Showing entry for Glutamate receptor ionotropic, kainate 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013304
Protein NameGlutamate receptor ionotropic, kainate 3
Uniport IdQ13003
GeneGRIK3
Gene Id2899
DomainANF_receptor; Lig_chan; Lig_chan-Glu_bd
Pfam PF01094   PF00060   PF10613  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007215 glutamate receptor signaling pathway
Biological Process GO:0007216 G protein-coupled glutamate receptor signaling pathway
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0051967 negative regulation of synaptic transmission, glutamatergic
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0099505 regulation of presynaptic membrane potential
Biological Process GO:0035249 synaptic transmission, glutamatergic
molecular function GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
molecular function GO:0008066 glutamate receptor activity
molecular function GO:0004970 ionotropic glutamate receptor activity
molecular function GO:0015277 kainate selective glutamate receptor activity
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0038023 signaling receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0030424 axon
cellular component GO:0030425 dendrite
cellular component GO:0032839 dendrite cytoplasm
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0032983 kainate selective glutamate receptor complex
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0042734 presynaptic membrane
cellular component GO:0043195 terminal bouton
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-451306 Ionotropic activity of kainate receptors
R-HSA-451308 Activation of Ca-permeable Kainate Receptor
R-HSA-451326 Activation of kainate receptors upon glutamate binding
R-HSA-500657 Presynaptic function of Kainate receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001957 BXGD000093 Alcohol Withdrawal Delirium Nervous System Diseases; Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013473 BXGD000845 Eating Disorders Mental Disorders
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028768 BXGD002084 Obsessive-Compulsive Disorder Mental Disorders
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0041296 BXGD002903 Tuberculosis Infections
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0154409 BXGD003717 Recurrent major depressive episodes Mental Disorders
C0221271 BXGD004431 Elastosis perforans serpiginosa Skin and Connective Tissue Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0443306 BXGD008817 Spastic Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0853193 BXGD010968 Bipolar I disorder Mental Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1737329 BXGD013728 Dysmorphism Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1868684 BXGD016527 EAR, PATELLA, SHORT STATURE SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0036476 D-Glutamate 147.05
BXGC0049516 Kainic Acid 213.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein