Showing entry for Receptor-type tyrosine-protein phosphatase eta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013279
Protein NameReceptor-type tyrosine-protein phosphatase eta
Uniport IdQ12913
GenePTPRJ
Gene Id5795
Domainfn3; PTP_tm; Y_phosphatase
Pfam PF00041   PF18861   PF00102  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04520 Adherens junction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0035584 calcium-mediated signaling using intracellular calcium source
Biological Process GO:0060242 contact inhibition
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0043407 negative regulation of MAP kinase activity
Biological Process GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
Biological Process GO:0051898 negative regulation of protein kinase B signaling
Biological Process GO:0050860 negative regulation of T cell receptor signaling pathway
Biological Process GO:0043116 negative regulation of vascular permeability
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0035335 peptidyl-tyrosine dephosphorylation
Biological Process GO:0048008 platelet-derived growth factor receptor signaling pathway
Biological Process GO:0050918 positive chemotaxis
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
Biological Process GO:0051894 positive regulation of focal adhesion assembly
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0050852 T cell receptor signaling pathway
molecular function GO:0008013 beta-catenin binding
molecular function GO:0045296 cadherin binding
molecular function GO:0070097 delta-catenin binding
molecular function GO:0045295 gamma-catenin binding
molecular function GO:0051019 mitogen-activated protein kinase binding
molecular function GO:0016791 phosphatase activity
molecular function GO:0005161 platelet-derived growth factor receptor binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0004725 protein tyrosine phosphatase activity
cellular component GO:0005911 cell-cell junction
cellular component GO:0009986 cell surface
cellular component GO:0070062 extracellular exosome
cellular component GO:0001772 immunological synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0032587 ruffle membrane
cellular component GO:0035579 specific granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-202403 TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-6798695 Neutrophil degranulation
R-HSA-6806834 Signaling by MET
R-HSA-6807004 Negative regulation of MET activity
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009405 BXGD000607 Hereditary Nonpolyposis Colorectal Neoplasms Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023051 BXGD001602 Laryngeal Diseases Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027832 BXGD002048 Neurofibromatosis 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040411 BXGD002859 Tongue Neoplasms Neoplasms; Stomatognathic Diseases
C0040420 BXGD002861 Tonometry
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0152136 BXGD003548 Low Tension Glaucoma Eye Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0202236 BXGD004086 Triglycerides measurement
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242647 BXGD005184 Mucosa-Associated Lymphoid Tissue Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0271270 BXGD006178 Oculovestibuloauditory syndrome Eye Diseases; Nervous System Diseases; Cardiovascular Diseases
C0272285 BXGD006336 Heparin-induced thrombocytopenia Hemic and Lymphatic Diseases
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0424574 BXGD008534 Duration of sleep
C0489786 BXGD009018 Height
C0543874 BXGD009299 Apraxia, oculomotor, Cogan type Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0595921 BXGD009626 Intraocular pressure disorder Eye Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1112155 BXGD011647 Hereditary non-polyposis colorectal cancer syndrome
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333990 BXGD012670 Hereditary Nonpolyposis Colorectal Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C1333991 BXGD012671 Hereditary Non-Polyposis Colon Cancer Type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C1367654 BXGD012886 Marginal Zone B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1368683 BXGD012900 Epithelioma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2936783 BXGD018136 Colorectal cancer, hereditary nonpolyposis, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C4049446 BXGD021933 Neointimal hyperplasia
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein