Showing entry for Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012769
Protein NameProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Uniport IdQ04631
GeneFnta
Gene Id25318
DomainPPTA
Pfam PF01239  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
Biological Process GO:0045213 neurotransmitter receptor metabolic process
Biological Process GO:0045787 positive regulation of cell cycle
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0090045 positive regulation of deacetylase activity
Biological Process GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Biological Process GO:0090044 positive regulation of tubulin deacetylation
Biological Process GO:0018343 protein farnesylation
Biological Process GO:0018344 protein geranylgeranylation
Biological Process GO:0034097 response to cytokine
Biological Process GO:0010035 response to inorganic substance
Biological Process GO:0014070 response to organic cyclic compound
molecular function GO:0030548 acetylcholine receptor regulator activity
molecular function GO:0043014 alpha-tubulin binding
molecular function GO:0004662 CAAX-protein geranylgeranyltransferase activity
molecular function GO:0008017 microtubule binding
molecular function GO:0004660 protein farnesyltransferase activity
molecular function GO:0004661 protein geranylgeranyltransferase activity
molecular function GO:0004663 Rab geranylgeranyltransferase activity
molecular function GO:0030971 receptor tyrosine kinase binding
cellular component GO:0005953 CAAX-protein geranylgeranyltransferase complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005875 microtubule associated complex
cellular component GO:0005965 protein farnesyltransferase complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0003705 Chloride 35.45
BXGC0004277 Acetic acid 60.05
BXGC0045257 Lonafarnib 636.05
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein