protein

Showing entry for Acid ceramidase

General Target Information
BXGT Id	BXGT013367
Protein Name	Acid ceramidase
Uniport Id	Q13510
Gene	ASAH1
Gene Id	427
Domain	CBAH; NA-beta
Pfam	PF02275 PF15508
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.3 Lipid metabolism	hsa00600	Sphingolipid metabolism
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways
3. Environmental Information Processing	3.2 Signal transduction	hsa04071	Sphingolipid signaling pathway
4. Cellular Processes	4.1 Transport and catabolism	hsa04142	Lysosome

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0046513	ceramide biosynthetic process
Biological Process	GO:0046514	ceramide catabolic process
Biological Process	GO:0006687	glycosphingolipid metabolic process
Biological Process	GO:0030216	keratinocyte differentiation
Biological Process	GO:1903507	negative regulation of nucleic acid-templated transcription
Biological Process	GO:0043312	neutrophil degranulation
Biological Process	GO:0062098	regulation of programmed necrotic cell death
Biological Process	GO:0050810	regulation of steroid biosynthetic process
Biological Process	GO:0046512	sphingosine biosynthetic process
molecular function	GO:0102121	ceramidase activity
molecular function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
molecular function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
molecular function	GO:0017040	N-acylsphingosine amidohydrolase activity
molecular function	GO:0016922	nuclear receptor binding
molecular function	GO:0003714	transcription corepressor activity
cellular component	GO:0070062	extracellular exosome
cellular component	GO:0005576	extracellular region
cellular component	GO:0005615	extracellular space
cellular component	GO:1904813	ficolin-1-rich granule lumen
cellular component	GO:0043202	lysosomal lumen
cellular component	GO:0005764	lysosome
cellular component	GO:0005634	nucleus
cellular component	GO:1904724	tertiary granule lumen

Reactome

Pathway Id	Pathway Name
R-HSA-1430728	Metabolism
R-HSA-1660662	Glycosphingolipid metabolism
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-428157	Sphingolipid metabolism
R-HSA-556833	Metabolism of lipids
R-HSA-6798695	Neutrophil degranulation

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002793	BXGD000130	Anaplasia	Pathological Conditions, Signs and Symptoms; Neoplasms
C0003862	BXGD000230	Arthralgia	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003864	BXGD000231	Arthritis	Musculoskeletal Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004903	BXGD000293	Beckwith-Wiedemann Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0006118	BXGD000372	Brain Neoplasms	Neoplasms; Nervous System Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007113	BXGD000430	Rectal Carcinoma	Digestive System Diseases; Neoplasms
C0007133	BXGD000442	Carcinoma, Papillary	Neoplasms
C0009319	BXGD000596	Colitis	Digestive System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0010038	BXGD000643	Corneal Opacity	Eye Diseases
C0010308	BXGD000661	Congenital Hypothyroidism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0010674	BXGD000683	Cystic Fibrosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0013336	BXGD000815	Dwarfism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014474	BXGD000917	Ependymoma	Neoplasms
C0014544	BXGD000926	Epilepsy	Nervous System Diseases
C0014548	BXGD000928	Epilepsy, Generalized	Nervous System Diseases
C0014550	BXGD000930	Myoclonic Epilepsy	Nervous System Diseases
C0015469	BXGD000996	Facial paralysis	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0015544	BXGD001003	Failure to Thrive	Pathological Conditions, Signs and Symptoms
C0017185	BXGD001104	Gastrointestinal Neoplasms	Digestive System Diseases; Neoplasms
C0017601	BXGD001125	Glaucoma	Eye Diseases
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0018784	BXGD001220	Sensorineural Hearing Loss (disorder)	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019209	BXGD001305	Hepatomegaly	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019348	BXGD001325	Herpes Simplex Infections	Infections; Skin and Connective Tissue Diseases
C0019825	BXGD001349	Hoarseness	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020305	BXGD001374	Hydrops Fetalis	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0020626	BXGD001452	Hypoparathyroidism	Endocrine System Diseases
C0022107	BXGD001530	Irritable Mood	Behavior and Behavior Mechanisms
C0022821	BXGD001590	Kyphosis deformity of spine	Musculoskeletal Diseases
C0023465	BXGD001656	Acute monocytic leukemia	Neoplasms
C0023467	BXGD001658	Leukemia, Myelocytic, Acute	Neoplasms
C0023521	BXGD001679	Globoid cell leukodystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023794	BXGD001700	Lipoidosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0023893	BXGD001716	Liver Cirrhosis, Experimental	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025007	BXGD001821	Measles	Infections
C0025202	BXGD001832	melanoma	Neoplasms
C0025362	BXGD001866	Mental Retardation	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026847	BXGD001940	Spinal Muscular Atrophy	Nervous System Diseases
C0027066	BXGD001966	Myoclonus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0028738	BXGD002081	Nystagmus	Eye Diseases; Nervous System Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030552	BXGD002238	Paresis	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0033578	BXGD002408	Prostatic Neoplasms	Neoplasms; Male Urogenital Diseases
C0033806	BXGD002428	Pseudohypoparathyroidism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0033835	BXGD002432	Pseudopseudohypoparathyroidism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0034069	BXGD002458	Pulmonary Fibrosis	Respiratory Tract Diseases
C0035229	BXGD002516	Respiratory Insufficiency	Respiratory Tract Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036439	BXGD002615	Scoliosis, unspecified	Musculoskeletal Diseases
C0037822	BXGD002706	Speech Disorders	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038002	BXGD002723	Splenomegaly	Pathological Conditions, Signs and Symptoms
C0040136	BXGD002845	Thyroid Neoplasm	Neoplasms; Endocrine System Diseases
C0040822	BXGD002885	Tremor	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041408	BXGD002923	Turner Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0042769	BXGD002999	Virus Diseases	Infections
C0085078	BXGD003118	Lysosomal Storage Diseases	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085084	BXGD003121	Motor Neuron Disease	Nervous System Diseases
C0151611	BXGD003447	Electroencephalogram abnormal	Nervous System Diseases
C0151786	BXGD003475	Muscle Weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152031	BXGD003524	Joint swelling	Pathological Conditions, Signs and Symptoms
C0153676	BXGD003679	Secondary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0158981	BXGD003914	Neonatal diabetes mellitus	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Endocrine System Diseases
C0162298	BXGD003933	Joint stiffness	Musculoskeletal Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0205696	BXGD004107	Anaplastic carcinoma	Neoplasms
C0220603	BXGD004293	Childhood Brain Neoplasm	Neoplasms; Nervous System Diseases
C0221357	BXGD004449	Brachydactyly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221765	BXGD004477	Chronic schizophrenia	Mental Disorders
C0234146	BXGD004626	Absent reflex	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234182	BXGD004631	Gowers sign
C0235480	BXGD004751	Paroxysmal atrial fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0235974	BXGD004796	Pancreatic carcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239548	BXGD004984	Fasciculation, Tongue	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0264303	BXGD005379	Laryngomalacia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0267071	BXGD005730	Oropharyngeal Dysphagia	Digestive System Diseases; Otorhinolaryngologic Diseases
C0268255	BXGD005871	Farber Lipogranulomatosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0271097	BXGD006163	Usher Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0278510	BXGD006526	Childhood Medulloblastoma	Neoplasms
C0278874	BXGD006605	Adult Ependymoma	Neoplasms
C0278878	BXGD006609	Adult Glioblastoma	Neoplasms
C0278883	BXGD006614	Metastatic melanoma	Neoplasms
C0278996	BXGD006621	Malignant Head and Neck Neoplasm	Neoplasms
C0280474	BXGD006748	Childhood Glioblastoma	Neoplasms
C0311394	BXGD006884	Difficulty walking	Pathological Conditions, Signs and Symptoms
C0346647	BXGD007832	Malignant neoplasm of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588	BXGD007933	Short stature
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0376532	BXGD008000	Epilepsy, Rolandic	Nervous System Diseases
C0455988	BXGD008860	Hydrops Fetalis, Non-Immune	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0476403	BXGD008992	Electromyogram abnormal
C0494165	BXGD009022	Secondary malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0497327	BXGD009061	Dementia	Nervous System Diseases; Mental Disorders
C0520947	BXGD009126	Clumsiness - motor delay	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0524851	BXGD009246	Neurodegenerative Disorders	Nervous System Diseases
C0549473	BXGD009384	Thyroid carcinoma	Neoplasms; Endocrine System Diseases
C0557874	BXGD009444	Global developmental delay
C0558356	BXGD009453	Malignant melanoma of eye	Neoplasms; Eye Diseases
C0575081	BXGD009512	Gait abnormality	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0684337	BXGD009796	Ewings sarcoma-primitive neuroectodermal tumor (PNET)	Neoplasms
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0751177	BXGD010338	Cancer of Head	Neoplasms
C0751378	BXGD010420	Neurologic Signs	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751778	BXGD010587	Myoclonic Epilepsies, Progressive	Nervous System Diseases
C0751785	BXGD010594	Unverricht-Lundborg Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752347	BXGD010721	Lewy Body Disease	Nervous System Diseases; Mental Disorders
C0796611	BXGD010835	Newly Diagnosed Childhood Ependymoma	Neoplasms
C0850703	BXGD010905	Frequent falls	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0878675	BXGD011384	Erdheim-Chester Disease	Hemic and Lymphatic Diseases
C0936223	BXGD011477	Metastatic Prostate Carcinoma	Neoplasms; Male Urogenital Diseases
C1134719	BXGD011688	Invasive Ductal Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C1269955	BXGD012005	Tumor Cell Invasion
C1282496	BXGD012147	Metastasis from malignant tumor of prostate
C1301509	BXGD012294	Severe visual impairment	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1527344	BXGD013275	Dysphonia	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1608408	BXGD013434	Malignant transformation
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1704214	BXGD013528	Lipogranuloma	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C1834569	BXGD013980	Jankovic Rivera syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1837108	BXGD014199	Decreased muscle mass
C1843505	BXGD014590	Degeneration of anterior horn cells	Nervous System Diseases
C1851584	BXGD015221	Childhood Ependymoma	Neoplasms
C1854301	BXGD015391	Motor delay	Mental Disorders
C1854838	BXGD015438	Progressive neurologic deterioration	Mental Disorders
C1861403	BXGD016045	Variable expressivity
C1864100	BXGD016212	PSEUDOHYPOPARATHYROIDISM, TYPE IB	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C1963184	BXGD016688	Nystagmus, CTCAE 3.0
C2216370	BXGD016949	Cherry red spot of the macula
C2585653	BXGD017139	Persistent atrial fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2673635	BXGD017217	Combined Saposin Deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2678303	BXGD017402	Hoarse cry	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2700617	BXGD017474	Irritation - emotion	Behavior and Behavior Mechanisms
C2919142	BXGD017867	Short Stature, CTCAE
C2931404	BXGD018018	Albright's hereditary osteodystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C2932715	BXGD018100	Pseudohypoparathyroidism Type 1B	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C2938924	BXGD018167	Oestrogen receptor positive breast cancer
C3149494	BXGD018281	KELOID FORMATION
C3267007	BXGD018609	Hypercalcitoninaemia	Nutritional and Metabolic Diseases
C3468561	BXGD018908	familial atrial fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3494506	BXGD018968	Pseudohypoparathyroidism, Type Ia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C3536893	BXGD019076	Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Neoplasms
C3698239	BXGD019368	Cerebral cortex myoclonus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3714756	BXGD019429	Intellectual Disability	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806306	BXGD019505	Periarticular subcutaneous nodules
C3806467	BXGD019513	Respiratory insufficiency due to muscle weakness	Respiratory Tract Diseases
C3806482	BXGD019514	Recurrent respiratory infections	Infections; Respiratory Tract Diseases
C3887461	BXGD019876	Head and Neck Carcinoma	Neoplasms
C4021759	BXGD020762	Generalized myoclonic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4024613	BXGD021344	Progressive distal muscular atrophy
C4024896	BXGD021461	Motor neuron atrophy
C4025846	BXGD021826	Abnormality of vision
C4551915	BXGD023441	Gait Disturbance, CTCAE
C4552810	BXGD023525	Irritability, CTCAE
C4554036	BXGD023557	Nystagmus, CTCAE 5.0
C4725091	BXGD023828	metastatic intraocular melanoma	Neoplasms; Eye Diseases
C4727838	BXGD023874	Advanced Melanoma

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0018397	beta-1,4-mannan		180.06

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}