Showing entry for Cullin-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013382
Protein NameCullin-3
Uniport IdQ13618
GeneCUL3
Gene Id8452
DomainCullin; Cullin_Nedd8
Pfam PF00888   PF10557  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
3. Environmental Information Processing 3.2 Signal transduction hsa04340 Hedgehog signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031145 anaphase-promoting complex-dependent catabolic process
Biological Process GO:0016477 cell migration
Biological Process GO:0030030 cell projection organization
Biological Process GO:0048208 COPII vesicle coating
Biological Process GO:0040016 embryonic cleavage
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0044346 fibroblast apoptotic process
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0007369 gastrulation
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0097193 intrinsic apoptotic signaling pathway
Biological Process GO:0072576 liver morphogenesis
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0007080 mitotic metaphase plate congression
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0035024 negative regulation of Rho protein signal transduction
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:1901992 positive regulation of mitotic cell cycle phase transition
Biological Process GO:0045842 positive regulation of mitotic metaphase/anaphase transition
Biological Process GO:0031398 positive regulation of protein ubiquitination
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0051865 protein autoubiquitination
Biological Process GO:0031648 protein destabilization
Biological Process GO:0006513 protein monoubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0017145 stem cell division
Biological Process GO:0043149 stress fiber assembly
Biological Process GO:0001831 trophectodermal cellular morphogenesis
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0030332 cyclin binding
molecular function GO:0005112 Notch binding
molecular function GO:0031208 POZ domain binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0005813 centrosome
cellular component GO:0031463 Cul3-RING ubiquitin ligase complex
cellular component GO:0031461 cullin-RING ubiquitin ligase complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0000139 Golgi membrane
cellular component GO:0016020 membrane
cellular component GO:0072686 mitotic spindle
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005827 polar microtubule
cellular component GO:0036126 sperm flagellum
cellular component GO:0000922 spindle pole
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-392499 Metabolism of proteins
R-HSA-4641258 Degradation of DVL
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-597592 Post-translational protein modification
R-HSA-8951664 Neddylation
R-HSA-9607240 FLT3 Signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013537 BXGD000853 Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0013589 BXGD000856 Ectromelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016781 BXGD001079 Fuchs Endothelial Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0020461 BXGD001395 Hyperkalemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0032617 BXGD002367 Polyuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033805 BXGD002427 Pseudohypoaldosteronism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0042834 BXGD003004 Vital capacity
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085679 BXGD003235 Hyperchloremia Nutritional and Metabolic Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0206157 BXGD004165 Myopathies, Nemaline Musculoskeletal Diseases; Nervous System Diseases
C0220666 BXGD004316 ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE IIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0220981 BXGD004348 Metabolic acidosis Nutritional and Metabolic Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242387 BXGD005161 Mandibulofacial Dysostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases
C0279070 BXGD006625 Adult Oligodendroglioma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280475 BXGD006749 Childhood Oligodendroglioma Neoplasms
C0339525 BXGD007258 Autosomal dominant retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346429 BXGD007828 Multiple malignancy Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0432072 BXGD008718 Dysmorphic features
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0598428 BXGD009665 genetic hypertension Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0751688 BXGD010551 Malignant Squamous Cell Neoplasm Neoplasms
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1443924 BXGD013074 Severe diarrhea Pathological Conditions, Signs and Symptoms
C1449842 BXGD013093 Pseudohypoaldosteronism, Type I, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1449844 BXGD013095 Pseudohypoaldosteronism, Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1840389 BXGD014462 Pseudohypoaldosteronism, Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C1969073 BXGD016753 Hyperchloremic metabolic acidosis
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3469605 BXGD018917 PSEUDOHYPOALDOSTERONISM, TYPE IID Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3469606 BXGD018918 PSEUDOHYPOALDOSTERONISM, TYPE IIE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4288936 BXGD022490 Hyperkalemic Mineralocorticoid Resistance
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein