Showing entry for Activin receptor type-2B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013393
Protein NameActivin receptor type-2B
Uniport IdQ13705
GeneACVR2B
Gene Id93
DomainActivin_recp; Pkinase
Pfam PF01064   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0032924 activin receptor signaling pathway
Biological Process GO:0009952 anterior/posterior pattern specification
Biological Process GO:0060840 artery development
Biological Process GO:0001974 blood vessel remodeling
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0007368 determination of left/right symmetry
Biological Process GO:0048617 embryonic foregut morphogenesis
Biological Process GO:0001702 gastrulation with mouth forming second
Biological Process GO:0007507 heart development
Biological Process GO:0030073 insulin secretion
Biological Process GO:0001822 kidney development
Biological Process GO:0030324 lung development
Biological Process GO:0001946 lymphangiogenesis
Biological Process GO:0060836 lymphatic endothelial cell differentiation
Biological Process GO:0007498 mesoderm development
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0035265 organ growth
Biological Process GO:0031016 pancreas development
Biological Process GO:0032927 positive regulation of activin receptor signaling pathway
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:0009791 post-embryonic development
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0009749 response to glucose
Biological Process GO:0061298 retina vasculature development in camera-type eye
Biological Process GO:0060021 roof of mouth development
Biological Process GO:0007165 signal transduction
Biological Process GO:0048705 skeletal system morphogenesis
Biological Process GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
Biological Process GO:0060841 venous blood vessel development
molecular function GO:0017002 activin-activated receptor activity
molecular function GO:0048185 activin binding
molecular function GO:0005524 ATP binding
molecular function GO:0019838 growth factor binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004712 protein serine/threonine/tyrosine kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0048179 activin receptor complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1181150 Signaling by NODAL
R-HSA-1266738 Developmental Biology
R-HSA-1433617 Regulation of signaling by NODAL
R-HSA-1502540 Signaling by Activin
R-HSA-1502540 Signaling by Activin
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-201451 Signaling by BMP
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9006936 Signaling by TGFB family members
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011813 BXGD000748 Dextrocardia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017654 BXGD001136 Glomerular Filtration Rate
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0022521 BXGD001549 Kartagener Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases; Cardiovascular Diseases
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029434 BXGD002146 Osteogenesis Imperfecta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032584 BXGD002363 polyps Pathological Conditions, Signs and Symptoms
C0035615 BXGD002563 Right aortic arch (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0036631 BXGD002626 Seminoma Neoplasms
C0037221 BXGD002673 Situs Inversus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0039730 BXGD002826 Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0040761 BXGD002883 Transposition of Great Vessels Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0175707 BXGD004011 Asplenia Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0265357 BXGD005530 Polysplenia Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0266632 BXGD005704 Ectopic spleen Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266642 BXGD005705 Situs ambiguus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0344692 BXGD007699 Isomerism of atrial appendages
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0752304 BXGD010711 Hypoxic-Ischemic Encephalopathy Nervous System Diseases; Cardiovascular Diseases
C1153706 BXGD011769 Endometrial adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1167664 BXGD011771 Situs ambiguous
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1320468 BXGD012423 Nephrogenic rest
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1389016 BXGD012962 ATRIOVENTRICULAR CANAL DEFECT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1391732 BXGD012971 Cancer cachexia
C1415817 BXGD013055 HETEROTAXY, VISCERAL, 2, AUTOSOMAL
C1844020 BXGD014625 HETEROTAXY, VISCERAL, 1, X-LINKED Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C1853444 BXGD015336 Heterotaxy, Visceral, 3, Autosomal Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C1866091 BXGD016371 Left-Right Axis Malformations Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C1876171 BXGD016558 Polyasplenia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C1876172 BXGD016559 VAH, AUTOSOMAL RECESSIVE
C1876173 BXGD016560 Heterotaxy, Visceroatrial, Autosomal Recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2910124 BXGD017860 Isomerism of atrial appendages with asplenia or polysplenia
C3151057 BXGD018378 HETEROTAXY, VISCERAL, 4, AUTOSOMAL
C3151867 BXGD018452 CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 1, X-LINKED
C3178805 BXGD018541 Heterotaxy Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C3178806 BXGD018542 Right Atrial Isomerism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C3178807 BXGD018543 Left Atrial Isomerism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C3553676 BXGD019183 HETEROTAXY, VISCERAL, 6, AUTOSOMAL
C3898147 BXGD020064 Neonatal Hypoxic Ischemic Encephalopathy Nervous System Diseases; Cardiovascular Diseases
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4551720 BXGD023400 Primary Ciliary Dyskinesia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0023872 Adenine 135.05
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein