Showing entry for Corticotropin-releasing factor receptor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013340
Protein NameCorticotropin-releasing factor receptor 2
Uniport IdQ13324
GeneCRHR2
Gene Id1395
Domain7tm_2; HRM
Pfam PF00002   PF02793  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0060291 long-term synaptic potentiation
molecular function GO:0015056 corticotrophin-releasing factor receptor activity
molecular function GO:0043404 corticotropin-releasing hormone receptor activity
molecular function GO:0008528 G protein-coupled peptide receptor activity
molecular function GO:0017046 peptide hormone binding
cellular component GO:0043679 axon terminus
cellular component GO:0030425 dendrite
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-2980736 Peptide hormone metabolism
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-392499 Metabolism of proteins
R-HSA-418555 G alpha (s) signalling events
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
R-HSA-5663205 Infectious disease
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0008495 BXGD000548 Chorioamnionitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0009171 BXGD000587 Cocaine Abuse Chemically-Induced Disorders; Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009374 BXGD000601 Colonic Diseases, Functional Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013473 BXGD000845 Eating Disorders Mental Disorders
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019337 BXGD001319 Heroin Dependence Chemically-Induced Disorders; Mental Disorders
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022116 BXGD001531 Ischemia Pathological Conditions, Signs and Symptoms
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0026846 BXGD001939 Muscular Atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038443 BXGD002757 Stress, Psychological Behavior and Behavior Mechanisms
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178417 BXGD004025 Anhedonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0232849 BXGD004565 Bladder pain Pathological Conditions, Signs and Symptoms
C0233477 BXGD004581 Dysphoric mood Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0236736 BXGD004825 Cocaine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0238013 BXGD004855 Invasive aspergillosis Infections
C0243050 BXGD005212 Cardiovascular Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0264716 BXGD005417 Chronic heart failure Cardiovascular Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0338908 BXGD007218 Mixed anxiety and depressive disorder Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349489 BXGD007911 Fetal Hypoxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376280 BXGD007983 Anxiety States, Neurotic Mental Disorders
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0520459 BXGD009084 Necrotizing Enterocolitis Digestive System Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0578159 BXGD009543 Antibiotic-associated diarrhea Pathological Conditions, Signs and Symptoms
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1279420 BXGD012122 Anxiety neurosis (finding) Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1849718 BXGD015080 POPLITEAL PTERYGIUM SYNDROME, LETHAL TYPE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Stomatognathic Diseases
C1867773 BXGD016471 CEREBRAL AMYLOID ANGIOPATHY, ITM2B-RELATED, 1
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
C4296683 BXGD022516 Emotional neglect
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001200 3-Hydroxy-4-isopentenyl-5-methoxybibenzyl-2-carboxylic acid 340.41
BXGC0005513 Hexadecanoic acid 256.42
BXGC0016973 Guvacine Hydrochloride 127.06
BXGC0022806 1-(5-Thiophen-2-Ylthiophen-2-Yl)Ethanone 208
BXGC0023490 saikosaponin 780.47
BXGC0036632 Austrobailignan 6 328.17
BXGC0038316 Cholesterol 386.35
BXGC0044812 Sid14737105 261.14
BXGC0052566 Sid22414536 180.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein