological Process GO:0048469 cell maturation
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0008340 determination of adult lifespan
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0042445 hormone metabolic process
Biological Process GO:0007595 lactation
Biological Process GO:0048609 multicellular organismal reproductive process
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
Biological Process GO:0060124 positive regulation of growth hormone secretion
Biological Process GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
Biological Process GO:0040018 positive regulation of multicellular organism growth
Biological Process GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway
Biological Process GO:0051246 regulation of protein metabolic process
Biological Process GO:0043627 response to estrogen
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0032868 response to insulin
Biological Process GO:0060133 somatotropin secreting cell development
Biological Process GO:0030104 water homeostasis
molecular function GO:0008528 G protein-coupled peptide receptor activity
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0019838 growth factor binding
molecular function GO:0016520 growth hormone-releasing hormone receptor activity
molecular function GO:0017046 peptide hormone binding
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0016021 integral component of membrane
cellular component GO:0005637 nuclear inner membrane
cellular component GO:0016363 nuclear matrix
cellular component GO:0005640 nuclear outer membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0042383 sarcolemma
cellular component GO:0030141 secretory granule
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-372790 Signaling by GPCR
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-500792 GPCR ligand binding
R-HSA-5663205 Infectious disease
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001206 BXGD000033 Acromegaly Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013338 BXGD000816 Pituitary dwarfism Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0013403 BXGD000832 Dysplastic Nevus Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0020635 BXGD001455 Hypopituitarism Nervous System Diseases; Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027341 BXGD001982 Nail-Patella Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0032002 BXGD002320 Pituitary Diseases Nervous System Diseases; Endocrine System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033375 BXGD002405 Prolactinoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033999 BXGD002448 Pterygium Eye Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0154564 BXGD003720 Specific disorders of sleep of non-organic origin Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0206693 BXGD004244 Medullary carcinoma Neoplasms
C0242343 BXGD005153 Panhypopituitarism Nervous System Diseases; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0271561 BXGD006213 Somatotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0271568 BXGD006214 Laron Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0271801 BXGD006262 Central hypothyroidism Endocrine System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0342388 BXGD007473 Adrenocorticotropic hormone (ACTH) deficiency (disorder) Endocrine System Diseases
C0342573 BXGD007508 PITUITARY DWARFISM I Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0343641 BXGD007636 Human papilloma virus infection Infections
C0346302 BXGD007807 Growth Hormone-Secreting Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0346402 BXGD007823 Malignant neoplasm of adrenal cortex Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0521158 BXGD009130 Recurrent tumor
C0576093 BXGD009525 Knee joint valgus deformity Musculoskeletal Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740852 BXGD010011 Upper airway obstruction
C0744483 BXGD010100 growth hormone treatment
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0855173 BXGD011078 Placental Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0878787 BXGD011392 Growth failure
C0948740 BXGD011550 Hypoplasia of the pituitary gland
C1261473 BXGD011855 Sarcoma Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1739135 BXGD013733 Progression of prostate cancer
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1837475 BXGD014236 Insulin-Like Growth Factor I Deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1849157 BXGD015018 Resistance to Insulin-Like Growth Factor I Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1867441 BXGD016455 Pterygium Of Conjunctiva And Cornea Eye Diseases
C2748571 BXGD017599 Isolated Growth Hormone Deficiency, Type IB Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C3164407 BXGD018528 Oligoasthenozoospermia
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3665349 BXGD019280 Secondary hypothyroidism Endocrine System Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3714796 BXGD019434 Isolated somatotropin deficiency
C4020969 BXGD020517 Inflammatory abnormality of the eye
C4520843 BXGD023043 Pterygium of eye Eye Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722273 BXGD023795 ISOLATED GROWTH HORMONE DEFICIENCY, TYPE IV
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein