Showing entry for GDP-L-fucose synthase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013386
Protein NameGDP-L-fucose synthase
Uniport IdQ13630
GeneTSTA3
Gene Id7264
DomainEpimerase
Pfam PF01370  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00051 Fructose and mannose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00520 Amino sugar and nucleotide sugar metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0042351 'de novo' GDP-L-fucose biosynthetic process
Biological Process GO:0019673 GDP-mannose metabolic process
Biological Process GO:0007159 leukocyte cell-cell adhesion
Biological Process GO:1904906 positive regulation of endothelial cell-matrix adhesion via fibronectin
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:0001913 T cell mediated cytotoxicity
molecular function GO:0009055 electron transfer activity
molecular function GO:0042356 GDP-4-dehydro-D-rhamnose reductase activity
molecular function GO:0050577 GDP-L-fucose synthase activity
molecular function GO:0047918 GDP-mannose 3,5-epimerase activity
molecular function GO:0042802 identical protein binding
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
R-HSA-392499 Metabolism of proteins
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
R-HSA-597592 Post-translational protein modification
R-HSA-6787639 GDP-fucose biosynthesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1608408 BXGD013434 Malignant transformation
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012750 Guanosine Diphosphate Fucose 589.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein