Showing entry for Son of sevenless homolog 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012946
Protein NameSon of sevenless homolog 1
Uniport IdQ07889
GeneSOS1
Gene Id6654
DomainHistone; PH; RasGEF; RasGEF_N; RhoGEF
Pfam PF00125   PF00169   PF00617   PF00618   PF00621  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01522 Endocrine resistance
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04012 ErbB signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
3. Environmental Information Processing 3.2 Signal transduction hsa04630 Jak-STAT signaling pathway
5. Organismal Systems 5.1 Immune system hsa04650 Natural killer cell mediated cytotoxicity
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04662 B cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04664 Fc epsilon RI signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04917 Prolactin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04926 Relaxin signaling pathway
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05210 Colorectal cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05211 Renal cell carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05213 Endometrial cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05214 Glioma
6. Human Diseases 6.2 Cancers: Specific types hsa05215 Prostate cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05220 Chronic myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05221 Acute myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05223 Non-small cell lung cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05224 Breast cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05225 Hepatocellular carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05226 Gastric cancer
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007411 axon guidance
Biological Process GO:0001782 B cell homeostasis
Biological Process GO:0048514 blood vessel morphogenesis
Biological Process GO:0003209 cardiac atrium morphogenesis
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0038128 ERBB2 signaling pathway
Biological Process GO:0061029 eyelid development in camera-type eye
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0001942 hair follicle development
Biological Process GO:0061384 heart trabecula morphogenesis
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0000165 MAPK cascade
Biological Process GO:1904693 midbrain morphogenesis
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0048011 neurotrophin TRK receptor signaling pathway
Biological Process GO:0003344 pericardium morphogenesis
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0051057 positive regulation of small GTPase mediated signal transduction
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:2000973 regulation of pro-B cell differentiation
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0033081 regulation of T cell differentiation in thymus
Biological Process GO:0042129 regulation of T cell proliferation
Biological Process GO:0060021 roof of mouth development
Biological Process GO:0007165 signal transduction
Biological Process GO:0007296 vitellogenesis
molecular function GO:0003677 DNA binding
molecular function GO:0005096 GTPase activator activity
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0005088 Ras guanyl-nucleotide exchange factor activity
molecular function GO:0005089 Rho guanyl-nucleotide exchange factor activity
molecular function GO:0017124 SH3 domain binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-112399 IRS-mediated signalling
R-HSA-112399 IRS-mediated signalling
R-HSA-112412 SOS-mediated signalling
R-HSA-112412 SOS-mediated signalling
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-1227986 Signaling by ERBB2
R-HSA-1227986 Signaling by ERBB2
R-HSA-1227990 Signaling by ERBB2 in Cancer
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1236394 Signaling by ERBB4
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1433559 Regulation of KIT signaling
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-1643713 Signaling by EGFR in Cancer
R-HSA-166520 Signaling by NTRKs
R-HSA-166520 Signaling by NTRKs
R-HSA-167044 Signalling to RAS
R-HSA-167044 Signalling to RAS
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-177929 Signaling by EGFR
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-186763 Downstream signal transduction
R-HSA-186797 Signaling by PDGF
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187687 Signalling to ERKs
R-HSA-187687 Signalling to ERKs
R-HSA-190236 Signaling by FGFR
R-HSA-193648 NRAGE signals death through JNK
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194840 Rho GTPase cycle
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
R-HSA-210993 Tie2 Signaling
R-HSA-2172127 DAP12 interactions
R-HSA-2179392 EGFR Transactivation by Gastrin
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2424491 DAP12 signaling
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-354192 Integrin signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372790 Signaling by GPCR
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-376176 Signaling by ROBO receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-428540 Activation of RAC1
R-HSA-449147 Signaling by Interleukins
R-HSA-451927 Interleukin-2 family signaling
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5637812 Signaling by EGFRvIII in Cancer
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654708 Downstream signaling of activated FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654743 Signaling by FGFR4
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5655332 Signaling by FGFR3 in disease
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6806834 Signaling by MET
R-HSA-73887 Death Receptor Signalling
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74752 Signaling by Insulin receptor
R-HSA-74752 Signaling by Insulin receptor
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-8851805 MET activates RAS signaling
R-HSA-8853334 Signaling by FGFR3 fusions in cancer
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-8853659 RET signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-9006335 Signaling by Erythropoietin
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9034015 Signaling by NTRK3 (TRKC)
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2
R-HSA-9664565 Signaling by ERBB2 KD Mutants
R-HSA-9665348 Signaling by ERBB2 ECD mutants
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants
R-HSA-9669938 Signaling by KIT in disease
R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
R-HSA-9671555 Signaling by PDGFR in disease
R-HSA-9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003838 BXGD000224 Arterial Occlusive Diseases Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009207 BXGD000593 Cockayne Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010051 BXGD000646 Coronary Aneurysm Cardiovascular Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0016049 BXGD001039 Fibromatosis, Gingival Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0016522 BXGD001067 Foramen Ovale, Patent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019322 BXGD001317 Umbilical hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0020224 BXGD001366 Polyhydramnios Female Urogenital Diseases and Pregnancy Complications
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024236 BXGD001752 Lymphedema Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024636 BXGD001793 Malocclusion Stomatognathic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025269 BXGD001847 Multiple Endocrine Neoplasia Type 2b Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027059 BXGD001965 Myocarditis Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0027960 BXGD002062 Nevus Neoplasms
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0028326 BXGD002075 Noonan Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0030354 BXGD002214 Papilloma Neoplasms
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0032897 BXGD002378 Prader-Willi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034089 BXGD002462 Pulmonary Valve Stenosis Cardiovascular Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0041408 BXGD002923 Turner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0041409 BXGD002924 Turner Syndrome, Male Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0079504 BXGD003080 Hermanski-Pudlak Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085084 BXGD003121 Motor Neuron Disease Nervous System Diseases
C0085167 BXGD003137 Granular cell tumor Neoplasms
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153574 BXGD003667 Malignant Uterine Corpus Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0158465 BXGD003887 Acquired cubitus valgus
C0158731 BXGD003902 Congenital pectus carinatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0158761 BXGD003905 Radioulnar Synostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0175691 BXGD003999 Dubowitz syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0175693 BXGD004001 Russell-Silver syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0175701 BXGD004007 Aarskog syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0175704 BXGD004010 LEOPARD Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0178829 BXGD004036 reproductive system disorder Pathological Conditions, Signs and Symptoms
C0206620 BXGD004187 Lymphangioma, Cystic Neoplasms
C0206656 BXGD004219 Embryonal Rhabdomyosarcoma Neoplasms
C0206728 BXGD004273 Plexiform Neurofibroma Neoplasms; Nervous System Diseases
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0221217 BXGD004408 Neck webbing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0221263 BXGD004427 Cafe-au-Lait Spots Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221356 BXGD004448 Brachycephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0232466 BXGD004543 Feeding difficulties
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238397 BXGD004923 Pulmonary artery stenosis Cardiovascular Diseases
C0239676 BXGD004989 High forehead
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0243050 BXGD005212 Cardiovascular Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0263383 BXGD005296 Keratosis pilaris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0263428 BXGD005304 Burnett Schwartz Berberian syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0265202 BXGD005461 Seckel syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0265205 BXGD005462 Robinow Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Endocrine System Diseases
C0265339 BXGD005523 Borjeson-Forssman-Lehmann syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0270972 BXGD006147 Cornelia De Lange Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0271561 BXGD006213 Somatotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0271623 BXGD006222 Hypogonadotropic hypogonadism Endocrine System Diseases
C0277959 BXGD006487 Coarse hair
C0278704 BXGD006567 Malignant Childhood Neoplasm Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0279612 BXGD006650 Childhood Embryonal Rhabdomyosarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339528 BXGD007261 X-linked retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0342513 BXGD007494 Idiopathic hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0347915 BXGD007862 Congenital malformation syndromes associated with short stature Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0349639 BXGD007943 Juvenile Myelomonocytic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376480 BXGD007998 Gingival Overgrowth Stomatognathic Diseases
C0393570 BXGD008093 Corticobasal degeneration Nervous System Diseases
C0399440 BXGD008244 Hereditary gingival fibromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0423112 BXGD008472 Short palpebral fissure
C0424492 BXGD008531 Coarse features
C0431399 BXGD008684 Familial aplasia of the vermis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Male Urogenital Diseases
C0431663 BXGD008700 Bilateral Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0432072 BXGD008718 Dysmorphic features
C0432333 BXGD008778 Abnormal dermatoglyphic pattern Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0521525 BXGD009139 Short neck
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541764 BXGD009259 Delayed bone age
C0557874 BXGD009444 Global developmental delay
C0558165 BXGD009449 Curly hair (finding)
C0578626 BXGD009551 blue iris (physical finding)
C0587248 BXGD009617 Costello syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0741916 BXGD010044 Cardiac defects
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0855740 BXGD011086 Abnormal platelet function
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0878552 BXGD011369 Coronary artery ectasia
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1136249 BXGD011715 Mental Retardation, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1275081 BXGD012056 Cardio-facio-cutaneous syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1328931 BXGD012477 Multiple lentigines
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1519666 BXGD013240 Tumor-Associated Vasculature
C1527404 BXGD013289 Female Pseudo-Turner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1827524 BXGD013773 Wide spaced nipples
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1834120 BXGD013955 NOONAN-LIKE/MULTIPLE GIANT CELL LESION SYNDROME (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C1835884 BXGD014061 Triangular face
C1836542 BXGD014129 Depressed nasal bridge
C1836933 BXGD014181 Low-set nipples
C1836940 BXGD014182 Thickened nuchal skin fold
C1837732 BXGD014261 Thickened helices
C1839739 BXGD014400 Thick lower lip vermilion
C1839758 BXGD014402 Narrow forehead
C1839797 BXGD014409 Deep philtrum
C1840077 BXGD014434 Anteverted nostril
C1842366 BXGD014512 Low anterior hairline
C1843181 BXGD014564 Noonan syndrome-like disorder with loose anagen hair Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1845667 BXGD014756 RETINITIS PIGMENTOSA 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1846821 BXGD014841 Abnormality of coagulation
C1849367 BXGD015046 Nasal bridge wide
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1853120 BXGD015303 Noonan Syndrome 4 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C1853195 BXGD015313 Prostate Cancer, Hereditary, 7 Neoplasms; Male Urogenital Diseases
C1853242 BXGD015322 Midface retrusion
C1853638 BXGD015349 Broad neck
C1854114 BXGD015383 Short nose
C1855728 BXGD015536 Low posterior hairline
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1857539 BXGD015716 Deep palmar crease
C1857953 BXGD015759 Deep plantar creases
C1858991 BXGD015841 Childhood Ataxia with Central Nervous System Hypomyelinization Nervous System Diseases
C1859807 BXGD015932 AMYOTROPHIC LATERAL SCLEROSIS 2, JUVENILE (disorder) Nutritional and Metabolic Diseases; Nervous System Diseases
C1860245 BXGD015972 Cranial asymmetry
C1860493 BXGD015987 Abnormality of the sternum
C1860991 BXGD016009 NOONAN SYNDROME 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C1864796 BXGD016251 Pectus excavatum of inferior sternum
C1865017 BXGD016283 Thin upper lip vermilion
C1956257 BXGD016623 Pulmonary Stenosis Cardiovascular Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2674608 BXGD017250 Feeding difficulties in infancy
C2919142 BXGD017867 Short Stature, CTCAE
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2960129 BXGD018198 Vanishing white matter disease Nervous System Diseases
C3164374 BXGD018527 Abnormality of pulmonary valve
C3164445 BXGD018529 Abnormality of aortic valve
C3276036 BXGD018682 High anterior hairline
C3501846 BXGD019029 Noonan-Like Syndrome With Loose Anagen Hair Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C3553764 BXGD019187 Joint hyperflexibility
C4020962 BXGD020512 Enlarged thorax
C4022662 BXGD020948 Abnormality of lateral ventricle
C4023385 BXGD021170 Aplasia of the semicircular canal
C4023397 BXGD021175 Abnormal hair quantity
C4023676 BXGD021237 Increased nuchal translucency Pathological Conditions, Signs and Symptoms
C4023909 BXGD021272 Aplasia/Hypoplasia of the abdominal wall musculature
C4024165 BXGD021293 Prominent ear helix
C4025749 BXGD021773 Abnormality of the spleen
C4025871 BXGD021839 Abnormality of the face
C4049446 BXGD021933 Neointimal hyperplasia
C4049650 BXGD021946 Familial Glucocorticoid Deficiency Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Endocrine System Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4282407 BXGD022423 Sparse and thin eyebrow
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4551558 BXGD023348 Fibromatosis, Gingival, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C4551602 BXGD023369 Noonan Syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4743661 BXGD023935 Leukocyte Adhesion Deficiency Type 3
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0003705 Chloride 35.45
BXGC0006368 Formic acid 46.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein