Showing entry for Activin receptor type-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012783
Protein NameActivin receptor type-1
Uniport IdQ04771
GeneACVR1
Gene Id90
DomainActivin_recp; Pkinase_Tyr; TGF_beta_GS
Pfam PF01064   PF07714   PF08515  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032924 activin receptor signaling pathway
Biological Process GO:0002526 acute inflammatory response
Biological Process GO:0001525 angiogenesis
Biological Process GO:0003289 atrial septum primum morphogenesis
Biological Process GO:0003181 atrioventricular valve morphogenesis
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0061312 BMP signaling pathway involved in heart development
Biological Process GO:0001569 branching involved in blood vessel morphogenesis
Biological Process GO:0060923 cardiac muscle cell fate commitment
Biological Process GO:0071773 cellular response to BMP stimulus
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0007368 determination of left/right symmetry
Biological Process GO:0009953 dorsal/ventral pattern formation
Biological Process GO:0003143 embryonic heart tube morphogenesis
Biological Process GO:0061445 endocardial cushion cell fate commitment
Biological Process GO:0003274 endocardial cushion fusion
Biological Process GO:0003203 endocardial cushion morphogenesis
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0001702 gastrulation with mouth forming second
Biological Process GO:0007281 germ cell development
Biological Process GO:0007507 heart development
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0001707 mesoderm formation
Biological Process GO:0003183 mitral valve morphogenesis
Biological Process GO:0032926 negative regulation of activin receptor signaling pathway
Biological Process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Biological Process GO:0009968 negative regulation of signal transduction
Biological Process GO:0001755 neural crest cell migration
Biological Process GO:0060389 pathway-restricted SMAD protein phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0060037 pharyngeal system development
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:2000017 positive regulation of determination of dorsal identity
Biological Process GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0030278 regulation of ossification
Biological Process GO:0051145 smooth muscle cell differentiation
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
Biological Process GO:0060412 ventricular septum morphogenesis
molecular function GO:0048185 activin binding
molecular function GO:0016361 activin receptor activity, type I
molecular function GO:0005524 ATP binding
molecular function GO:0045296 cadherin binding
molecular function GO:0046872 metal ion binding
molecular function GO:0017046 peptide hormone binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:1990782 protein tyrosine kinase binding
molecular function GO:0046332 SMAD binding
molecular function GO:0050431 transforming growth factor beta binding
molecular function GO:0005025 transforming growth factor beta receptor activity, type I
molecular function GO:0004675 transmembrane receptor protein serine/threonine kinase activity
cellular component GO:0048179 activin receptor complex
cellular component GO:0045177 apical part of cell
cellular component GO:0070724 BMP receptor complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009782 BXGD000631 Connective Tissue Diseases Skin and Connective Tissue Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011430 BXGD000723 Dentin Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014116 BXGD000892 Endocardial Cushion Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0016037 BXGD001035 Fibrodysplasia Ossificans Progressiva Musculoskeletal Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018536 BXGD001201 Hallux Valgus Musculoskeletal Diseases
C0018552 BXGD001202 Hamartoma Neoplasms
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025988 BXGD001883 Microglossia Stomatognathic Diseases
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027122 BXGD001974 Myositis Ossificans Musculoskeletal Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028326 BXGD002075 Noonan Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0028756 BXGD002083 Obesity, Morbid Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036631 BXGD002626 Seminoma Neoplasms
C0085576 BXGD003188 Iron-Refractory Iron Deficiency Anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0151811 BXGD003478 Subcutaneous nodule Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0158458 BXGD003886 Acquired hallux valgus Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205768 BXGD004119 Subependymal Giant Cell Astrocytoma Neoplasms
C0206648 BXGD004213 Myofibromatosis Neoplasms
C0206681 BXGD004236 Adenocarcinoma, Clear Cell Neoplasms
C0220603 BXGD004293 Childhood Brain Neoplasm Neoplasms; Nervous System Diseases
C0220620 BXGD004299 Gastrointestinal Carcinoid Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0233705 BXGD004604 Cancerophobia Mental Disorders
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242488 BXGD005170 Acute Lung Injury Respiratory Tract Diseases
C0259783 BXGD005221 mixed gliomas Neoplasms
C0265656 BXGD005560 Congenital hallux valgus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0280783 BXGD006759 Juvenile Pilocytic Astrocytoma Neoplasms
C0280785 BXGD006760 Diffuse Astrocytoma Neoplasms
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0332790 BXGD006899 Osseous ankylosis Musculoskeletal Diseases
C0334041 BXGD006982 Osteoma cutis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0334579 BXGD007120 Anaplastic astrocytoma Neoplasms
C0334580 BXGD007121 Protoplasmic astrocytoma Neoplasms
C0334581 BXGD007122 Gemistocytic astrocytoma Neoplasms
C0334582 BXGD007123 Fibrillary Astrocytoma Neoplasms
C0334583 BXGD007124 Pilocytic Astrocytoma Neoplasms
C0338070 BXGD007165 Childhood Cerebral Astrocytoma Neoplasms
C0344735 BXGD007702 Partial atrioventricular canal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432284 BXGD008765 Infantile myofibromatosis Neoplasms
C0547065 BXGD009355 Mixed oligoastrocytoma Neoplasms
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677865 BXGD009732 Brain Stem Glioma Neoplasms; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0750935 BXGD010257 Cerebral Astrocytoma Neoplasms
C0750936 BXGD010258 Intracranial Astrocytoma Neoplasms
C0858617 BXGD011183 Posterior subcapsular cataract Eye Diseases
C0879615 BXGD011394 Stromal Neoplasm Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0949690 BXGD011584 Spondylarthritis Musculoskeletal Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1266129 BXGD011970 Atypical Lipoma Neoplasms
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1302790 BXGD012313 Congenital malformation syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332079 BXGD012486 Anaplastic Large Cell Lymphoma, ALK-Positive Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332951 BXGD012562 Childhood Brain Stem Neoplasm Neoplasms; Nervous System Diseases
C1337014 BXGD012877 Grade I Chondrosarcoma Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1389016 BXGD012962 ATRIOVENTRICULAR CANAL DEFECT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1389018 BXGD012963 Atrioventricular Septal Defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1704230 BXGD013533 Grade I Astrocytoma Neoplasms
C1705254 BXGD013568 Neonatal Deformity Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1834129 BXGD013957 Abnormal vertebral morphology
C1844813 BXGD014679 Widely spaced teeth
C1849016 BXGD014995 Broad femoral neck
C1849039 BXGD014999 Metaphyseal widening
C1849311 BXGD015034 Short 1st metacarpal
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1851129 BXGD015200 Progressive cervical vertebral spine fusion
C1851130 BXGD015201 Small cervical vertebral bodies
C1857108 BXGD015677 Limitation of joint mobility
C1858025 BXGD015760 Spinal rigidity
C1865992 BXGD016359 Short hallux
C2827362 BXGD017794 Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
C2930619 BXGD017890 Sex Differentiation Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2986658 BXGD018234 Diffuse Intrinsic Pontine Glioma
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021626 BXGD020703 Lethal skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4023094 BXGD021102 Ectopic ossification in ligament tissue Pathological Conditions, Signs and Symptoms
C4023095 BXGD021103 Ectopic ossification in tendon tissue Pathological Conditions, Signs and Symptoms
C4023096 BXGD021104 Ectopic ossification in muscle tissue Pathological Conditions, Signs and Symptoms
C4024079 BXGD021285 Aplasia/Hypoplasia of the phalanges of the hallux
C4024082 BXGD021286 Abnormality of the first metatarsal bone
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4049796 BXGD021951 Abnormality of cardiovascular system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4722099 BXGD023789 High grade glioma Neoplasms
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000076 p-Coumaroyl tartaric acid glucosidic ester 150.09
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000696 Tartaric acid 150.09
BXGC0002586 Calcium 40.08
BXGC0002591 Potassium 39.1
BXGC0013109 4-[2-(3,5-Dihydroxyphenyl)Ethenyl]Benzene-1,2-Diol 244.07
BXGC0030612 tetraethylene glycol 194.12
BXGC0042315 1,4-dioxane 88.05
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein