Showing entry for CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013218
Protein NameCMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Uniport IdQ11203
GeneST3GAL3
Gene Id6487
DomainGlyco_transf_29
Pfam PF00777  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00514 Other types of O-glycan biosynthesis
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00515 Mannose type O-glycan biosynthesis
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0018146 keratan sulfate biosynthetic process
Biological Process GO:0016266 O-glycan processing
Biological Process GO:0006486 protein glycosylation
molecular function GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity
molecular function GO:0008373 sialyltransferase activity
cellular component GO:0005576 extracellular region
cellular component GO:0032580 Golgi cisterna membrane
cellular component GO:0000139 Golgi membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-1638074 Keratan sulfate/keratin metabolism
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism
R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15
R-HSA-3781865 Diseases of glycosylation
R-HSA-392499 Metabolism of proteins
R-HSA-4085001 Sialic acid metabolism
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
R-HSA-5173105 O-linked glycosylation
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-5668914 Diseases of metabolism
R-HSA-597592 Post-translational protein modification
R-HSA-71387 Metabolism of carbohydrates
R-HSA-9033658 Blood group systems biosynthesis
R-HSA-9037629 Lewis blood group biosynthesis
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-9678108 SARS-CoV-1 Infection
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679506 SARS-CoV Infections
R-HSA-9683673 Maturation of protein 3a
R-HSA-9683701 Translation of structural proteins
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694548 Maturation of spike protein
R-HSA-9694635 Translation of structural proteins
R-HSA-9694635 Translation of structural proteins
R-HSA-9694719 Maturation of protein 3a
R-HSA-977068 Termination of O-glycan biosynthesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0033999 BXGD002448 Pterygium Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0151546 BXGD003437 Oral Cavity Carcinoma Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0262630 BXGD005262 Reduced concentration span Behavior and Behavior Mechanisms
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0282577 BXGD006816 Congenital Disorders of Glycosylation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0422895 BXGD008464 Primitive reflex
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0431371 BXGD008676 Absence of septum pellucidum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0431380 BXGD008680 Cortical Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0521158 BXGD009130 Recurrent tumor
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1445953 BXGD013080 Poor eye contact Mental Disorders
C1527366 BXGD013280 Salaam Seizures Nervous System Diseases
C1527390 BXGD013285 Neoplasms, Intracranial Neoplasms; Nervous System Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1611184 BXGD013455 Calcification of coronary artery Nutritional and Metabolic Diseases; Cardiovascular Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1838319 BXGD014309 Primitive reflexes (palmomental, snout, glabellar) Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1842364 BXGD014511 Central hypotonia
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859470 BXGD015896 Large basal ganglia
C1867441 BXGD016455 Pterygium Of Conjunctiva And Cornea Eye Diseases
C1970200 BXGD016820 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 12 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C3161330 BXGD018511 Profound intellectual disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3554316 BXGD019207 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 15
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021219 BXGD020582 Multifocal epileptiform discharges
C4023528 BXGD021211 Abnormality of skin morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4520843 BXGD023043 Pterygium of eye Eye Diseases
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4552810 BXGD023525 Irritability, CTCAE
C4553743 BXGD023548 Spasticity, CTCAE
C4721779 BXGD023769 Ovarian cancer stage IV
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002976 ent-Epigallocatechin 3-gallate 458.37
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein